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The giant gypsum crystals of Naica cave have fascinated scientists since their discovery in 2000. Human activity has changed the microclimate inside the cave, making scientists wonder about the potential environmental impact on the crystals. Over the last 9 years, we have studied approximately 70 samples. This paper reports on the detailed chemical–structural characterization of the impurities present at the surface of these crystals and the experimental simulations of their potential deterioration patterns. Selected samples were studied by petrography, optical and electronic microscopy, and laboratory X-ray diffraction. 2D grazing incidence X-ray diffraction, X-ray μ-fluorescence, and X-ray μ-absorption near-edge structure were used to identify the impurities and their associated phases. These impurities were deposited during the latest stage of the gypsum crystal formation and have afterward evolved with the natural high humidity. The simulations of the behavior of the crystals in microclimatic chambers produced crystal dissolution by 1–4% weight fraction under high CO2 concentration and permanent fog, and gypsum phase dehydration under air and CO2 gaseous environment. Our work suggests that most surface impurities are of natural origin; the most significant anthropogenic damage on the crystals is the extraction of water from the caves.
Ekbom's syndrome or delusional parasitosis (DP), is an “uncommon psychiatric syndrome” characterized by the presence of delusion of infestation.
The syndrome may be seen in association wiht a number of neuropsychiatric conditions, including bipolar disorder, paranoia,schizophrenia, dementia, depression as well as abuse of drugs, such as cocaine or amphetamines. Previously, DP was often considered to be a monosymptomatic hypochondraical psychosis. Delusions of parasitosis has also been reported in association with a number of medical conditions that are characterized by itching.
Objective
To review the literature through a case report.
Case report
A 52 year-old female, unmarried who lives alone, was admitted for parasitosis delusions that had started in the last two months. She complained of vermins crawling through her skin, mainly on her face and scalp. The illness began with pricking and itching sensations on her head. She used to put the “little animals” in a piece of paper to prove their existence. Risperodone was started up to 3 mg per day. She had a progressive clinical improvement and in one week was discharged.
Conclusions
In conclusion, rather than a unique illness, DP is a neuropsychiatric syndrome that can follow primary psychotic and depressive disorders, dementia or other organic diseases. The typical patient is an elderly woman who is unmarried or living along.
There have been no double-blind studies confirming that atypical antipsychotics are more effective than pimozide in the treatment of DP. Further trials are warranted to study the true efficacy of atypical antipsychotics in the treatment of DP.
Suicidal behaviour in children and adolescents is a matter of great concern and suicide-related behaviour during psychopharmacological treatment has been analyzed during the last years. Medication-related suicidality is defined as any suicide-related symptoms reported during the period of treatment. Suicide-related symptoms have several components that need to be considered to study suicide risk and its relationship with medication. The components have been classified and named in different ways, but the main are: Suicide ideation (thoughts about death, wish to be death), Suicide plans (to think about methods of carrying out a self-injurious behaviour that can result in death), Suicide communication or threats (to transmit or comment thoughts or intention of suicide, either explicit or implicit), Suicide behaviours of self-harm or suicide attempts (self-inflicted, dangerous behaviour with intention to die with nonfatal outcome). Self-injurious behaviour without suicidal ideation is not included in the concept of suicide-related symptoms by many authors, but it is also necessary to register it in order to have a complete picture and also because the intentionality behind these behaviours is not always clear. All of these concepts can be of different level considering real intention to die, determination of plans and severity of self inflicted injuries. Other important aspects to assess suicide risk are the moderating and mediating variables. The evaluation of suicide-related symptoms and association to medications has to be carried out with a validated instrument that assess all these components and their relation to different drug side-effects, prior treatment starts and subsequently during control visits.
The Square Kilometre Array (SKA) is a planned large radio interferometer designed to operate over a wide range of frequencies, and with an order of magnitude greater sensitivity and survey speed than any current radio telescope. The SKA will address many important topics in astronomy, ranging from planet formation to distant galaxies. However, in this work, we consider the perspective of the SKA as a facility for studying physics. We review four areas in which the SKA is expected to make major contributions to our understanding of fundamental physics: cosmic dawn and reionisation; gravity and gravitational radiation; cosmology and dark energy; and dark matter and astroparticle physics. These discussions demonstrate that the SKA will be a spectacular physics machine, which will provide many new breakthroughs and novel insights on matter, energy, and spacetime.
Here, different tissue surfaces of tomato root were characterized employing atomic force microscopy on day 7 and day 21 of growth through Young's modulus and plasticity index. These parameters provide quantitative information regarding the mechanical behavior of the tomato root under fresh conditions in different locations of the cross-section of root [cell surface of the epidermis, parenchyma (Pa), and vascular bundles (Vb)]. The results show that the mechanical parameters depend on the indented region, tissue type, and growth time. Thereby, the stiffness increases in the cell surface of epidermal tissue with increasing growth time (from 9.19 ± 0.68 to 13.90 ± 1.68 MPa) and the cell surface of Pa tissue displays the opposite behavior (from 1.74 ± 0.49 to 0.48 ± 0.55); the stiffness of cell surfaces of Vb tissue changes from 10.60 ± 0.58 to 6.37 ± 0.53 MPa, all cases showed a statistical difference (p < 0.05). Viscoelastic behavior dominates the mechanical forces in the tomato root. The current study is a contribution to a better understanding of the cell mechanics behavior of different tomato root tissues during growth.
The MUSE TIMER Survey has obtained high signal and high spatial resolution integral-field spectroscopy data of the inner ~ 6×6 kpc of 21 nearby massive disc galaxies. This allows studies of the stellar kinematics of the central regions of massive disc galaxies that are unprecedented in spatial resolution. We confirm previous predictions from numerical and hydrodynamical simulations of the effects of bars and inner bars on stellar and gaseous kinematics, and also identify box/peanuts via kinematical signatures in mildly and moderately inclined galaxies, including a box/peanut in a face-on inner bar. In 20/21 galaxies we find inner discs and show that their properties are fully consistent with the bar-driven secular evolution picture for their formation. In addition, we show that these inner discs have, in the region where they dominate, larger rotational support than the main galaxy disc, and discuss how their stellar population properties can be used to estimate when in cosmic history the main bar formed. Our results are compared with photometric studies in the context of the nature of galaxy bulges and we show that inner discs are identified in image decompositions as photometric bulges with exponential profiles (i.e., Sérsic indices near unity).
The question whether stellar bars are either transitory features or long-lived structures is still matter of debate. This problem is more acute for double-barred systems where even the formation of the inner bar remains a challenge for numerical studies. We present a thorough study of the central structures of the double-barred galaxy NGC 1291. We used a two-dimensional multi-component photometric decomposition performed on the 3.6 μm images from S4 G, combined with both stellar kinematics and stellar population analysis carried out using integral field data from the MUSE TIMER project. We report on the discovery of the first Box-Peanut (B/P) structure in an inner bar detected in the face-on galaxy NGC 1291. The B/P structure is detected as bi-symmetric minima of the h4 moment of the line-of-sight velocity distribution along the major axis of the inner bar, as expected from numerical simulations. Our observations demonstrate that inner bars (similarly as outer bars) can suffer buckling instabilities, thus suggesting they can survive a long time after bar formation. The analysis of the star formation history for the structural components shaping the central regions of NGC 1291 also constrains the epoch of dynamical assembly of the inner bar, which took place >6.5 Gyr ago for NGC 1291. Our results imply that the inner bar of NGC 1291 is a long-lived structure.
We introduce the Galaxy IFU Spectroscopy Tool (GIST), a convenient, all-in-one and multi-purpose tool for the analysis and visualisation of already reduced (integral-field) spectroscopic data. In particular, the pipeline performs all steps from read-in and preparation of data to its scientific analysis and visualisation in publication-quality plots. The code measures stellar kinematics and non-parametric star formation histories using the pPXF routine (Cappellari & Emsellem 2004; Cappellari 2017), performs an emission-line analysis with the GandALF procedure (Sarzi et al. 2006; Falcón-Barroso et al. 2006), and determines absorption line-strength indices and their corresponding single stellar population equivalent population properties (Kuntschner et al.2006; Martín-Navarro et al. 2018). The dedicated visualisation routine Mapviewer facilitates the access of all data products in a sophisticated graphical user interface with fully interactive plots.
Data-driven decompositions are becoming essential tools in fluid dynamics, allowing for tracking the evolution of coherent patterns in large datasets, and for constructing low-order models of complex phenomena. In this work, we analyse the main limits of two popular decompositions, namely the proper orthogonal decomposition (POD) and the dynamic mode decomposition (DMD), and we propose a novel decomposition which allows for enhanced feature detection capabilities. This novel decomposition is referred to as multi-scale proper orthogonal decomposition (mPOD) and combines multi-resolution analysis (MRA) with a standard POD. Using MRA, the mPOD splits the correlation matrix into the contribution of different scales, retaining non-overlapping portions of the correlation spectra; using the standard POD, the mPOD extracts the optimal basis from each scale. After introducing a matrix factorization framework for data-driven decompositions, the MRA is formulated via one- and two-dimensional filter banks for the dataset and the correlation matrix respectively. The validation of the mPOD, and a comparison with the discrete Fourier transform (DFT), DMD and POD are provided in three test cases. These include a synthetic test case, a numerical simulation of a nonlinear advection–diffusion problem and an experimental dataset obtained by the time-resolved particle image velocimetry (TR-PIV) of an impinging gas jet. For each of these examples, the decompositions are compared in terms of convergence, feature detection capabilities and time–frequency localization.
The Centro de Laseres Pulsados in Salamanca, Spain has recently started operation phase and the first user access period on the 6 J 30 fs 200 TW system (VEGA 2) already started at the beginning of 2018. In this paper we report on two commissioning experiments recently performed on the VEGA 2 system in preparation for the user campaign. VEGA 2 system has been tested in different configurations depending on the focusing optics and targets used. One configuration (long focal length
$F=130$
cm) is for underdense laser–matter interaction where VEGA 2 is focused onto a low density gas-jet generating electron beams (via laser wake field acceleration mechanism) with maximum energy up to 500 MeV and an X-ray betatron source with a 10 keV critical energy. A second configuration (short focal length
$F=40$
cm) is for overdense laser–matter interaction where VEGA 2 is focused onto a
$5~\unicode[STIX]{x03BC}\text{m}$
thick Al target generating a proton beam with a maximum energy of 10 MeV and temperature of 2.5 MeV. In this paper we present preliminary experimental results.
This paper addresses the chemical synthesis and characterization of a composite formed by Li2O-Al2O3-Al3Fe-Al3Fe5O12/PCL which were obtained by the process of reduction of ferric chloride (FeCl3) with lithium aluminum hydride (LiAlH4) in an open atmosphere. The goal of the development of this hybrid material was to perform a superparamagnetic material with several potential applications. The results of the characterizations by scanning electron microscopy (SEM) and vibrating sample magnetometer showed a Li2O-Al2O3-Al3Fe-Al3Fe5O12 “desert rose stone”-like morphology 3D hierarchical powders formation when particles were sintered at 850 °C. Homogeneous nanometric particles after calcination at 1100 °C were observed. X-ray diffraction analysis were performed to determine their composition. Subsequently, the superparamagnetic powders were added by dispersion in a polycaprolactone (PCL) matrix, and then, were evaluated by SEM for the observation of their morphologies. The composite material presented a polymer network with an opened structure, a well dispersion of the oxides particles into the interstices with irregular topography and reliefs.
Laser-based compact MeV X-ray sources are useful for a variety of applications such as radiography and active interrogation of nuclear materials. MeV X rays are typically generated by impinging the intense laser onto ~mm-thick high-Z foil. Here, we have characterized such a MeV X-ray source from 120 TW (80 J, 650 fs) laser interaction with a 1 mm-thick tantalum foil. Our measurements show X-ray temperature of 2.5 MeV, flux of 3 × 1012 photons/sr/shot, beam divergence of ~0.1 sr, conversion efficiency of ~1%, that is, ~1 J of MeV X rays out of 80 J incident laser, and source size of 80 m. Our measurement also shows that MeV X-ray yield and temperature is largely insensitive to nanosecond laser contrasts up to 10−5. Also, preliminary measurements of similar MeV X-ray source using a double-foil scheme, where the laser-driven hot electrons from a thin foil undergoing relativistic transparency impinging onto a second high-Z converter foil separated by 50–400 m, show MeV X-ray yield more than an order of magnitude lower compared with the single-foil results.
The dispersion coefficient of a passive solute in a steady-state pure electro-osmotic flow (EOF) of a viscoelastic liquid, whose rheological behaviour follows the simplified Phan-Thien–Tanner (sPTT) model, along a parallel flat plate microchannel, is studied. The walls of the microchannel are assumed to have modulated and low
$\unicode[STIX]{x1D701}$
potentials, which vary slowly in the axial direction in a sinusoidal manner. The flow field required to obtain the dispersion coefficient was solved using the lubrication approximation theory (LAT). The solution of the electric potential is based on the Debye–Hückel approximation for a symmetric
$(z:z)$
electrolyte. The viscoelasticity of the fluid is observed to notably amplify the axial distribution of the effective dispersion coefficients due to the variation in the
$\unicode[STIX]{x1D701}$
potentials of the walls. The problem was formulated for two cases: when the Debye layer thickness (EDL) was on the order of unity (thick EDL) and in the limit where the thickness of the EDL was very small compared with the height of the microchannel (thin EDL limit). Due to the coupling between the nonlinear governing equations and the sPTT fluid model, they were replaced by their approximate linearized forms and solved in the limit of
$\unicode[STIX]{x1D700}\ll 1$
using the regular perturbation technique. Here
$\unicode[STIX]{x1D700}$
is the amplitude of the sinusoidal function of the
$\unicode[STIX]{x1D701}$
potentials. Additionally, the numerical solution of the simplified governing equations was also obtained for
$\unicode[STIX]{x1D700}=O(1)$
and compared with the approximate solution, showing excellent agreement for
$0\leqslant \unicode[STIX]{x1D700}\leqslant 0.3$
. Note that the dispersion coefficient primarily depends on the Deborah number, on the ratio of the half-height of the microchannel to the Debye length, and on the assumed variation in the
$\unicode[STIX]{x1D701}$
potentials of the walls.
We undertook observations with the Green Bank Telescope, simultaneously with the 300 m telescope in Arecibo, as a follow-up of a possible flare of radio emission from Ross 128. We report here the non-detections from the GBT observations in C band (4–8 GHz), as well as non-detections in archival data at L band (1.1–1.9 GHz). We suggest that a likely scenario is that the emission comes from one or more satellites passing through the same region of the sky.
Suckling lamb meat is traditionally produced in Mediterranean Europe. Breed can affect the quality of the lamb carcass and meat. This study is aimed at comparing the carcass and meat quality between suckling lambs from a local and a non-native dairy breed, Churra and Assaf. Churra is included in the Spanish Protected Geographical Indication (PGI) ‘Lechazo de Castilla y León’, whereas Assaf is not. However, Assaf breeders have requested the inclusion of the breed in the PGI. Carcasses and meat from 16 male lambs (eight Churra and eight Assaf) were used in this study. The lambs were all raised under an intensive rearing system and fed on a milk substitute to minimise maternal influence. The carcasses were evaluated for conformation, fatness, joint and leg tissue proportions and the meat was analysed for composition (i.e. proximate composition, iron, haematin, fatty acids and volatiles) and technological quality traits (i.e. texture, water holding capacity, colour and lipid stability). Churra carcasses were larger than Assaf carcasses. However, the proportions of commercial joints and main tissues did not differ between breeds. Cavity and intermuscular leg fat, but not total leg fat, were higher in Churra carcasses. Churra meat showed a higher proportion of n-6 fatty acids, higher redness and better colour stability during aerobic storage. In contrast, Assaf lamb was more resistant to lipid oxidation after cooking. This is a preliminary study to measure the influence of breed on a wide range of quality characteristics in Churra and Assaf suckling lamb carcass and meat. It may be of relevance for breeders, consumers and food policy makers, setting the basis for future studies that include larger commercial populations.
Contact precautions are a traditional strategy to prevent transmission of methicillin-resistant Staphylococcus aureus (MRSA). Chlorhexidine bathing is increasingly used to decrease MRSA burden and transmission in intensive care units (ICUs). We sought to evaluate a hospital policy change from routine contact precautions for MRSA compared with universal chlorhexidine bathing, without contact precautions. We measured new MRSA acquisition in ICU patients and surveyed for MRSA environmental contamination in common areas and non-MRSA patient rooms before and after the policy change. During the baseline and chlorhexidine bathing periods, the number of patients (453 vs. 417), ICU days (1999 vs. 1703) and MRSA days/1000 ICU days (109 vs. 102) were similar. MRSA acquisition (2/453 vs. 2/457, P = 0·93) and environmental MRSA contamination (9/474 vs. 7/500, P = 0·53) were not significantly different between time periods. There were 58% fewer contact precaution days in the ICU during the chlorhexidine period (241/1993 vs. 102/1730, P < 0·01). We found no evidence that discontinuation of contact precautions for patients with MRSA in conjunction with adoption of daily chlorhexidine bathing in ICUs is associated with increased MRSA acquisition among ICU patients or increased MRSA contamination of ICU fomites. Although underpowered, our findings suggest this strategy, which has the potential to reduce costs and improve patient safety, should be assessed in similar but larger studies.
A new species of Laeonereis from a shrimp farm associated with a subtropical coastal lagoon on the Mexican Pacific coast is described. The new species is characterized by a deep anterior groove on the prostomium, which is shared only with L. culveri. However, longer tentacular cirri extending back to the anterior margin of chaetiger two, the number of papillae of each group on the maxillary ring of the pharynx, and the relative size of the homogomph falcigers in the new species, allow us to separate the two species. Although the species has not been previously detected in the coastal lagoon surrounding the shrimp farm, we postulate that L. watsoni n. sp. is likely to be part of the invertebrate communities of the upper parts of similar coastal lagoons that are common along the tropical coasts of Mexico.
Recent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology.
Aims
To systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD).
Method
Analysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD (n = 93), childhood ADHD (n = 17), MDD (n = 63), ASD (n = 51), childhood dual diagnosis of ADHD–ASD (n = 16) and healthy controls (n = 78).
Results
Weighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures.
Conclusions
Our results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors.
Clinical research studies of behavioral variant frontotemporal dementia (bvFTD) often use Alzheimer disease (AD) as a comparison group for control of dementia variables, using tests of cognitive function to match the groups. These two dementia syndromes, however, are very different in clinical manifestations, and the comparable severity of these dementias may not be reflected by commonly used cognitive scales such as the Mini-Mental State Examination (MMSE).
Methods:
We evaluated different measures of dementia severity and symptoms among 20 people with bvFTD compared to 24 with early-onset AD.
Results:
Despite similar ages, disease-duration, education, and cognitive performance on two tests of cognitive function, the MMSE and the Montreal Cognitive Assessment (MoCA), the bvFTD participants, compared to the AD participants, were significantly more impaired on other measures of disease severity, including function (Functional Assessment Questionnaire (FAQ)), neuropsychiatric symptoms (Neuropsychiatric Inventory (NPI)), and global dementia stage (Clinical Dementia Rating Scales (CDRs)). However, when we adjusted for the frontotemporal lobar degeneration-CDR (FTLD-CDR) in the analyses, the two dementia groups were comparable across all measures despite significant differences on the cognitive scales.
Conclusion:
We found tests of cognitive functions (MMSE and MoCA) to be insufficient measures for ensuring comparability between bvFTD and AD groups. In clinical studies, the FTLD-CDR, which includes additional language and behavior items, may be a better overall way to match bvFTD and AD groups on dementia severity.