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1 results

  • Estimation of microsatellite mutation rates in Drosophila melanogaster
  • JOSÉ FERNANDO VÁZQUEZ, TRINIDAD PÉREZ, JESÚS ALBORNOZ, ANA DOMÍNGUEZ
  • Journal: Genetics Research / Volume 76 / Issue 3 / December 2000
  • Published online by Cambridge University Press: 18 January 2001, pp. 323-326
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    Microsatellite mutations were studied in a set of 175 mutation accumulation lines, all of them independently derived from a completely homozygous population of Drosophila melanogaster and maintained under strong inbreeding during 80 generations. We assayed 28 microsatellites and detected two mutations. One mutation consisted of a single addition of a dinucleotide repeat and the other was a deletion of five trinucleotide repeats. The average mutation rate was 5·1 × 10−6, in full agreement with previous estimates from two different sets of mutation accumulation lines.