In the present paper we provide an account of VSO in Greek and its (relative) absence in Italian, despite the fact that both languages allow for postverbal subjects. We argue that this parametric difference reduces to different lexicalisation options regarding the D-system of the two grammars. We assume that the clause structure divides into three basic domains (V, T, and C), and that nominal (clitic) positions are available in each of these domains, which, as we argue, can be lexicalised not only by clitics but also by full DPs. On this basis, we argue that the subject and object DP in Greek can appear in the same domain (V), as they spell out different features depending on their grammatical function, while this is not so in Italian, given that DPs spell out the same set of features irrespective of their grammatical function. This basic difference is responsible for the presence of VSO in Greek but not in Italian. We also consider the implications of our approach for the interpretation of subjects and arguments in general.