Field and greenhouse studies were conducted in 1995 and 1996 in Kansas to determine the efficacy of 21 herbicide treatments for control of tumble pigweed, Palmer amaranth, redroot pigweed, and two biotypes of common waterhemp in soybean. In field studies, nine of eleven preemergence treatments controlled all four species 90% or more. However, pendimethalin and trifluralin controlled Palmer amaranth, redroot pigweed, and tumble pigweed less than the other preplant incorporated and preemergence treatments. With the exception of flumiclorac and NAF-75, postemergence treatments controlled 75 to 90% of all four species. A biotype of common waterhemp collected in Iowa was not controlled by acetolactate synthase-inhibiting herbicides. Greenhouse results were similar to field experiments. Results suggest at least 90% control of these Amaranthus species is possible with proper herbicide selection.