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And it came to pass, that after three days they found him in the temple, sitting in the midst of the doctors, both hearing them, and asking them questions.
And all that heard him were astonished at his understanding and answers…
And he said unto them, How is it that ye sought me? wist ye not that I must be about my Father's business;
(Luke ii. 46-47, 49)In September 1511 Robert de Keyzere published five poems written by Erasmus in honor of the new school ‘quern nuper instituit Coletus’ and of its ‘president’, the Boy Jesus. These poems, which are usually grouped together under the title Carmina scholaria, were evidently intended to be sung as hymns by the boys of St. Paul's; they are still so classified in the 1896 edition of Preces hymni et catechismus Graece et Latine in usum antiquae et Celebris Scholae S. Pauli, etc.
A healthy, balanced diet is essential for both physical and mental well-being. Such a diet must include an adequate intake of micronutrients, essential fatty acids, amino acids and antioxidants. The monoamine neurotransmitters, serotonin, dopamine and noradrenaline, are derived from dietary amino acids and are involved in the modulation of mood, anxiety, cognition, sleep regulation and appetite. The capacity of nutritional interventions to elevate brain monoamine concentrations and, as a consequence, with the potential for mood enhancement, has not been extensively evaluated. The present study investigated an extract from oregano leaves, with a specified range of active constituents, identified via an unbiased, high-throughput screening programme. The oregano extract was demonstrated to inhibit the reuptake and degradation of the monoamine neurotransmitters in a dose-dependent manner, and microdialysis experiments in rats revealed an elevation of extracellular serotonin levels in the brain. Furthermore, following administration of oregano extract, behavioural responses were observed in mice that parallel the beneficial effects exhibited by monoamine-enhancing compounds when used in human subjects. In conclusion, these data show that an extract prepared from leaves of oregano, a major constituent of the Mediterranean diet, is brain-active, with moderate triple reuptake inhibitory activity, and exhibits positive behavioural effects in animal models. We postulate that such an extract may be effective in enhancing mental well-being in humans.
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