A tabletop prototype of a roll-to-roll (R2R) direct stamping apparatus has been developed. The prototype is about 100 cm long, 30 cm wide and 40 cm high and is operational up to the web speed of 1 m/min. While upper rolls carry a web with a patterned stamp on it clockwise, a sprayer on top of the R2R apparatus dispenses the nano-ink to fill in the stamp. Two other rolls with adhesive films completely remove the residual layer on the stamp. Final products remain on the substrate after de-stamping in which the web rolls up and the substrate moves to the further right. This roll-to-roll direct stamping apparatus demonstrates high throughput and material efficiency for fabrication of flexible micro- and nano-electronic devices.