For most producers, unmanned aerial vehicles (UAV) are a novelty that has been little employed in their agricultural operations. An UAV will not fix every problem on the farm, but there are some practical applications for which UAVs have demonstrated value. Three examples of how UAVs have been used in weed science applications are presented here; the methods are transferable to other agricultural commodities with similar characteristics. The first of these is quantification of the extent and severity of non-target herbicide injury. The second application is calculation of spray thresholds based on weed populations. The third application is development of site-specific herbicide treatment.