Trifluralin is used for weed control in wheat but may reduce vegetative growth and yield. Postemergence (POST) herbicides may cause additional plant stress to trifluralin-stressed wheat. Field studies at Groton, SD in 1991 and 1992 and at Highmore, SD in 1992 evaluated the effects of 2,4-D-amine, difenzoquat, metsulfuron, and a combination of fenoxaprop-ethyl + 2,4-D-ester + MCPA-ester on hard red spring wheat cultivars ‘2375,’ ‘Prospect,’ and ‘Butte 86’ seeded in areas treated with preplant incorporated trifluralin either in the spring before seeding (0.56 kg ai/ha) or the previous year (1.12 or 2.24 kg ai/ha). Trifluralin applied alone in the spring, and followed by some POST herbicides, reduced shoot dry weight and grain yield. Trifluralin reduced the yield of Prospect the most and the yield of 2375 the least. Yields of trifluralin-treated wheat were reduced 23% by metsulfuron and 14% by fenoxaprop-ethyl + 2,4-D + MCPA compared to yields of wheat treated with only the respective POST herbicide. Yields were not reduced with any trifluralin-POST herbicide combination when trifluralin was applied a year prior to seeding wheat.