Introduction: White matter hyperintensities (WMHs) were commonly seen in brain magnetic resonance imaging (MRI) of the elderly. Many studies found that WMHs were associated with cognitive decline and dementia. However, the association between WMHs in different brain regions and cognitive decline remains debated. Methods: We explored the association of the severity of WMHs and cognitive decline in 115 non-demented elderly (≥50 years old) sampled from the Wuliqiao Community located in urban area of Shanghai. MRI scans were done during 2009–2011 at the beginning of the study. Severity of WMHs in different brain regions was scored by Improved Scheltens Scale and Cholinergic Pathways Hyperintensities Scale (CHIPS). Cognitive function was evaluated by Mini-Mental State Examination (MMSE) every 2 to 4 years during 2009–2018. Results: After adjusting for confounding factors including age, gender, education level, smoking status, alcohol consumption, depression, hypertension, diabetes, hyperlipidemia, brain infarcts, brain atrophy, apoE4 status, and baseline MMSE score, periventricular and subcortical WMH lesions as well as WMHs in cholinergic pathways were significantly associated with annual MMSE decline ( p < 0.05), in which the severity of periventricular WMHs predicted a faster MMSE decline (–0.187 points/year, 95% confidence interval: –0.349, –0.026, p = 0.024). Conclusions: The severity of WMHs at baseline was associated with cognitive decline in the non-demented elderly over time. Interventions on WMH lesions may offer some benefits for cognitive deterioration.

Highly dense zirconia dental ceramic coatings were fabricated by aqueous electrophoretic deposition (EPD) and subsequently sintered between 1250 and 1450 °C. Microstructural examination revealed that aqueous EPDZrO2 coatings possessed a tetragonal phase structure and the grain size increased with increasing sintering temperature. Nanoindentation study proved that the aqueous EPDZrO2 coating also had excellent mechanical properties. The effect of different applied loads on hardness and elastic modulus of the 1350 °C-sintered sample at room temperature was investigated by the method of progressive multicycle measurement nanoindentation. The simulative experiment proved that hardness of aqueous EPDZrO2 exhibited reverse indentation size effect (ISE) behavior and then displayed the normal ISE response. The analysis indicates that the reverse ISE is attributed to the relaxation of surface stresses resulting from indentation cracks at small loads and normal ISE is caused by geometrically necessary dislocations. The tetragonal–monoclinic stress-induced phase transformation during nanoindentation is the primary cause of dental zirconia failures.

AlMg alloys have widespread industrial applications. Grain refinement techniques have been frequently used to achieve high strength in these alloys. Here, we report on the fabrication of epitaxial co-sputtered AlMg thin films with high-density growth twins. The microstructure evolution with varying Mg composition has been characterized. Nanoindentation and in-situ micropillar compression tests show that the strength of AlMg alloys increases with increasing Mg composition. The flow stress of epitaxial nanotwinned Al–10 at.% Mg thin film exceeds 800 MPa. The modified Hall–Petch plots incorporating the solid solution strengthening effect suggest that, compared to high angle grain boundaries, incoherent twin boundaries are equivalent barriers to the transmission of dislocations in nanotwinned AlMg alloys.

Astrophysical collisionless shocks are amazing phenomena in space and astrophysical plasmas, where supersonic flows generate electromagnetic fields through instabilities and particles can be accelerated to high energy cosmic rays. Until now, understanding these micro-processes is still a challenge despite rich astrophysical observation data have been obtained. Laboratory astrophysics, a new route to study the astrophysics, allows us to investigate them at similar extreme physical conditions in laboratory. Here we will review the recent progress of the collisionless shock experiments performed at SG-II laser facility in China. The evolution of the electrostatic shocks and Weibel-type/filamentation instabilities are observed. Inspired by the configurations of the counter-streaming plasma flows, we also carry out a novel plasma collider to generate energetic neutrons relevant to the astrophysical nuclear reactions.

The effect of nitrogen gas addition in Ar-based double-layer shielding gas on the impact toughness of welded ultra-ferritic stainless steel during an autogenous gas tungsten arc welding (GTAW) process was investigated. The nitrogen behavior was proposed. The microstructure, mechanical properties, and fracture surface morphology of the weld metals have been evaluated. More equiaxed crystals, refined grain, narrow HAZ width, and increased microhardness were produced with nitrogen addition. Experimental findings indicated that nitrogen diffused into HAZ and dissolved into weld pool. The solute distribution was changed thus bringing significant constitutional supercooling and decreased temperature gradient of weld pool, which contributed to fine microstructure. Impact toughness at room temperature was enhanced from 2J to 9J (welds), 5J–13J (HAZ). Ductile fracture zone was produced about 0.3–0.5 mm thickness distance from the weld surface. A significant increased impact toughness of weld metal was due to the refinement of microstructure and element addition.

Accurate and reliable dating of paleosols, animal remains, and artifacts is of crucial importance in reconstructing environmental change and understanding the interrelationship between human activities and natural environments. Dating different materials in the same sample can help resolve problems such as soil carbon sources and carbon storage state. Conventional radiocarbon dating of soil (inorganic and organic matter) and accelerator mass spectrometry (AMS) dating of animal remains (fossil bones and teeth) result in different ages for materials from the same sample position in a typical loess section at Xinglong Mountain, Yuzhong County, Gansu Province in NW China. Inorganic matter is ∼3400 yr older than organic matter, 4175 ± 175 cal BP to 3808 ± 90 cal BP. A 1610-yr difference between the 14C ages of fossils (animal bones and teeth) and soil organic matter suggests that a depositional hiatus exists in the studied profile. The varying 14C ages of fossils and soil organic and inorganic matter have important implications for paleoclimate reconstructions from loess sections. It is critical to consider the meaning of the variable 14C ages from different material components from the same sample position in terms of soil organic and inorganic carbon storage, vegetation history reconstruction, archaeology, and the study of ancient civilizations.

A correction method for linear hardening materials is brought forward to obtain the true (or nearly true) modulus of cylindrical specimens with middle aspect ratios in compression tests. By considering the stress concentration near the interface between the specimen and the compression platen caused by slanted contact, a “sandwich” model is developed. A correction formula is derived and all parameters can be obtained from the tested stress–strain curve. Experiments were performed on Al 2024 specimens with four aspect ratios. The corrected results are closer to the intrinsic modulus than the tested values, which verify the effectiveness of the correction method.

Toxoplasma gondii is a major cause of congenital brain disease; however, the underlying mechanism of neuropathogenesis in brain toxoplasmosis remains elusive. To explore the role of T. gondii in the development of neural stem cells (NSCs), NSCs were isolated from GD14 embryos of ICR mice and were co-cultured with tachyzoites of T. gondii RH strain. We found that apoptosis levels of the NSCs co-cultured with 1×106 RH tachyzoites for 24 and 48 h significantly increased in a dose-dependent manner, as compared with the control. Western blotting analysis displayed that the protein level of C/EBP homologous protein (CHOP) was up-regulated, and caspase-12 and c-Jun N-terminal kinase (JNK) were activated in the NSCs co-cultured with the parasites. Pretreatment with endoplasmic reticulum stress (ERS) inhibitor (TUDCA) and caspase-12 inhibitor (Z-ATAD-FMK) inhibited the expression or activation of the key molecules involved in the ERS-mediated apoptotic pathway, and subsequently decreased the apoptosis levels of the NSCs induced by the T. gondii. The findings here highlight that T. gondii induced apoptosis of the NSCs through the ERS signal pathway via activation of CHOP, caspase-12 and JNK, which may constitute a potential molecular mechanism responsible for the cognitive disturbance in neurological disorders of T. gondii.

The driving mechanism of solar flares and coronal mass ejections is a topic of ongoing debate, apart from the consensus that magnetic reconnection plays a key role during the impulsive process. While present solar research mostly depends on observations and theoretical models, laboratory experiments based on high-energy density facilities provide the third method for quantitatively comparing astrophysical observations and models with data achieved in experimental settings. In this article, we show laboratory modeling of solar flares and coronal mass ejections by constructing the magnetic reconnection system with two mutually approaching laser-produced plasmas circumfused of self-generated megagauss magnetic fields. Due to the Euler similarity between the laboratory and solar plasma systems, the present experiments demonstrate the morphological reproduction of flares and coronal mass ejections in solar observations in a scaled sense, and confirm the theory and model predictions about the current-sheet-born anomalous plasmoid as the initial stage of coronal mass ejections, and the behavior of moving-away plasmoid stretching the primary reconnected field lines into a secondary current sheet conjoined with two bright ridges identified as solar flares.

Diamond is a metastable phase, while graphite is a stable phase in low pressure equilibrium phase diagrams of carbon. However, diamond with saturated structure of π bonds is more stable than graphite with unsaturated structure of n bonds during the existence of activated particles generated by plasma. That provides an excellent explanation for the plasma and other activated CVD diamond growth under low pressure taking place with simultaneous graphite etching.

The influence of shot peening (SP) on high cycle fatigue (HCF) performance of smooth and notched specimens of hot-extruded ZK60 magnesium alloy was investigated and compared to that of hot-extruded and T5 aging-treated ZK60 magnesium alloy referred to as ZK60-T5. The increases in fatigue properties at the optimum Almen intensities were found to depend on the material states. In contrast to ZK60 alloy, higher smooth and notched fatigue properties for both unpeened and peened specimens were observed for ZK60-T5 alloy. Meanwhile, the improvement of fatigue life for notched specimen by SP was much more than that for the smooth specimen. The mechanism by which the compressive residual stress induced by SP resulted in the improvement of fatigue performance of smooth and notched specimens for ZK60 and ZK60-T5 alloys was discussed.

Particle-containing silica sol was synthesized by co-hydrolysis and co-condensation of two silane precursors, tetraethylorthosilicate (TEOS) and an organic silane composed of a non-hydrolyzable functional group (e.g., alkyl, fluorinated alkyl, and phenyl), and used to produce superhydrophobic coatings on fabrics. It has been revealed that the non-hydrolyzable functional groups in the organic silanes have a considerable influence on the fabric surface wettability. When the functional group was long chain alkyl (C16), phenyl, or fluorinated alkyl (C8), the treated surfaces were highly superhydrophobic with a water contact angle (CA) greater than 170°, and the CA value was little affected by the fabric type. The washing durability of the superhydrophobic coating was improved by introducing the third silane containing epoxide group, 3-glycidoxypropyltrimethoxysilane (GPTMS), for synthesis. Although the presence of epoxide groups in the coating slightly reduced the fabrics' superhydrophobicity, the washing durability was considerably improved when polyester and cotton fabrics were used as substrates.

In this study, the influence of T5 heat treatment on tensile and fatigue behavior of hot-extruded Mg–10Gd–3Y (wt%) magnesium alloy has been investigated. High cycle fatigue tests were carried out at a stress rate (R) of −1 and a frequency of 100 Hz using hour-glass-shaped round specimens with a gauge diameter of 5.8 mm. The results show that fatigue strength (at 107 cycles) of Mg–10Gd–3Y magnesium alloy increases from 150 to 165 MPa after T5 heat treatment, i.e., the improvement of 10% in fatigue strength has been achieved. However, the crack growth resistance is lowered by T5 heat treatment. Results of microstructure observation and scanning electron microscopy-energy dispersive x-ray (SEM-EDX) analysis suggest that the fatigue strength in the Mg–10Gd–3Y magnesium alloy is determined by the threshold stress of basal slip, which is induced by solid solution hardening and precipitation hardening.

In this paper we consider the problem of finding the optimal order for two servers in series when there is no queue capacity. We show that it is better for the faster server to be first. The strength of this conclusion will depend on the strength of the assumption made about the service distribution. We also find the optimal order for some systems where both servers have the same average service time and different service distributions.

We consider tandem queueing systems with a general arrival process and exponential service distribution. The queueing system consists of several stations with finite intermediate buffer capacity between the stations. We address the problem of determining the optimal arrangement for the stations. We find that considering the last two stations, the departure process is stochastically faster if the slower station is last. Our results are consistent with the “bowl shape” phenomenon that has been observed in serial queueing systems with zero buffer capacity.