This study explores accessibility to public transport facilities and participation in work life experienced by persons with physical and cognitive impairments. Participants were 21 persons with mobility (n = 6), neuropsychiatric (n = 6), hearing (n = 7), or visual impairments (n = 2) (males = 11, females = 10; age range = 16 to 79). Data were collected using focus group discussions and thematically analysed. The findings point to significant physical, social/attitudinal and communication limitations to the access of public transportation and participation in work life. While participants with physical impairments emphasised lack of accessibility in terms of transport accommodations, persons with neuropsychiatric impairments focused on the social and interactional aspects of public transport. Work life participation was mostly impacted by lack of flexibility in work tasks and work organisation, and fear of being misunderstood and perceived as incapable.