In recent years, Asian criminology and Southern criminology have drawn scholarly attention to the profound divide between Western and non-Western societies, or the Global North and Global South, in criminological knowledge production. Perspectives from Asian and Southern criminology expose these divides and propose critical ways to correct the hegemony of Western over non-Western, or Northern over Southern, knowledge production. For the contemporary movement of decolonization of knowledge, a particular contribution of Asian criminology is to link Western and non-Western, or Northern and Southern, criminological science. As Sandra Walklate concluded, “Asian criminology … stands at the positive intersection of the north–south and east–west in terms of geography and culture. It is well placed to think differently, both conceptually and methodologically, about the criminological enterprise, and the debates that such different thinking might generate.” This article reviews the divide in criminology between the Global North and South. Based on the framework of the Asian criminological paradigm, Asian criminology has made major contributions to bridging the divide between the North and the South through academic institutionalization and theoretical development strategies.

The nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) signaling pathway, which is conserved in invertebrates, plays a significant role in human diseases such as inflammation-related diseases and carcinogenesis. Angiogenesis refers to the growth of new capillary vessels derived from already existing capillaries and postcapillary venules. Maintaining normal angiogenesis and effective vascular function is a prerequisite for the stability of organ tissue function, and abnormal angiogenesis often leads to a variety of diseases. It has been suggested that NK-κB signalling molecules under pathological conditions play an important role in vascular differentiation, proliferation, apoptosis and tumourigenesis by regulating the transcription of multiple target genes. Many NF-κB inhibitors are being tested in clinical trials for cancer treatment and their effect on angiogenesis is summarised. In this review, we will summarise the role of NF-κB signalling in various neovascular diseases, especially in tumours, and explore whether NF-κB can be used as an attack target or activation medium to inhibit tumour angiogenesis.

HIV-1 molecular surveillance provides a new approach to explore transmission risks and targeted interventions. From January to June 2021, 663 newly reported HIV-1 cases were recruited in Zhaotong City, Yunnan Province, China. The distribution characteristics of HIV-1 subtypes and HIV-1 molecular network were analysed. Of 542 successfully subtyped samples, 12 HIV-1 strains were identified. The main strains were CRF08_BC (47.0%, 255/542), CRF01_AE (17.0%, 92/542), CRF07_BC (17.0%, 92/542), URFs (8.7%, 47/542), and CRF85_BC (6.5%, 35/542). CRF08_BC was commonly detected among Zhaotong natives, illiterates, and non-farmers and was mostly detected in Zhaoyang County. CRF01_AE was frequently detected among married and homosexual individuals and mostly detected in Weixin and Zhenxiong counties. Among the 516 pol sequences, 187 (36.2%) were clustered. Zhaotong natives, individuals aged ≥60 years, and illiterate individuals were more likely to be found in the network. Assortativity analysis showed that individuals were more likely to be genetically associated when stratified by age, education level, occupation, and reporting area. The genetic diversity of HIV-1 reflects the complexity of local HIV epidemics. Molecular network analyses revealed the subpopulations to focus on and the characteristics of the risk networks. The results will help optimise local prevention and control strategies.

The purpose of this study is to further investigate the relationship between sweetener exposure and the risk of endometrial cancer (EC). Up until December 2022, a literature search in an electronic database was carried out utilizing PubMed, Web of Science, Ovid, and Scopus. The odds ratio (OR) and 95 % confidence interval (CI) were used to evaluate the results. Sweeteners were divided into nutritional sweeteners (generally refers to sugar, such as sucrose and glucose) and non-nutritional sweeteners (generally refers to artificial sweeteners, such saccharin and aspartame). Ten cohort studies and two case-control studies were eventually included. The study found that in 12 studies, compared with the non-exposed group, the incidence rate of EC in the sweetener exposed group was higher (OR = 1·15, 95 % CI = [1·07, 1·24]). Subgroup analysis showed that in 11 studies, the incidence rate of EC in the nutritional sweetener exposed group was higher than that in the non-exposed group (OR = 1·25, 95 % CI = [1·14, 1·38]). In 4 studies, there was no difference in the incidence rate of EC between individuals exposed to non-nutritional sweeteners and those who were not exposed to non-nutritional sweeteners (OR = 0·90, 95 % CI = [0·81, 1·01]). This study reported that the consumption of nutritional sweeteners may increase the risk of EC, whereas there was no significant relationship between the exposure of non-nutritional sweeteners and the incidence of EC. Based on the results of this study, it is recommended to reduce the intake of nutritional sweeteners, but it is uncertain whether use of on-nutritional sweeteners instead of nutritional sweetener.

Relativistic few-cycle mid-infrared (mid-IR) pulses are unique tools for strong-field physics and ultrafast science, but are difficult to generate with traditional nonlinear optical methods. Here, we propose a scheme to generate such pulses with high efficiency via plasma-based frequency modulation with a negatively chirped laser pulse (NCLP). The NCLP is rapidly compressed longitudinally due to dispersion and plasma etching, and its central frequency is downshifted via photon deceleration due to the enhanced laser intensity and plasma density modulations. Simulation results show that few-cycle mid-IR pulses with the maximum center wavelength of $7.9\;\unicode{x3bc} \mathrm{m}$ and pulse intensity of ${a}_{\mathrm{MIR}}=2.9$ can be generated under a proper chirp parameter. Further, the maximum energy conversion efficiency can approach 5.0%. Such a relativistic mid-IR source is promising for a wide range of applications.

OBJECTIVES/GOALS: Single-cell and spatial transcriptomics have revealed high heterogeneity in the tumor and microenvironment. Identifying populations of cells that impact a patient’s prognosis is an important research goal, so researchers can generate hypotheses and clinicians can provide targeted treatment. METHODS/STUDY POPULATION: DEGAS uses deep-transfer-learning to identify patterns between patient tumor RNA-seq and clinical outcomes and map these associations on to higher-resolution data like spatial and single-cell transcriptomics. We apply DEGAS to prostate and pancreatic cancer spatial transcriptomics samples, as well as one normal sample of prostate tissue. We used the TCGA prostate cancer cohort to with the accompanying survival information and publicly accessible prostate cancer ST data from 10X Genomics to predict survival associations in the ST slides derived from the TCGA patients. Based on these survival associations, we identify higher risk subsections of ST slides which can be further studied. RESULTS/ANTICIPATED RESULTS: We were able to validate our method by comparing it to Scissor and were able to show that the number of high-risk regions in prostate cancer slides increased with the stage of disease. Furthermore, we identify transcriptomic signatures enriched for ontology terms associated with growth regulation and apoptosis, inflammation, immune signaling, and autophagy in histologically normal prostate tissues and adjacent normal pancreatic cancer tissues that were identified as high-risk by DEGAS. The regions highlighted by DEGAS could reflect transcriptional precursors to intraepithelial neoplasia–a well-recognized premalignant morphological change in glandular epithelium. DISCUSSION/SIGNIFICANCE: Identifying biomarkers of tissue stress that precede morphologic diagnosis of high-grade pre-malignant lesions by a pathologist may help triage patients at high risk for future development of cancer, or aid in better understanding whether histologically normal pre-malignant tissues at tumor margins contribute to recurrence.

Nitrogen fertilizer and water are two major nutrients required for the optimal production of rice worldwide. The utilization of different irrigation techniques to save water and fertigation to maximize rice production has been the main focus. A field experiment was conducted to explore the responses of 16 rice varieties to different irrigation and nitrogen fertilizer regimes. Two nitrogen treatments, 270 kg ha−1 and 225 kg ha−1 (urea N ≥ 46.4%), and two irrigation regimes, 8.7 t ha−1 and 5.22 t ha−1, were applied three times. Plant height and the soil and plant analyser development (SPAD) values were measured throughout the growth period. The total yield and quality characteristics of the rice varieties were also determined. Based on the yield, the 16 rice varieties were divided into three groups: high yield (I), middle yield (II) and low yield (III) using cluster analysis. A positive correlation was found between the growth period and yield of these 16 rice varieties. In the water-deficient regime, the growth period of the 16 varieties was reduced by 1.68–2.93%. Furthermore, nitrogen- and water-deficient regimes had significant effects on the polishing rate, protein content and taste values of all varieties. At maturity stage under these regimes, plant height and chlorophyll SPAD values were decreased by 1.25–6.05% and 1.60–31.48%, respectively. Deficient nitrogen fertilization, along with appropriate irrigation, is an effective method for the efficient utilization of irrigation and fertilizer resources in rice-growing areas.

A 2 × 2 dual band MIMO flexible antenna with a low profile and CPW feeding is designed for Internet of Things (IoT) domains, operating in 5G (3.3–3.6/4.8–5.0 GHz), WiMAX (5.25–5.85 GHz) and WLAN (5.15–5.35/5.725–5.825 GHz) bands. Two resonant frequencies are generated by L-shaped branches and a rectangular monopole. The mentioned MIMO antenna comprises four elements arranged vertically. With the addition of an orthogonal branch, significant isolation is attained, which exceeds 21 dB in the entire bands. The four-element MIMO antenna is fabricated and experimented to analyze the performance. According to the measurement, the antenna can operate bandwidth covering 3.156–3.84 GHz (19.55%) and 4.638–6.348 GHz (31.13%). Furthermore, the provided four-element MIMO antenna possesses a number of advantageous properties, such as ECC, DG, and TARC, indicating its suitability for 5G/WiMAX/WLAN applications. In accordance with the results of bending measurement and human body influence, it is evident that the presented liquid crystal polymer antenna could be an ideal candidate for integrating into wearable 5G/WiMAX/WLAN devices.

In this study, the length scaling for the boundary layer separation induced by two incident shock waves is experimentally and analytically investigated. The experiments are performed in a Mach 2.73 flow. A double-wedge shock generator with two deflection angles ($\alpha _1$ and $\alpha _2$) is employed to generate two incident shock waves. Two deflection angle combinations with an identical total deflection angle are adopted: ($\alpha _1 = 7^\circ$, $\alpha _2 = 5^\circ$) and ($\alpha _1 = 5^\circ$, $\alpha _2 = 7^\circ$). For each deflection angle combination, the flow features of the dual-incident shock wave–turbulent boundary layer interactions (dual-ISWTBLIs) under five shock wave distance conditions are examined via schlieren photography, wall-pressure measurements and surface oil-flow visualisation. The experimental results show that the separation point moves downstream with increasing shock wave distance ($d$). For the dual-ISWTBLIs exhibiting a coupling separation state, the upstream interaction length ($L_{int}$) of the separation region approximately linearly decreases with increasing $d$, and the decrease rate of $L_{int}$ with $d$ increases with the second deflection angle under the condition of an identical total deflection angle. Based on control volume analysis of mass and momentum conservations, the relation between $L_{int}$ and $d$ is analytically determined to be approximately linear for the dual-ISWTBLIs with a coupling separation region, and the slope of the linear relation obtained analytically agrees well with that obtained experimentally. Furthermore, a prediction method for $L_{int}$ of the dual-ISWTBLIs with a coupling separation region is proposed, and the relative error of the predicted $L_{int}$ in comparison with the experimental result is $\sim$10 %.

We present experimental results of irregular long-crested waves propagating over a submerged trapezoidal bar with the presence of a background current in a wave flume. We investigate the non-equilibrium phenomenon (NEP) induced by significant changes of water depth and mean horizontal flow velocity as wave trains pass over the bar. Using skewness and kurtosis as proxies, we show evidence that an accelerating following current could increase the sea-state non-Gaussianity and enhance both the magnitude and spatial extent of the NEP. We also find that below a ‘saturation relative water depth’ $k_p h_2 \approx 0.5$ ($k_p$ being the peak wavenumber in the shallow area of depth $h_2$), although the NEP manifests, the decrease of the relative water depth does not further enhance the maximum skewness and kurtosis over the bar crest. This work highlights the nonlinear physics according to which a following current could provoke higher freak wave risk in coastal areas where modulation instability plays an insignificant role.

The associations of red/processed meat consumption and cancer-related health outcomes have been well discussed. The umbrella review aimed to summarise the associations of red/processed meat consumption and various non-cancer-related outcomes in humans. We systematically searched the systematic reviews and meta-analyses of associations between red/processed meat intake and health outcomes from PubMed, Embase, Web of Science and the Cochrane Library databases. The umbrella review has been registered in PROSPERO (CRD 42021218568). A total of 40 meta-analyses were included. High consumption of red meat, particularly processed meat, was associated with a higher risk of all-cause mortality, CVD and metabolic outcomes. Dose–response analysis revealed that an additional 100 g/d red meat intake was positively associated with a 17 % increased risk of type 2 diabetes mellitus (T2DM), 15 % increased risk of CHD, 14 % of hypertension and 12 % of stroke. The highest dose–response/50 g increase in processed meat consumption at 95 % confident levels was 1·37, 95 % CI (1·22, 1·55) for T2DM, 1·27, 95 % CI (1·09, 1·49) for CHD, 1·17, 95 % CI (1·02, 1·34) for stroke, 1·15, 95 % CI (1·11, 1·19) for all-cause mortality and 1·08, 95 % CI (1·02, 1·14) for heart failure. In addition, red/processed meat intake was associated with several other health-related outcomes. Red and processed meat consumption seems to be more harmful than beneficial to human health in this umbrella review. It is necessary to take the impacts of red/processed meat consumption on non-cancer-related outcomes into consideration when developing new dietary guidelines, which will be of great public health importance. However, more additional randomised controlled trials are warranted to clarify the causality.

Liriomyza trifolii is a significant pest of vegetable and ornamental crops across the globe. Microwave radiation has been used for controlling pests in stored products; however, there are few reports on the use of microwaves for eradicating agricultural pests such as L. trifolii, and its effects on pests at the molecular level is unclear. In this study, we show that microwave radiation inhibited the emergence of L. trifolii pupae. Transcriptomic studies of L. trifolii indicated significant enrichment of differentially expressed genes (DEGs) in ‘post-translational modification, protein turnover, chaperones’, ‘sensory perception of pain/transcription repressor complex/zinc ion binding’ and ‘insulin signaling pathway’ when analyzed with the Clusters of Orthologous Groups, Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes databases, respectively. The top DEGs were related to reproduction, immunity and development and were significantly expressed after microwave radiation. Interestingly, there was no significant difference in the expression of genes encoding heat shock proteins or antioxidant enzymes in L. trifolii treated with microwave radiation as compared to the untreated control. The expression of DEGs encoding cuticular protein and protein takeout were silenced by RNA interference, and the results showed that knockdown of these two DEGs reduced the survival of L. trifolii exposed to microwave radiation. The results of this study help elucidate the molecular response of L. trifolii exposed to microwave radiation and provide novel ideas for control.

The influence of second-order dispersion (SOD) on stimulated Raman scattering (SRS) in the interaction of an ultrashort intense laser with plasma was investigated. More significant backward SRS was observed with the increase of the absolute value of SOD ($\mid \kern-1pt\!{\psi}_2\!\kern-1pt\mid$). The integrated intensity of the scattered light is positively correlated to the driver laser pulse duration. Accompanied by the side SRS, filaments with different angles along the laser propagation direction were observed in the transverse shadowgraph. A model incorporating Landau damping and above-threshold ionization was developed to explain the SOD-dependent angular distribution of the filaments.

A pulsed fast neutron source is critical for applications of fast neutron resonance radiography and fast neutron absorption spectroscopy. However, due to the large transversal source size (of the order of mm) and long pulse duration (of the order of ns) of traditional pulsed fast neutron sources, it is difficult to realize high-contrast neutron imaging with high spatial resolution and a fine absorption spectrum. Here, we experimentally present a micro-size ultra-short pulsed neutron source by a table-top laser–plasma wakefield electron accelerator driving a photofission reaction in a thin metal converter. A fast neutron source with source size of approximately 500 μm and duration of approximately 36 ps has been driven by a tens of MeV, collimated, micro-size electron beam via a hundred TW laser facility. This micro-size ultra-short pulsed neutron source has the potential to improve the energy resolution of a fast neutron absorption spectrum dozens of times to, for example, approximately 100 eV at 1.65 MeV, which could be of benefit for high-quality fast neutron imaging and deep understanding of the theoretical model of neutron physics.

A welding path can be planned effectively for spot welding robots using the ant colony algorithm, but the initial parameters of the ant colony algorithm are usually selected through human experience, resulting in an unreasonable planned path. This paper combines the ant colony algorithm with the particle swarm algorithm and uses the particle swarm algorithm to train the initial parameters of the ant colony algorithm to plan an optimal path. Firstly, a mathematical model for spot welding path planning is established using the ant colony algorithm. Then, the particle swarm algorithm is introduced into the ant colony algorithm to find the optimal combination of parameters by treating the initial parameters $\alpha$ and $\beta$ of the ant colony algorithm and as two-dimensional coordinates in the particle swarm algorithm. Finally, the simulation analysis was carried out using MATLAB to obtain the paths of the improved ant colony algorithm for six different sets of parameters with an average path length of 10,357.7509 mm, but the average path length obtained by conventional algorithm was 10,830.8394 mm. Convergence analysis of the improved ant colony algorithm showed that the average number of iterations was 17. Therefore, the improved ant colony algorithm has higher solution quality and converges faster.

Socially responsible (SR) institutions tend to focus more on the environmental, social, and governance (ESG) performance and less on quantitative signals of value. Consistent with this difference in focus, we find that SR institutions react less to quantitative mispricing signals. Our evidence suggests that the increased focus on ESG may have influenced stock return patterns. Specifically, abnormal returns associated with these mispricing signals are greater for stocks held more by SR institutions. The link between SR ownership and the efficacy of mispricing signals only emerges in recent years with the rise of ESG investing, and is significant only when there are arbitrage-related funding constraints.