A new cementitious calcium phosphate biomaterial, SuperBone®, was implanted in both a rabbit femoral canal model and a canine humeral plug model. New Zealand White rabbits were implanted with cement through a novel surgical approach where cement was introduced by injection. In the canine model, a uniform gap of 3 mm around a fiber metal porous implant was filled by the cement. Undecalcified light and backscattered electron histological evaluations indicate the cement is highly biocompatible and is replaced by new bone in concert with cell-mediated resorption. Unlike the acrylic bone cement positive controls, no evidence of fibrous tissue was found around the cement.