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Obesity and metabolic syndrome are significant problems for patients
taking antipsychotic drugs. Evidence is emerging of genetic risk
To investigate the influence of two candidate genes, smoking and drug
treatment on obesity and metabolic syndrome in patients with
Patients (n=134) were assessed for measures of obesity, other factors
contributing to metabolic syndrome, and two genetic polymorphisms
(5-HT2C receptor −759C/T and leptin −2548A/G).
Neither genotype nor smoking was significantly associated with measures
of obesity. However, both leptin genotype and smoking were significantly
associated with metabolic syndrome. Significant interaction occurred
between the genetic polymorphisms for effects on obesity, whereby a
genotype combination increased risk. Drug treatment showed significant
effects on measures of obesity and triglyceride concentrations;
risperidone was associated with lower values than olanzapine or
The findings suggest interacting genetic risk factors and smoking
influence development of metabolic syndrome in patients on antipsychotic
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