Elinor Ostrom was a leader in using multiple methods to perform institutional analysis. In this paper, we discuss how a multi-method approach she pioneered may be used to study the robustness of social–ecological systems. We synthesize lessons learned from a series of studies on small-scale irrigation systems in which we use case-study analysis, experimental methods in laboratory and field settings, and mathematical models. The accumulated insights show the importance of creating institutional arrangements that fit the human ecology within the biophysical constraints of the system. The examples of work based on multiple methods approaches presented here highlight several lessons. For example, experimental work helps us better understand the details of how the ability to maintain trust relationships, low levels of inequality, and low transaction costs of coordination are critical for success. Likewise, the integration of case-study analysis and modeling helps us better understand how systems that can leverage biophysical characteristics to help address challenges of monitoring, sanctioning, and coordination may be able to increase their chances of success.