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In this article we investigate the role of semantic relations in grammatical alternations. The specific alternation we look at is that between the proper name modifier construction, e.g. the Obama government, and the determiner genitive, e.g. Obama's government. Through the use of an experimental study in which participants were asked to rate the naturalness of the two constructions in 20 attested natural language contexts and provide paraphrases of the semantic relations in question, we tested when the two constructions alternate and whether either construction expresses semantic relations that block alternation. Our initial finding is that none of the relations we studied is categorically associated with only one of the constructions, but that certain relations – notably possession and name – are far more preferentially associated with determiner genitives and proper name modifiers respectively. Despite these ‘default’ associations, participants nevertheless identified a range of possible interpretations for many of the examples, meaning that our study simultaneously supports the opposing theoretical views of default relations and semantic underspecification. Further, our study validates the inclusion of semantic relations in genitive alternation studies as a major factor despite the notorious difficulties in their operationalisation. Animacy distinctions, although more straightforward to codify, appear to be of lesser importance. Methodologically, our study shows the value of an experimental approach as a corrective to researcher intuitions about the identification of semantic relations in context.
The observation that personal pronouns typically sound highly unnatural as the object in of-PP dependents of English noun phrases dates back at least to Lyons (1986: 136). In a table comparing the frames [NP’s N], [(Det) N of NP], and [(Det) N of NP’s], he systematically excludes accusative pronouns from the NP position in the second of these. We will employ the terms used by The Cambridge Grammar of the English Language (Huddleston and Pullum et al. 2002) for these three constructions: s-genitive, of-PP, and oblique genitive respectively.
The Omani basement is located spatially distant from the dominantly juvenile Arabian–Nubian Shield (ANS) to its west, and its relationship to the amalgamation of those arc terranes has yet to be properly constrained. The Jebel Ja'alan (NE Oman) basement inlier provides an excellent opportunity to better understand the Neoproterozoic tectonic geography of Oman and its relationship to the ANS. To understand the origin of this basement inlier, we present new radiogenic isotopic data from igneous bodies in Jebel Ja'alan. U–Pb and 40Ar/39Ar geochronological data are used to constrain the timing of magmatism and metamorphism in the jebel. Positive εHf and εNd values indicate a juvenile origin for the igneous lithologies. Phase equilibria modelling is used to constrain the metamorphic conditions recorded by basement. Pressure–temperature (P–T) pseudosections show that basement schists followed a clockwise P–T path, reaching peak metamorphic conditions of c. 650–700°C at 4–7.5 kbar, corresponding to a thermal gradient of c. 90–160°C/kbar. From the calculated thermal gradient, in conjunction with collected trace-element data, we interpret that the Jebel Ja'alan basement formed in an arc environment. Geochronological data indicate that this juvenile arc formed during Tonian time and is older than basement further west in Oman. We argue that the difference in timing is related to westwards arc accretion and migration, which implies that the Omani basement represents its own tectonic domain separate to the ANS and may be the leading edge of the Neoproterozoic accretionary margin of India.
In the United States alone, ∼14,000 children are hospitalised annually with acute heart failure. The science and art of caring for these patients continues to evolve. The International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute was held on February 4 and 5, 2015. The 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute was funded through the Andrews/Daicoff Cardiovascular Program Endowment, a philanthropic collaboration between All Children’s Hospital and the Morsani College of Medicine at the University of South Florida (USF). Sponsored by All Children’s Hospital Andrews/Daicoff Cardiovascular Program, the International Pediatric Heart Failure Summit assembled leaders in clinical and scientific disciplines related to paediatric heart failure and created a multi-disciplinary “think-tank”. The purpose of this manuscript is to summarise the lessons from the 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute, to describe the “state of the art” of the treatment of paediatric cardiac failure, and to discuss future directions for research in the domain of paediatric cardiac failure.
This article discusses the niche role that the oblique genitive of the type the friend of John’s occupies in the context of genitive variation. The article shows that the oblique genitive should be considered an independent construction which competes marginally in two syntactic contexts with the s-genitive (as in John's friend) and the of-genitive (as in the friend of John). The first context is one in which all three constructions function as the predicative complement of the clause (e.g. He is a friend of John's / John's friend / a friend of John). Note that in this context the definiteness effect of the s-genitive is downplayed, so that competition is possible with indefiniteness of the other two constructions. The second context is one where the oblique genitive and the of-genitive are introduced by the determiner the. Contrary to the claim that oblique genitive constructions introduced by the definite article must receive restrictive modification of the head (see e.g. Barker 1998; Lyons 1986), the quantitative data presented in this article reveal that oblique genitives introduced by the determiner the are not confined to pre- or postmodification of the head but can occur, albeit rarely, without any modification as in the example the executor of Sir Ralph’s.
The article further compares the oblique genitive, s-genitive and of-genitive with respect to the following five features: noun-headed vs pronoun dependent; animacy of the dependent; length of the noun-headed dependent; determiner of the head; and the semantic relations that can hold between head (e.g. friend) and dependent (e.g. John). The most intriguing theoretical conclusion is that the semantic relations available to head and dependent in the oblique genitive are a subset of those found in the s-genitive, which, again constitute a subset of those that exist in the of-genitive. This means that variation between all three constructions is not only restricted to the two syntactic contexts outlined above but also to a shared set of semantic relations.
This special issue concerns English genitive variation: the choice between the s-genitive and the of-genitive. It has grown out of the workshop ‘Genitive variation in English’, which was held at the conference of the International Society for the Linguistics of English at the University of Boston in June 2011. While previous research on genitive variation has already unearthed a wealth of factors predicting the variation, the aim of this volume is to add new dimensions to existing parameters.
Recent studies have implicated Ca supplements in vascular risk elevation, and therefore these supplements may also be associated with the occurrence of brain lesions (or hyperintensities) in older adults. These lesions represent damage to brain tissue that is caused by ischaemia. In the present cross-sectional clinical observational study, the association between Ca-containing dietary supplement use and lesion volumes was investigated in a sample of 227 older adults (60 years and above). Food and supplemental Ca intakes were assessed with the Block 1998 FFQ; participants with supplemental Ca intake above zero were categorised as supplement users. Lesion volumes were determined from cranial MRI (1·5 tesla) scans using a semi-automated technique; volumes were log-transformed because they were non-normal. ANCOVA models revealed that supplement users had greater lesion volumes than non-users, even after controlling for food Ca intake, age, sex, race, years of education, energy intake, depression and hypertension (Ca supplement use: β = 0·34, se 0·10, F1,217= 10·98, P= 0·0011). The influence of supplemental Ca use on lesion volume was of a magnitude similar to that of the influence of hypertension, a well-established risk factor for lesions. Among the supplement users, the amount of supplemental Ca was not associated with lesion volume (β = − 0·000035, se 0·00 015, F1,139= 0·06, P= 0·81). The present study demonstrates that the use of Ca-containing dietary supplements, even low-dose supplements, by older adults may be associated with greater lesion volumes. Evaluation of randomised controlled trials is warranted to determine whether this relationship is a causal one.
A vast array of surgical interventions may be performed in the treatment of ocular and periorbital disease. Because of the high technical difficulty, the subspecialist often performs a significant portion of the ophthalmic surgeries. Most procedures in ophthalmology involve microsurgery and are usually limited to the eye and orbit. Thus, typically there is minimal risk to other organs. Ophthalmic surgery offers a high probability of success, with a major positive impact on quality of life. Nevertheless, many patients with eye pathology are elderly, and some have significant systemic illness. Therefore, the risk of elective intervention must be balanced against the expected benefits, and appropriate counseling should be performed prior to surgery. Optimizing the management of medical problems preoperatively can make the surgery safer and minimize patient discomfort.
The large majority of ophthalmic interventions can be performed under local anesthesia with intravenous sedation. In some cases, even topical anesthetics are sufficient. But there are ophthalmic surgeries that require general anesthesia, such as those that involve significant extraocular manipulation, for which the local anesthetic may not be as effective, or those that may be prolonged, as is often the case in many vitreoretinal and orbital procedures. Some periorbital or facial cosmetic interventions often necessitate general anesthesia as well. General anesthesia is also indicated in younger patients and those who may not be cooperative enough to remain motionless during surgery. In addition, general anesthetics are required in trauma cases with significant ocular laceration, where administration of local anesthetics may raise intraorbital pressure, necessitating subsequent extrusion of intraocular contents. Several choices exist in the route of administration of local ophthalmic anesthesia for intraocular surgery. The most widely used approach is injection of 3–7 mL of a mixture of lidocaine 2% and marcaine 0.75% through a retrobulbar approach using a blunted needle (Atkinson needle). This is often performed with a regional seventh nerve block to paralyze eyelid closure. The risks of local ophthalmic anesthesia are remote, but they may be significant. They include local damage through retrobulbar hemorrhage, extraocular muscle damage, and penetration of the globe or optic nerve. Systemic exposure to the injected medication through intravascular or subarachnoid injection of the anesthetic has been known to cause hypertension, seizures, apnea, or even death.