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The edge surface warping defect seriously affect the surface quality of strips. In this paper, a technology for diagnosis of warping defects in hot-rolled strip based on data-driven methods is studied. Based on the mechanism analysis of the warping defects, the process parameters affecting the warping defects were sorted out and used as the original input parameters of the defect diagnosis model. Firstly, a diagnostic model that combines the deep belief network and contribution plots of each dimensionality reduction layer is proposed. The deep belief network that integrates each dimensionality reduction layer can predict product defects more accurately and stably than the traditional deep belief network. Meanwhile, on the basis of the pre-judgment model, the method of contribution plot is further introduced to trace the defects, and the comprehensive diagnosis function of model pre-judgment and traceability is realized. Finally, collected the production data from a hot rolling production line for a period of time. Tested the model and predicted a hit rate of 85%. The main influencing factors of edge surface warping defects were determined that the rate of defect decrease with the increase of furnace temperature. When the heating temperature of the second stage of the heating furnace is higher than 1160°C, the incidence of defects is significantly reduced. Defect rate is relatively low within 240min of total furnace time. With the first and third pass phosphorus removal equipment turned on, the incidence of defects was relatively low.
To explore whether different polyvinylpyrrolidone (PVP) concentrations affect the results of intracytoplasmic sperm injection (ICSI), a prospective study was conducted for 194 couples undergoing 210 ICSI therapy cycles. These cycles were divided into three groups (10, 7 and 5% groups) using the corresponding concentration of PVP for sperm immobilization. The main outcome measures were analyzed. Results indicated that, with a decrease in PVP concentrations, all of the main outcome measures increased. In particular, the high-quality cleavage embryo rate in the 7% group was significantly lower than in the 5% group (P < 0.01), and the cleavage, high-quality cleavage embryo, and high-quality blastocyst rates in the 5% group were significantly higher than those in the 10% group (all P < 0.001). For high-/intermediate-quality semen, all of the main outcome measures were significantly increased with 5% PVP. For the poor-quality semen, only the high-quality cleavage embryo and high-quality blastocyst rates were significantly higher in the 5% group. Therefore, lowering PVP concentrations greatly promoted the development of embryos in ICSI cycles, with an optimal concentration of 5% for ICSI.
Novel NiMoO4-integrated electrode materials were successfully prepared by solvothermal method using Na2MoO4·2H2O and NiSO4·6H2O as main raw materials, water, and ethanol as solvents. The morphology, phase, and structure of the as-prepared materials were characterized by SEM, XRD, Raman, and FT-IR. The electrochemical properties of the materials in supercapacitors were investigated by cyclic voltammetry, constant current charge–discharge, and electrochemical impedance spectroscopy techniques. The effects of volume ratio of water to ethanol (W/E) in solvent on the properties of the product were studied. The results show that the pure phase monoclinic crystal NiMoO4 product can be obtained when the W/E is 2:1. The diameter and length are 0.1–0.3 µm and approximately 3 µm, respectively. As an active material for supercapacitor, the NiMoO4 nanorods material delivered a discharge specific capacitance of 672, 498, and 396 F/g at a current density of 4, 7, and 10 A/g, respectively. The discharge specific capacitance slightly decreased from 815 to 588 F/g with a retention of 72% after 1000 cycles at a current density of 1 A/g. With these superior capacitance properties, the novel NiMoO4 integrated electrode materials could be considered as promising material for supercapacitors.
Co-receptor tropism has been identified to correlate with HIV-1 transmission and the disease progression in patients. A molecular epidemiology investigation of co-receptor tropism is important for clinical practice and effective control of HIV-1. In this study, we investigated the co-receptor tropism on HIV-1 variants of 85 antiretroviral-naive patients with Geno2pheno algorithm at a false-positive rate of 10%. Our data showed that a majority of the subjects harboured the CCR5-tropic virus (81.2%, 69/85). No significant differences in gender, age, baseline CD4+ T-cell counts and transmission routes were observed between subjects infected with CXCR4-tropic or CCR5-tropic virus. The co-receptor tropism appeared to be associated with the virus genotype; a significantly more CXCR4-use was predicted in CRF01_AE infections whereas all CRF07_BC and CRF08_BC were predicted to use CCR5 co-receptor. Sequences analysis of V3 revealed a higher median net charge in the CXCR4 viruses over CCR5 viruses (4.0 vs. 3.0, P < 0.05). The predicted N-linked glycosylation site between amino acids 6 and 8 in the V3 region was conserved in CCR5 viruses, but not in CXCR4 viruses. Besides, variable crown motifs were observed in both CCR5 and CXCR4 viruses, of which the most prevalent motif GPGQ existed in both viral tropism and almost all genotypes identified in this study except subtype B. These findings may offer important implications for clinical practice and enhance our understanding of HIV-1 biology.
CrFeNiTix (x = 0.2, 0.3, 0.4, 0.5, and 0.6 molar ratio) compositionally complex alloys were fabricated by vacuum arc melting to investigate the microstructure, hardness, and compressive properties. The results revealed that CrFeNiTix alloys consisted of the principal face-centered cubic (FCC) phase and body-centered cubic (BCC) solid solution, with an amount of (Ni, Ti)-rich hexagonal close-packed phase. CrFeNiTix alloys exhibited the typical dendrite. Ti0.2 and Ti0.3 alloys were composed of FCC and BCC solid solutions in the dendrite, as well as ε (Ni3Ti) and R (Ni2.67Ti1.33) phases in the inter-dendrite, simultaneously. For Ti0.4, Ti0.5, and Ti0.6 alloys, (Fe, Cr)-rich solid solution separated out and ε phase transformed into R phase gradually. Meanwhile, TEM analysis indicated that Ti0.4 alloy matrix consisted of the principal FCC phase containing (Ni, Ti)-rich intragranular nanoprecipitates. The hardness values of CrFeNiTix alloys were increased with the addition of Ti content and the high compressive strength of CrFeNiTix alloys was maintained, which was attributed to the solid solution strengthening and precipitation hardening.
In this work, we proposed a possible mechanism for the formation S-type planet in close binaries (0.5 au < aB < 3 au). Numerical simulations showed that the maximum capture probability is ∼ 10%, which can be comparable to the tidal capture probability of hot Jupiters in single star systems. The capture probability is related to binary configurations. Furthermore, we find that S-type planets with retrograde orbits can be naturally produced via capture process. These planets on retrograde orbits can help us distinguish in situ formation and post-capture origin for S-type planet in close binaries. The forthcoming missions (PLATO or TESS) will provide the opportunity and feasibility to detect such planets.
To investigate the impact of viral and bacterial co-infection in hospitalised children with Mycoplasma pneumoniae pneumonia (RMPP). Retrospective analysis of 396 children with RMPP in our hospital admitted between 1 January 2011 and 31 December 2016 was performed. Nasal aspirate samples were collected for pathogen detection and clinical data were collected. We analysed clinical characteristics, lung imaging characteristics and pathogenic species among these children. Of the 396 RMPP cases, 107 (27.02%) had co-infection with other pathogen, with Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus being the most common bacteria of infection and human bocavirus (HBoV), human rhinovirus, respiratory syncytial virus being the most common viruses of infection. Children with co-infection were younger than that with single infection (P = 0.010). Children with both virus and bacteria co-infection had been the youngest (P = 0.040). Children with co-infection had a longer fever process, higher leukocyte count, higher C-reactive protein compared with single infection (P < 0.05). Children with co-infection had a higher percentage of pnemothorax and diffuse large area of inflammation in chest X-ray manifestation compared with children with single infection (P < 0.05). S. pneumonia and HBoV was the leading cause of co-infection in RMPP. Co-infections led to more disease severity in children with RMPP compared with single infections.
In this paper, a triple-wideband bandpass filter (BPF) with controllable bandwidths based on two multi-mode stub-loaded resonators (MMSLRs) and a triple-mode resonator is presented. The MMSLR is loaded with two identical folded open-ended stubs and a T-shaped stub. Each passband of the tri-band BPF is formed by four resonant modes, which provide sufficient bandwidths to meet various application requirement. By adjusting the lengths of open-ended stubs, three passband bandwidths can be controlled individually. The center frequencies of the triple-wideband BPF are allocated at 2.7, 3.67, and 5.44 GHz, with the 3 dB fractional bandwidths (FBWs) of 20.1, 14.7, and 26.3%. Among the three passbands, the highest one covers the 5 G WiFi band (5.15–5.85 GHz). The measured results of the proposed filter exhibit excellent agreement with simulated results.
Wave radiation and diffraction by a circular cylinder submerged below an ice sheet with a crack are considered based on the linearized velocity potential theory together with multipole expansion. The solution starts from the potential due to a single source, or the Green function satisfying both the ice sheet condition and the crack condition, as well as all other conditions apart from that on the body surface. This is obtained in an integral form through Fourier transform, in contrast to what has been obtained previously in which the Green function is in the series form based on the method of matched eigenfunction expansion in each domain on both sides of the crack. The multipole expansion is then constructed through direct differentiation of the Green function with respect to the source position, rather than treating each multipole as a separate problem. The use of the Green function enables the problem of wave diffraction by the crack in the absence of the body to be solved directly. For the circular cylinder, wave radiation and diffraction problems are solved by applying the body surface boundary condition to the multipole expansion, through which the unknown coefficients are obtained. Extensive results are provided for the added mass and damping coefficient as well as the exciting force. When the cylinder is away from the crack, a wide spacing approximation method is used, which is found to provide accurate results apart from when the cylinder is quite close to the crack.
Both fibronectin (FN) and filamentous actin (F-actin) fibers play a critical role for endothelial cells (ECs) in responding to shear stress and modulating cell alignment and functions. FN is dynamically coupled to the F-actin cytoskeleton via focal adhesions. However, it is unclear how ECs cooperatively remodel their subcellular FN matrix and intracellular F-actin cytoskeleton in response to shear stress. Current studies are hampered by the lack of a reliable and sensitive quantification method of FN orientation. In this study, we developed a MATLAB-based feature enhancement method to quantify FN and F-actin orientation. The role of F-actin in FN remodeling was also studied by treating ECs with cytochalasin D. We have demonstrated that FN and F-actin codistributed and coaligned parallel to the flow direction, and that F-actin alignment played an essential role in regulating FN alignment in response to shear stress. Our findings offer insight into how ECs cooperatively remodel their subcellular ECM and intracellular F-actin cytoskeleton in response to mechanical stimuli, and are valuable for vascular tissue engineering.
More than 200 molecular clouds were newly found distributed beyond the Outer arm in the extreme outer Galaxy (EOG) region by MWISP. Those MCs roughly following the HI′s distribution well delineate the outermost spiral structure (the Outer Scutum-Centaurus arm) and warp of our Galaxy. Besides, those MCs show different σv-Radius relation and exhibit higher value of αvir than MCs in the inner Galaxy.
In this paper we present new petrological and whole-rock geochemical data for the Palaeoproterozoic metasedimentary rocks in the upper part of the Ji'an Group within the Jiao–Liao–Ji Belt, China, as well as zircon U–Pb age dates and in situ Lu–Hf isotope data. The new data improve our understanding of the original nature of the metasedimentary rocks, further providing insights into their tectonic setting and the evolutionary history of the northern segment of the Jiao–Liao–Ji Belt. The zircons can be divided into two groups, viz., one of magmatic origin and the other of metamorphic origin. Zircon U–Pb dating gave mean or statistical peak ages for the magmatic zircons at 2035, 2082, 2178, 2343–2421, 2451–2545, 2643–2814 and 2923–3446 Ma, and mean peak ages for the metamorphic zircons at 1855 and 1912 Ma, which indicate a maximum depositional age of 2.03 Ga and two-stage metamorphic events at c. 1.91 and 1.85 Ga for the metasedimentary rocks. Geochemical data show that (1) the protoliths of these rocks were mainly sandstones, greywackes and claystones, together with some shales; (2) the main sources of the sedimentary material were Palaeoproterozoic granites and acid volcanic rocks, with minor contributions from Archaean granitic rocks; and (3) the sediments were deposited in an active continental margin setting. Moreover, along the northeastern margin of the Eastern Block of the North China Craton there is evidence of ancient crustal materials as old as 3.76 Ga, and multiple crustal growth events at 3.23–3.05, 2.80–2.65, 2.54–2.45 and 2.28–2.08 Ga.
Because of steady increase in the availability of computing power, ab initio methods of computational materials science become everyday investigation tools in various research fields. This popularity of the first-principle-based atomistic modeling is in large part due to the performance of density functional theory (DFT), which could be used for simulations of chemically and structurally complex materials, including minerals, fluids and melts. However, because of intrinsic approximations, DFT is not always able to deliver reliable predictions. This is especially pronounced for f-elements bearing materials such as nuclear materials considered in nuclear waste management. Properties such as reaction enthalpies or electronic state are often badly predicted. In this contribution we discuss our experience with different computational methods, including the parameter free DFT+U method, in which the Hubbard U parameter is derived ab initio, for prediction of various properties of f electrons bearing materials. We show significant improvement obtained for structural and thermochemical parameters of various lanthanide-bearing ceramic materials and actinide-bearing molecular and solid compounds when the f electrons correlations are explicitly accounted for. Last, but not least, we demonstrate that complementary experimental and atomistic modeling studies result in superior and more complete characterization of challenging materials considered in nuclear waste management.
The present study aims to evaluate the antiparasitic activity of active components from Cynanchum paniculatum against Ichthyophthirius multifiliis. The antiparasitic activities of two bioassay-guided fractionationated compounds from C. paniculatum identified as Cynatratoside-A and Cynanversicoside C, by comparing spectral data (NMR and ESI-MS) with literature values, were evaluated by in vitro assay. These showed that both could kill theronts of I. multifiliis at a concentration of 10·0 mg L−1, with the median effective concentration (EC50) values of 4·6 mg L−1 and 5·2 mg L−1 for Cynatratoside-A and Cynanversicoside C, respectively. Encysted tomonts were killed at concentrations of 8·0 mg L−1 with both compounds. In vivo experiments demonstrated that fish treated with both compounds at 15·0 mg L−1 carried significantly fewer parasites than controls (P < 0·05). There were no mortalities among treated fish group compared with 75% mortality of untreated fish. Cynatratoside-A and Cynanversicoside C are therefore potential candidate drugs for use against I. multifiliis.
Enterotoxigenic Escherichia coli (ETEC) is a type of pathogenic bacteria that cause diarrhea in piglets through colonizing pig small intestine epithelial cells by their surface fimbriae. Different fimbriae type of ETEC including F4, F18, K99 and F41 have been isolated from diarrheal pigs. In this study, we performed a genome-wide association study to map the loci associated with the susceptibility of pigs to ETEC F41 using 39454 single nucleotide polymorphisms (SNPs) in 667 F2 pigs from a White Duroc×Erhualian F2 cross. The most significant SNP (ALGA0022658, P=5.59×10−13) located at 6.95 Mb on chromosome 4. ALGA0022658 was in high linkage disequilibrium (r2>0.5) with surrounding SNPs that span a 1.21 Mb interval. Within this 1.21 Mb region, we investigated ZFAT as a positional candidate gene. We re-sequenced cDNA of ZFAT in four pigs with different susceptibility phenotypes, and identified seven coding variants. We genotyped these seven variants in 287 unrelated pigs from 15 diverse breeds that were measured with ETEC F41 susceptibility phenotype. Five variants showed nominal significant association (P<0.05) with ETEC F41 susceptibility phenotype in International commercial pigs. This study provided refined region associated with susceptibility of pigs to ETEC F41 than that reported previously. Further works are needed to uncover the underlying causal mutation(s).