Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

9 results

  • Informant-Reported Cognitive Decline is Associated with Objective Cognitive Performance in Parkinson’s Disease

  • Marina Z. Nakhla, Kelsey A. Holiday, J. Vincent Filoteo, Zvinka Z. Zlatar, Vanessa L. Malcarne, Stephanie Lessig, Irene Litvan, Dawn M. Schiehser
  • Journal: Journal of the International Neuropsychological Society / Volume 27 / Issue 5 / May 2021
  • Published online by Cambridge University Press: 09 December 2020, pp. 439-449
  • Objective:

    The utility of informant-based measures of cognitive decline to accurately describe objective cognitive performance in Parkinson’s disease (PD) without dementia is uncertain. Due to the clinical relevance of this information, the purpose of this study was to examine the relationship between informant-based reports of patient cognitive decline via the Informant Questionnaire of Cognitive Decline in the Elderly (IQCODE) and objective cognition in non-demented PD controlling for cognitive status (i.e., mild cognitive impairment; PD-MCI and normal cognition; PD-NC).

    Method:

    One-hundred and thirty-nine non-demented PD participants (PD-MCI n = 38; PD-NC n = 101) were administered measures of language, executive function, attention, learning, delayed recall, visuospatial function, mood, and motor function. Each participant identified an informant to complete the IQCODE and a mood questionnaire.

    Results:

    Greater levels of informant-based responses of patient cognitive decline on the IQCODE were significantly associated with worse objective performance on measures of global cognition, attention, learning, delayed recall, and executive function in the overall sample, above and beyond covariates and cognitive status. However, the IQCODE was not significantly associated with language or visuospatial function.

    Conclusions:

    Results indicate that informant responses, as measured by the IQCODE, may provide adequate information on a wide range of cognitive abilities in non-demented PD, including those with MCI and normal cognition. Findings have important clinical implications for the utility of the IQCODE in the identification of PD patients in need of further evaluation, monitoring, and treatment.

  • Selective Deficits in Alzheimer and Parkinsonian Dementia: Visuospatial Function

  • Erich Mohr, Irene Litvan, Jill Williams, Paul Fedio, Thomas N. Chase
  • Journal: Canadian Journal of Neurological Sciences / Volume 17 / Issue 3 / August 1990
  • Published online by Cambridge University Press: 18 September 2015, pp. 292-297
    • Article
      • You have access
    • PDF
    • Export citation

  • Deficits in visuospatial cognition are frequently cited as an important component of the cognitive changes accompanying Parkinson's disease. To characterize possible differences between Parkinson's (PD) and Alzheimer's (AD) dementia, patients from both groups, matched for overall dementia severity, age and education, were contrasted neuropsychologically. Visuospatial tasks dissociated from memory, were significantly compromised in both patient groups. Differential impairment was evident on visuospatial abstraction and reasoning (Object Assembly), which was most deficient in PD. Visuospatial cognition associated with memory, classified both patient groups as impaired compared to controls, but AD patients demonstrated substantially lower performance levels than those with PD. Parkinsonian dementia thus appears to have some distinct features compared to Alzheimer's disease, which may indicate differences in underlying pathogenic mechanisms.

  • Case 31 - Woman with gait impairment and difficulty reading

  • Edited by Serge Gauthier, McGill University, Montréal, Pedro Rosa-Neto, McGill University, Montréal
  • Book: Case Studies in Dementia
  • Published online: 16 May 2011
  • Print publication: 21 April 2011, pp 229-237

  • Summary

    This chapter presents the case of a 57-year-old right-handed man with a 1-year history of poor balance, increasing forgetfulness, and difficulties following conversations. There is a family history of malignancy in two first-degree relatives. Neurological examination reveals saccadic pursuit eye movements but no nystagmus, impaired fine finger movements, depressed ankle jerks, and impaired vibration and temperature sensation in both distal lower limbs. HIV associated neurocognitive disorder (HAND) varies in severity from the asymptomatically neurocognitively impaired to those with dementia. Risk factors for the development of HIV dementia (HAD) include: persistently high viral load, low nadir CD4 cell count, increasing age and female sex, low body mass index, anaemia, and intravenous drug abuse. HAND varies in severity from the asymptomatically neurocognitively impaired to those with dementia. The CNS damage underlying HAND occurs secondarily to the direct toxic action of virus-produced proteins and as a consequence of immune activation.