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The Magellanic Stream (MS), a tail of diffuse gas formed from tidal and ram pressure interactions between the Small and Large Magellanic Clouds (SMC and LMC) and the Halo of the Milky Way, is primarily composed of neutral atomic hydrogen (HI). The deficiency of dust and the diffuse nature of the present gas make molecular formation rare and difficult, but if present, could lead to regions potentially suitable for star formation, thereby allowing us to probe conditions of star formation similar to those at high redshifts. We search for $\text{HCO}^{+}$, HCN, HNC, and C$_2$H using the highest sensitivity observations of molecular absorption data from the Atacama Large Millimeter Array (ALMA) to trace these regions, comparing with HI archival data from the Galactic Arecibo L-Band Feed Array (GALFA) HI Survey and the Galactic All Sky Survey (GASS) to compare these environments in the MS to the HI column density threshold for molecular formation in the Milky Way. We also compare the line of sight locations with confirmed locations of stars, molecular hydrogen, and OI detections, though at higher sensitivities than the observations presented here.
We find no detections to a 3$\sigma$ significance, despite four sightlines having column densities surpassing the threshold for molecular formation in the diffuse regions of the Milky Way. Here we present our calculations for the upper limits of the column densities of each of these molecular absorption lines, ranging from $3 \times 10^{10}$ to $1 \times 10^{13}$ cm$^{-2}$. The non-detection of $\text{HCO}^{+}$ suggests that at least one of the following is true: (i) $X_{\text{HCO}^{+}{}, \mathrm{MS}}$ is significantly lower than the Milky Way value; (ii) that the widespread diffuse molecular gas observed by Rybarczyk (2022b, ApJ, 928, 79) in the Milky Way’s diffuse interstellar medium (ISM) does not have a direct analogue in the MS; (iii) the HI-to-$\text{H}_{2}$ transition occurs in the MS at a higher surface density in the MS than in the LMC or SMC; or (iv) molecular gas exists in the MS, but only in small, dense clumps.
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
By longstanding tradition the Anglo-Saxon minster of St Frideswide was located on the later site of St Frideswide’s priory (now Oxford cathedral), and John Blair took that identification for granted in his contribution of 1988. In the recent Oxford volume of the Historic Towns Atlas Alan Crossley suggested an alternative location at Oxford Castle. The following contributions set out John Blair’s reaction to Crossley’s ideas, followed by Alan Crossley’s restatement and elaboration of his case and a final thought from John Blair. No resolution is offered by this journal, but readers are given fuller information for future consideration of an issue which has important implications for the early layout of Oxford and its subsequent development.
A REACTION TO ALAN CROSSLEY’s SUGGESTIONS by JOHN BLAIR
The Oxford volume in the Historic Towns Atlas series has long been awaited, and its appearance in 2021 is a matter for celebration. Alongside the rich abundance of primary material that it assembles, it is a vehicle for the summation of past hypotheses and the development of new ones. It crowns the distinguished career of the editor, Alan Crossley, who ran the Oxfordshire Victoria County History for many years, and fought tirelessly for its survival through bleak and adverse circumstances.
The editor has a particular interest in west Oxford, about which he has recently written in other places. Several interesting points are made in the Atlas, not least with reference to St George’s chapel in the Castle, where the recent discovery of two burials dated to c.1000 supports the idea (proposed in 1976 by Janet Cooper) that the Norman chapel replaced a pre-Conquest church. Crossley builds on this argument to take it in an unexpected direction.
It should be said at the outset that an important Anglo-Saxon minster was not just a single church, but an ecclesiastical zone – often a substantial one – within which churches, chapels and other ritual foci were dispersed alongside accommodation, services and craft buildings. Arrangements of churches were often linear, on a west–east axis. In accordance with that model, I suggested in 1988 that the twelfth-century church of St Frideswide’s priory (now Oxford cathedral), the nucleus of the early minster complex, was the easternmost in a line of churches following the edge of the gravel terrace.
At the start of a new community perinatal mental health service in Scotland we sought the opinions and aspirations of professional and lay stakeholders. A student elective project supported the creation of an anonymous 360-degree online survey of a variety of staff and people with lived experience of suffering from or managing perinatal mental health problems. The survey was designed and piloted with trainees and volunteer patients.
Results
A rich variety of opinions was gathered from the 60 responses, which came from a reasonably representative sample. Respondents provided specific answers to key questions and wrote free-text recommendations and concerns to inform service development.
Clinical implications
There is clear demand for the new expanded service, with strong support for provision of a mother and baby unit in the North of Scotland. The digital survey method could be adapted to generate future surveys to review satisfaction with service development and generate ideas for further change.
Murmann and Vogt's (2022) analysis of the automobile industry using a capabilities framework that integrates both dynamic and ordinary capabilities supports an informative table which sets out the major relevant capabilities that incumbents, start-ups, and diversifying entrants would need to develop or access via contract or other arrangement (see Murmann and Vogt, 2022, Table 3). Jiang and Lu (2022) have further discussed new industry paradigms which they suggest will greatly challenge – and perhaps overwhelm – automotive industry incumbents. We believe that their insights can be taken a step further by focusing on two areas: first, the greatly increased availability of outsourced manufacturing driven by the shift to electric vehicle (‘EV’) powertrains; and second, the ongoing transformation of the driver and passenger experience that is driven by software–user experience software integrated with networked consumer service ecosystems.
Metal-detecting, geophysical survey and small-scale excavation have identified a Romano- British site on a hill-crest above multiple springs. Massive rectilinear rubble platforms, dissected by a complex system of stone-lined drains, suggest large, formal stone buildings, perhaps ritual structures associated with a spring-shrine, but it remains unclear whether the platforms were ever used. Settlement features nearby are dated to the second century. The ploughsoil produced three Iron Age coins, 150 Roman coins and eleven Roman brooches; three Anglo-Saxon pennies (‘sceattas’) of c.730–50 may be the plough-spread remains of a small hoard. The name Showells (Old English seofon wiellan, ‘seven springs’) suggests that the springs also had a ritual aspect in the post-Roman period.
Showells Farm in Crawley (centred SP 342 134) was built between 1767 and 1816 as an isolated field barn; it developed into a farmhouse with a detached cottage in the late nineteenth century, and acquired an extra free-standing house in the mid twentieth. The site is distinctive topographically, but has not hitherto been noted as archaeologically significant. In 2019, however, Len Jackman, a metal-detectorist based in Hailey, reported finding Roman coins and brooches on the hill-crest north-east of the farm. The complexion of this material suggested the possibility of ritual deposition. The interesting fact was then noted that the place-name is of a well-known type meaning ‘seven springs’, suggesting that the springs at the foot of the hill had sacred or ritual associations in the Anglo-Saxon period. Investigations in 2020, including a geophysical survey (magnetometry) and a small exploratory excavation (Trench I), confirmed a Romano-British date for a group of dug features, and found evidence of settlement.
That would have been the end of the project if ground-clearance in 2021 by a new tenant, Kevin Edginton, had not uncovered a stone-built drain below the spring-line. A Roman date for this seemed possible, so a further geophysical survey (resistivity) was undertaken to locate the source of the drain. This revealed something unexpected: a large, and in places clearly rectilinear, high-resistance anomaly aligned on the south-east-facing slope of the spur.
An increasing number of children, adolescents and adults with intellectual disabilities and/or autism are being admitted to general psychiatric wards and cared for by general psychiatrists.
Aims
The aim of this systematic review was to consider the likely effectiveness of in-patient treatment for this population, and compare and contrast differing models of in-patient care.
Method
A systematic search was completed to identify papers where authors had reported data about the effectiveness of in-patient admissions with reference to one of three domains: treatment effect (e.g. length of stay, clinical outcome, readmission), patient safety (e.g. restrictive practices) and patient experience (e.g. patient or family satisfaction). Where possible, outcomes associated with admission were considered further within the context of differing models of in-patient care (e.g. specialist in-patient services versus general mental health in-patient services).
Results
A total of 106 studies were included and there was evidence that improvements in mental health, social functioning, behaviour and forensic risk were associated with in-patient admission. There were two main models of in-patient psychiatric care described within the literature: admission to a specialist intellectual disability or general mental health in-patient service. Patients admitted to specialist intellectual disability in-patient services had greater complexity, but there were additional benefits, including fewer out-of-area discharges and lower seclusion rates.
Conclusions
There was evidence that admission to in-patient services was associated with improvements in mental health for this population. There was some evidence indicating better outcomes for those admitted to specialist services.
USING THE LENS of a feature film to frame her historical interests has been one of Margarethe von Trotta's strengths throughout her career, and this may be part of the reason she has become one of the best-known filmmakers of New German Cinema and “the primary representative of critical German women's film.” Many of her films depict the personal lives of women caught up in the turmoil of their times and emphasize relationships between women. Her films include bio-pics treating the lives of prominent women such as Rosa Luxemburg (1986) or Hannah Arendt (2012), but von Trotta has also created more purely fictional character constellations to illuminate historical periods and subjects: Die bleierne Zeit (Marianne and Julianne, 1981), the co-directed Die verlorene Ehre der Katarina Blum (The Lost Honor of Katarina Blum, 1975), and Schwestern oder die Balance des Glücks (Sisters, or the Balance of Happiness, 1979), for example, examine terrorism in 1970s and 1980s Germany as it reverberates in the lives of female figures. Rosenstrasse (2003) depicts a successful protest during the Third Reich by women who saved their Jewish husbands from deportation. Her 1994 film Das Versprechen (The Promise), the primary focus of this essay, seems less exclusively interested in women's lives and relationships, at least at first glance, but it treats an important and controversial recent historical topic—the Berlin Wall—and constructs a melodramatic love story to make this history personal and palpable to the viewer.
While carrying out a plan to escape from East Berlin into West Berlin soon after the construction of the wall in 1961, Sophie (Meret Becker and Corinna Harfouch) and Konrad (Anian Zollner and August Zirner), two young lovers, are separated. Konrad remains behind in East Berlin and eventually becomes a physics professor of international repute; Sophie becomes the protégée of her aunt in West Berlin, working in the fashion industry. They are able to meet and even live together in Prague for a brief period just before the Prague Spring in 1968. Here, they conceive a child but are then separated again until the fall of the Wall in 1989, with the exception of two brief meetings during a scientific conference in West Berlin that Konrad attends.
This paper aims to demystify the concept of bookland, and to suggest that it matters less for understanding what was distinctive about early England than historians have often supposed. The first part emphasises diplomas as beneficiary-led symbols of culture and status rather than instruments of royal policy. As the primary monastic context faded during the ninth century, so did the distinctive aspects of bookland. By c. 950, bōcland could translate fundus or simply terra, and thereafter diplomas had little effective function beyond signalling the status of landowner and thegn: bookland was absorbed into straightforward allodial possession. In the second part, it is argued that large areas of eastern England never had lay bookland tenure at all, though there was a limited extension of diploma use into parts of the east midlands after c. 940. Rather than a homogeneous Anglo-Saxon charter tradition, we should envisage distinct traditions in the south and west reflecting Italian, Frankish and Brittonic influences. Eastern England, by contrast, faced the North Sea, Scandinavia and the Low Countries: like other English regions it had a high monastic culture during c. 670–800, and that could have included diplomas, but its main documentary tradition is likely to have been more vernacular and decentralized.
THOUGH A FIXTURE in Austrian literary circles, Andrea Grill has yet to receive serious critical attention from scholars. A nominee for the Bachmann Prize (2007) and the winner of the Bremen Literature Prize Advancement Award for up-and-coming authors (2011), she is clearly establishing herself as an author of some importance in Austria and beyond. To date, she has published four novels, two collections of poems, and two collections of travel narratives, among other things. In addition to her literary accomplishments, she holds a PhD in biology, has published numerous articles in that field, and is “interested in change” and “biodiversity.” Indeed what we typically consider scientific methods of observation carry over into stylistic, generic, and content choices in her fiction, particularly in Liebesmaschine N.Y.C. (2012; Love Machine N.Y.C.), creating fertile ground for contributions to the genre(s) of travel writing. This is not to say that she claims scientific objectivity in her literary work—a concept she calls into question throughout the collection Liebesmaschine N.Y.C.—but that her stories of travel can be read as the study of a certain habitat, its biodiversity, and the labors of new arrival. Like Peter Handke in Der kurze Brief zum langen Abschied (1972; Short Letter, Long Farewell), she interweaves philosophical musings on identity with matter-of-fact descriptions of often unspectacular aspects of life in the United States, foregrounding that the objects of her observations and study in Liebesmaschine are not just the places to which she travels but she herself and, most significantly, the dynamic interaction between the two, both intellectually and physically. Here we emphasize how she explores not only her literal travel and movement in the external world but also how it precipitates internal movement: psychic and intellectual reactions to the rhythms around her. Her stream-of-conscousness-like narratives reconceive travel as a model for understanding the self and others. Embracing ambivalence and ambiguity as textual principles that mimic movement, Grill implicitly proposes a model for a utopian epistemology. The collection as a whole can be understood as a process of demonstrating rather than explaining. In Liebesmaschine, travel writing becomes a series of disparate meditations on identity (national and personal), the forces that shape specific environments, and the interplay between them.
Driving in persons with dementia poses risks that must be counterbalanced with the importance of the care for autonomy and mobility. Physicians often find substantial challenges in the assessment and reporting of driving safety for persons with dementia. This paper describes a driving in dementia decision tool (DD-DT) developed to aid physicians in deciding when to report older drivers with either mild dementia or mild cognitive impairment to local transportation administrators.
Methods:
A multi-faceted, computerized decision support tool was developed, using a systematic literature and guideline review, expert opinion from an earlier Delphi study, as well as qualitative interviews and focus groups with physicians, caregivers of former drivers with dementia, and transportation administrators. The tool integrates inputs from the physician-user about the patient's clinical and driving history as well as cognitive findings, and it produces a recommendation for reporting to transportation administrators. This recommendation is translated into a customized reporting form for the transportation authority, if applicable, and additional resources are provided for the patient and caregiver.
Conclusions:
An innovative approach was needed to develop the DD-DT. The literature and guideline review confirmed the algorithm derived from the earlier Delphi study, and barriers identified in the qualitative research were incorporated into the design of the tool.
Woody plant herbicide screening techniques were evaluated to expedite the screening process and decrease amounts of herbicide active ingredient required. Rapid greenhouse screening of woody plant seedlings was performed in less than 6 months, and rapid seed screening was performed in less than 20 days. A traditional field screen, requiring 10 months from application to final evaluation, was performed for comparison and regression modeling purposes. Imazapyr and triclopyr were used as test chemicals and linear regressions were generated to predict traditional field screen results from rapid screens. Significant regressions were produced that predicted field responses of loblolly pine, sweetgum, and yellow-poplar with the use of both herbicides and either rapid screening technique. This indicated that rapid screening techniques could determine herbicide efficacy and/or species spectrum in much less time with significantly less herbicide. Rapid greenhouse screens of triclopyr produced more statistically significant regressions than those using imazapyr. Rapid seed screens could estimate species spectrum within 5 days after treatment. These results indicate that rapid greenhouse screen and rapid seed screen techniques can provide woody plant herbicide developers initial efficacy and spectrum of control data in a cost- and-time effective manner.
Field experiments from 1997 to 1999 examined cotton cv. ‘Coker 312’ that was genetically transformed to tolerate glufosinate. None of the glufosinate treatments caused visible injury to the glufosinate-tolerant cotton, but treatments were lethal to nontransformed or nonexpressing cotton. No glufosinate treatment adversely affected plant height at maturity, total number of nodes, bolls per plant, or boll positions. Glufosinate applications of 0.6 kg ha−1 made at eight stages of growth, ranging from cotyledon stage to 50% open boll, did not adversely affect yield or fiber quality as measured by micronaire or fiber length and strength. Sequential glufosinate applications up to four stages of growth from the zero- to one-leaf stage to the 14- to 15-leaf stage or individual glufosinate applications at 3.3 kg ha−1 made at the two- to three-leaf stage of growth also did not adversely affect yield or fiber quality. Overall yields in these studies were low relative to normal Texas Southern High Plains cotton yield because these studies were conducted using a Coker 312 parental line, which is generally a poor performer in this region. This research indicated that the transformation events for glufosinate tolerance in cotton were successful and the glufosinate-tolerance gene was expressed throughout the growing season. Transformation and field testing of other cotton varieties are needed to improve varietal performance on the Texas Southern High Plains.
The asphalt deposits of Rancho La Brea are well known for preserving a prolific and diverse Late Pleistocene fauna. However, little taphonomic research has been done on these collections. To better understand the formation of this impressive assemblage, a taphonomic study of the bones of the large mammals from one asphalt deposit, Pit 91, was carried out, and results are presented here. The predominance of carnivore specimens in the Rancho La Brea deposits has long been explained by a scenario in which a prey animal was trapped in asphalt and attracted large numbers of carnivores who became trapped in turn. Hypotheses generated from this scenario were tested by collecting taphonomic data on over 18,000 specimens. Weathering data indicate that elements were deposited fairly rapidly. However, patterns of skeletal part representation for the seven most common species demonstrate that complete skeletons are not present. Water transport is ruled out as the primary process responsible for removing skeletal elements based on abrasion data. Instead, the feeding activity of carnivores (ravaging) appears to have been an important factor in the formation of the assemblage.
An infant of a diabetic mother lived 13 days after birth. She had a small dysplastic 12.6 gm. brain, partly forming a frontal encephalocele. The uncleaved forebrain contained a mass of poorly organized heterotopic cerebellar cortex. The cerebellum itself had normal lamination, but was small and continuous with the dysplastic tissue. The ventricular system was absent except for a few midline ependymal rosettes, and the cerebral cortex was not developed. The cerebellar dysplasia resembled a proliferative and invasive lesion by its rostral extension.
In this study, we used farm-level data from a university feed-out program to evaluate how the value of feeder cattle ultimately realized through finishing and grid pricing differs from their market value at public auction. Consistent with the theory of factor price disparity, results indicate that significant risk premiums exist in the feeder cattle market. Producers of cattle with known feedlot performance, carcass potential, or both might be better off retaining ownership of their calves or marketing them in a way that communicates the information that is known about their potential performance directly to the buyer.