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A principle that prohibits States from weakening their domestic levels of environmental protection continues to emerge at varying speeds within international trade, investment and environmental law. This article explores the principle's diverse history, rationale and legal expression in each of these domains and finds that its various articulations in different international treaties suffer the same shortfalls and deficiencies. Non-regression clauses may leave the complexities and nuances of implementing environmental protections unaddressed, including identifying and measuring when a regression has occurred and balancing these environmental protections with other legitimate policy and environmental measures. As these clauses are increasingly subject to investor–State and State–State dispute procedures, States expose themselves to heightened liability for changes to their environmental laws, even where those changes might be legitimate and reasonable. The particular emergence of this principle in environmental law offers treaty-makers an opportunity to clarify the rights of States to derogate from otherwise narrowly drafted clauses that require them to maintain their level of environmental protection strictly.
Economic inequalities are increasingly prominent in public debates – from Thomas Piketty’s seminal Capital in the Twenty-First Century (Piketty 2014) and the subsequent creation of the World Inequality Database (Wid.World n.d.), to civil society reports such as that of Oxfam (Oxfam International 2019). In addition, major social movements of the last decade, including Tunisia’s 2011 revolution (Srebernik 2014) and the rise to power of demagogic leaders such as Donald Trump (Shiller 2016), have been attributed, at least in part, to economic inequalities.
Suicidal behaviour is common in acute psychiatric wards resulting in distress, and burden for patients, carers and society. Although psychological therapies for suicidal behaviour are effective in out-patient settings, there is little research on their effectiveness for in-patients who are suicidal.
Aims
Our primary objective was to determine whether cognitive–behavioural suicide prevention therapy (CBSP) was feasible and acceptable, compared with treatment as usual (TAU) for in-patients who are suicidal. Secondary aims were to assess the impact of CBSP on suicidal thinking, behaviours, functioning, quality of life, service use, cost-effectiveness and psychological factors associated with suicide.
Method
A single-blind pilot randomised controlled trial comparing TAU to TAU plus CBSP in in-patients in acute psychiatric wards who are suicidal (the Inpatient Suicide Intervention and Therapy Evaluation (INSITE) trial, trial registration: ISRCTN17890126). The intervention consisted of TAU plus up to 20 CBSP sessions, over 6 months continuing in the community following discharge. Participants were assessed at baseline and at 6 weeks and 6 months post-baseline.
Results
A total of 51 individuals were randomised (27 to TAU, 24 to TAU plus CBSP) of whom 37 were followed up at 6 months (19 in TAU, 18 in TAU plus CBSP). Engagement, attendance, safety and user feedback indicated that the addition of CBSP to TAU for in-patients who are acutely suicidal was feasible and acceptable while on in-patient wards and following discharge. Economic analysis suggests the intervention could be cost-effective.
Discussion
Psychological therapy can be delivered safely to patients who are suicidal although modifications are required for this setting. Findings indicate a larger, definitive trial should be conducted.
Declaration of interest
The trial was hosted by Greater Manchester Mental health NHS Trust (formerly, Manchester Mental Health and Social Care NHS Trust). The authors are affiliated to the University of Manchester, Greater Manchester Mental Health Foundation Trust, Lancashire Care NHS Foundation trust and the Manchester Academic Health Sciences Centre. Y.A. is a trustee for a North-West England branch of the charity Mind.
Surface tension causes the edge of a fluid sheet to retract. If the sheet is also stretched along its edge then the flow and the rate of retraction are modified. A universal similarity solution for the Stokes flow in a stretched edge shows that the scaled shape of the edge is independent of the stretching rate, and that it decays exponentially to its far-field thickness. This solution justifies the use of a stress boundary condition in long-wavelength models of stretched viscous sheets, and gives the detailed shape of the edge of such a sheet, resolving the position of the sheet edge to the order of the thickness.
When two spherical bubbles touch, a hole is formed in the fluid sheet between them, and capillary pressure acting on its tightly curved edge drives an outward radial flow which widens the hole joining the bubbles. Recent images of the early stages of this process (Paulsen et al., Nat. Commun., vol. 5, 2014) show that the radius of the hole $r_{\!E}$ at time $t$ grows proportional to $t^{1/2}$, and that the rate is dependent on the fluid viscosity. Here, we explain this behaviour in terms of similarity solutions to a third-order system of radial extensional-flow equations for the thickness and velocity of the sheet of fluid between the bubbles, and determine the growth rate as a function of the Ohnesorge number $\mathit{Oh}$. The initially quadratic sheet profile allows the ratio of viscous and inertial effects to be independent of time. We show that the sheet is slender for $r_{\!E}\ll a$ if $\mathit{Oh}\gg 1$, where $a$ is the bubble radius, but only slender for $r_{\!E}\ll \mathit{Oh}^{2}a$ if $\mathit{Oh}\ll 1$ due to a compressional boundary layer of length $L\propto \mathit{Oh}\,r_{\!E}$, after which there is a change in the structure but not the speed of the retracting sheet. For $\mathit{Oh}\ll 1$, the detailed analysis justifies a simple momentum-balance argument, which gives the analytic prediction $r_{\!E}\sim (32a{\it\gamma}/3{\it\rho})^{1/4}t^{1/2}$, where ${\it\gamma}$ is the surface tension and ${\it\rho}$ is the density.
Approximately 25% of people with bulimia nervosa (BN) who undertake therapy are treated in groups. National guidelines do not discriminate between group and individual therapy, yet each has potential advantages and disadvantages and it is unclear how their effects compare. We therefore evaluated how group therapy for BN compares with individual therapy, no treatment, or other therapies, in terms of remission from binges and binge frequency.
Method
We performed a systematic review and meta-analysis of randomized controlled trials of group therapies for BN, following standard guidelines.
Results
A total of 10 studies were included. Studies were generally small with unclear risk of bias. There was low-quality evidence of a clinically relevant advantage for group cognitive behavioural therapy (CBT) over no treatment at therapy end. Remission was more likely with group CBT versus no treatment [relative risk (RR) 0.77, 95% confidence interval (CI) 0.62–0.96]. Mean weekly binges were lower with group CBT versus no treatment (2.9 v. 6.9, standardized mean difference = −0.56, 95% CI −0.96 to −0.15). One study provided low-quality evidence that group CBT was inferior compared with individual CBT to a clinically relevant degree for remission at therapy end (RR 1.24, 95% CI 1.03–1.50); there was insufficient evidence regarding frequency of binges.
Conclusions
Conclusions could only be reached for CBT. Low-quality evidence suggests that group CBT is effective compared with no treatment, but there was insufficient or very limited evidence about how group and individual CBT compared. The risk of bias and imprecise estimates of effect invite further research to refine and increase confidence in these findings.
The evolutionary history of human malaria parasites (genus Plasmodium) has long been a subject of speculation and controversy. The complete genome sequences of the two most widespread human malaria parasites, P. falciparum and P. vivax, and of the monkey parasite P. knowlesi are now available, together with the draft genomes of the chimpanzee parasite P. reichenowi, three rodent parasites, P. yoelii yoelli, P. berghei and P. chabaudi chabaudi, and one avian parasite, P. gallinaceum.
Methods
We present here an analysis of 45 orthologous gene sequences across the eight species that resolves the relationships of major Plasmodium lineages, and provides the first comprehensive dating of the age of those groups.
Results
Our analyses support the hypothesis that the last common ancestor of P. falciparum and the chimpanzee parasite P. reichenowi occurred around the time of the human-chimpanzee divergence. P. falciparum infections of African apes are most likely derived from humans and not the other way around. On the other hand, P. vivax, split from the monkey parasite P. knowlesi in the much more distant past, during the time that encompasses the separation of the Great Apes and Old World Monkeys.
Conclusion
The results support an ancient association between malaria parasites and their primate hosts, including humans.
A 65 m vertical shaft was sunk at Dounreay in the 1950s to build a tunnel for the offshore discharge of radioactive effluent from the various nuclear facilities then under construction. In 1959, the Shaft was licensed as a disposal facility for radioactive wastes and was routinely used for the disposal of ILW until 1970. Despite the operation of a hydraulic containment scheme, some radioactivity is known to have leaked into the surrounding rocks. Detailed logging, together with mineralogical and radiochemical analysis of drillcore has revealed four distinct bedding-parallel zones of contamination. The data show that Sr-90 dominates the bulk beta/gamma contamination signal, whereas Cs-137 and Pu-248/249 are found only to be weakly mobile, leading to very low activities and distinct clustering around the Shaft. The data also suggest that all uranium seen in the geosphere is natural in origin. At the smaller scale, contamination adjacent to fracture surfaces is present within a zone of enhanced porosity created by the dissolution of carbonate cements from the Caithness flagstones during long-term rockwater interactions. Quantitative modelling of radionuclide migration, using the multiphysics computer code QPAC shows the importance of different sorption mechanisms and different mineralogical substrates in the Caithnesss flagstones in controlling radionuclide migration.
This study examined the English vowel productions of 240 native speakers of Italian who had arrived in Canada at ages ranging from 2 to 23 years and 24 native English speakers from the same community. The productions of 11 vowels were rated for degree of foreign accent by 10 listeners. An increase in perceived accentedness as a function of increasing age of arrival was observed on every vowel. Not one of the vowels was observed to be produced in a consistently native-like manner by the latest-arriving learners, even though they had been living in Canada for an average of 32 years. However, high intelligibility (percent correct identification) scores were obtained for the same set of productions. This was true even for English vowels that have no counterpart in Italian.
Preliminary investigations of a new high-strength alloy of composition Fe30Ni20Mn25Al25 (at.%) are described in this paper. The as-cast alloy consisted of a periodic two-phase microstructure of interconnected, ∼50-nm-wide rods with fully coherent {100} interfaces, strongly suggestive of formation by a B2 to [(B2 + body-centered cubic (bcc)] spinodal decomposition. The (Ni,Al)-rich B2 and (Fe,Mn)-rich bcc phases differed in lattice parameter by <0.5%. Hardness and yield strength of the as-cast alloy were found to be approximately 500 VPN and 1500 MPa, respectively, and increased by more than 50% after annealing at 550 °C for several days. (Fe,Mn)-rich precipitates with a β–Mn structure were observed in the annealed material.
Neuropsychologists often diagnose cerebral dysfunction based, in part, on marked variation in an individual's cognitive test performance. However, little is known about what constitutes the normal range of intraindividual variation. In this study, after excluding 54 individuals with significant health problems, we derived 32 z-transformed scores from 15 tests administered to 197 adult participants in a study of normal aging. The difference between each person's highest and lowest scores was computed to assess his or her maximum discrepancy (MD). The resulting MD values ranged from 1.6 to 6.1 meaning that the smallest MD shown by any person was 1.6 standard deviations (SDs) and the largest MD shown by any person was 6.1 SDs. Sixty-six percent of participants produced MD values that exceeded 3 SDs. Eliminating each person's highest and lowest test scores decreased their MDs, but 27% of the participants still produced MD values exceeding 3. Although MD values appeared to increase with age, adjusting test scores for age, which is standard in clinical practice, did not correct for this. These data reveal that marked intraindividual variability is very common in normal adults, and underscore the need to base diagnostic inferences on clinically recognizable patterns rather than psychometric variability alone. (JINS, 2003, 9, 864–870.)
The purpose of this study, which focused on the word taco as spoken in Spanish and English, was to explore the word as a unit in second language (L2) speech acquisition. As expected, acoustic measurements revealed that Spanish and English monolinguals' renditions of taco differed systematically. It was also shown that the extent to which Spanish/English bilinguals approximated English phonetic norms for any one segment of taco was correlated with their approximation for the other three segments, and that early learners differentiated Spanish versus English taco more than did late learners. It also appeared that the bilinguals produced /t/ with less English-like voice onset time (VOT) values in English taco than in other English words without a cognate in Spanish. In a perception experiment, listeners were able to identify the native language of Spanish and English monolinguals on the basis of their production of taco. The listeners heard larger differences between Spanish and English taco tokens spoken by early than late learners of English L2. Two additional perception experiments assessed further the phonetic dimensions that listeners use to determine language identity and to gauge bilinguals' speech production accuracy. Listeners assigned to language identification and goodness rating tasks responded to acoustic information distributed over all four segments in taco, although the VOT of the word-initial /t/ appeared to be the single most important phonetic dimension. Taken together, the results of this study suggest that (a) bilinguals' accuracy in producing the various segments of a second language word may be interrelated and (b) in judging L2 speech, listeners respond to phonetic errors distributed over the entire word.
In July 1913, while collecting the larvæ of the large Pine Weevil (Hylobius abietis), I discovered a number of tiny larvæ feeding on some of them. These I succeeded in rearing, and they proved to be the larvæ of a Bracon which seemed to be B. hylobii. In July 1914 I recorded my experiments and observations.* In this record I stated that my identification of the species was based on Ratzeburg's description.† All the specimens I examined—and I have examined many—agree, for the most part, with his description of B. hylobii. In April 1914, specimens were sent for determination to Dr Szeplegeti, the authority for the family, in Budapest, but so far no reply has been received.
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