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Personality (according to Cloninger) responds to Biological aspects (temperamental) and Psychosocial (characterological), thereby forming the complex pattern of human behavior. High level of avoidance of harm and stiffness are factors associated with depressive disorders, closely linked to the Serotoninergic System. Melancholicus Typus (MT) is characterizes by its seriousness, scrupulousness of conscience, perfectionism, responsibility and order at all levels among other features.
Develop an inventory psychometrically to assess the influence of personality traits Melancholicus Typus in the appearance of resistant depression throughout life.
Retrospective observational study. We designed a questionnaire with a total of 70 items that shaped the personality of Melancholicus Typus. We explored the internal consistency using statistical factor analysis, as well as discriminate validity of these. This questionnaire was applied to the sample of 100 patients signed informed consent prior. They met criteria for inclusion/exclusion. The patient population is from the Institute of Psychiatry Rafael Coullaut. Madrid.
The existence of personality traits of Melancholicus Typus identifies a vulnerability to developing relevant resistant depression over the life of individuals. The inventory developed for this study is a useful test to assess personality traits such as Melancholicus Typus both clinical populations and general population.
The scale shows good construct validity, as well as good internal consistency through correlations Item/Total. The reliability of the scale is high.
To evaluate the efficacy, safety, and tolerability of fixed-dose agomelatine 25 and 50 mg/d in the treatment of outpatients with obsesive-compulsive disorder (OCD) compared to placebo.
In this 8-week, multicenter, double-blind, parallel-group trial, patients with DSM-IV-defined OCD were randomly assigned (1:1:1) to receive a once-daily dose of agomelatine 25 mg, agomelatine 50 mg, or placebo. The primary efficacy measure was the change from baseline to week 8 in the clinician-rated 17-item Hamilton Depression Rating Scale (HDRS(17)); other efficacy measures were The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Clinical Global Impression scale. The study was conducted between December 2009 and January 2010.
Agomelatine 25 mg/d was more efficacious based on the HDRS(17) total score (P = .01) compared to placebo throughout the treatment period, whereas for agomelatine 50 mg/d, statistically significant reduction in HDRS(17) total score could be observed from weeks 2 to 6 but not at week 8 (P = .144). A higher proportion of patients receiving agomelatine 25 mg/d showed clinical response (P = .013), clinical remission (P = .07), and improvement according to the Clinical Global Impressions-Improvement scale (P = .065) compared to those receiving placebo. No statistically significant difference between patients receiving agomelatine 50 mg/d compared to placebo on clinical response. Both agomelatine doses were safe and well tolerated, although clinically notable aminotransferase elevations were observed transiently in the agomelatine 50 mg/d group.
Agomelatine 50 mg/d provided evidence for its antidepressant efficacy until week 6 and was also safe and well tolerated.
1 Determine the prevalence of cognitive impairment in the population to study.
2 Determine treatment antidemential more prescribed in the population to study.
3 Determine the drugs more associated with the treatment antidemential.
4 Determine what is the pathology psychiatric more associated with cognitive impairment.
5 Determine the profile patient with cognitive impairment.
A retrospective and observational study. Sample size of 2628 patients. The criterions for inclusion were: persons admitted to the HCUV in 2006–2010, assisted by the service of liaison psychiatry hospitalized and that gave the informed consent. Was carried out valuation neuropsychological (MMS and CDR). Diagnostic as DSM-IV-TR.
The prevalence of cognitive impairment was 15.2%.
The specialties that most requested the service of psychiatry at link were: internal medicine: 31.6%; Traumatology: 11.9%; 83.6% had been hospitalized for somatic reasons 9,6% for psychiatric reasons. The most common psychiatric pathology was Delirium 32.9%; Adaptive Disorder 30.7%, Cognitive Impairment 15.2%. Out of the 15.2% of patients with dementia, 85% receives specific treatment with at least a drug antidemential. The most used was Citicoline85,3%. In 71% observed concomitantly neuropsychiatric symptoms:
Agitation(63,2%), anxiety(6,7%). The main associated treatments were Tiapride(70,1%) and Quetiapina and (21,9%).
The prevalence of cognitive impairment in patients of liaison psychiatry hospitalized in the HCUV is high, 15%. The frequency grows up with age increases as well as the related medical pathology. In the specific treatment have been used mainly:
Donepezilo, Rivastigmine  Memantine. The evolution of the patients was favorable in 88,9%.
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