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Resting state functional magnetic resonance imaging studies have identified functional connectivity patterns associated with acute undernutrition in anorexia nervosa (AN), but few have investigated recovered patients. Thus, a trait connectivity profile characteristic of the disorder remains elusive. Using state-of-the-art graph–theoretic methods in acute AN, the authors previously found abnormal global brain network architecture, possibly driven by local network alterations. To disentangle trait from starvation effects, the present study examines network organization in recovered patients.
Graph–theoretic metrics were used to assess resting-state network properties in a large sample of female patients recovered from AN (recAN, n = 55) compared with pairwise age-matched healthy controls (HC, n = 55).
Indicative of an altered global network structure, recAN showed increased assortativity and reduced global clustering as well as small-worldness compared with HC, while no group differences at an intermediate or local network level were evident. However, using support-vector classifier on local metrics, recAN and HC could be separated with an accuracy of 70.4%.
This pattern of results suggests that long-term recovered patients have an aberrant global brain network configuration, similar to acutely underweight patients. While the finding of increased assortativity may represent a trait marker of AN, the remaining findings could be seen as a scar following prolonged undernutrition.
Annually dated tree-rings of 509 live and deadwood limber pine (Pinus flexilis) samples from the semi-arid Wassuk Range, Nevada, yielded a 3996-yr record extending from 1983 BC to AD 2013. Correlations of radial growth with climate were positive for water relations and negative for summer temperatures. Long-term trends of ring-width corresponded to climate variability documented from other proxies, including low growth during the Late Holocene Dry Period and Medieval Climate Anomaly (MCA) and elevated growth during cool, wet periods of the Neoglacial and Little Ice Age. Spline fit of the data indicated that growth decrease in the last 20 years was second lowest on record, surpassed by lowest growth at 20 BC—AD 150. Demographics of limber pine by aspect and elevation were not strongly related to long-term climate dynamics, except in the case of extirpations on all but north aspects at the end of the MCA. Pines occurred persistently on north aspects, where a continuous record existed to present. Elevation shifts were not obvious on any aspect, and no evidence existed for migration above current treeline. Non-climatic factors appear to interact with climate to make north slopes refugial for upland pines in semi-arid regions across four millennia.
We present first results from a coordinated multiwavelength study of the neutron star low-mass X-ray binary EXO 0748 676. Fast UV, X-ray, and optical data were obtained including both spectral and timing information. We discuss how this study allows us to probe the temperature distribution within the binary and hence the geometry and efficiency of X-ray irradiation.
The scientific advances that underpin economic growth and human health would not be possible without research investments. Yet demonstrating the impact of research programs is a challenge, especially in areas that span disciplines, industrial sectors, and encompass both public and private sector activity. All areas of research are under pressure to demonstrate benefits from federal funding of research. This exciting and innovative study demonstrates new methods and tools to trace the impact of federal research funding on the structure of research, and the subsequent economic activities of funded researchers. The case study is food safety research, which is critical to avoiding outbreaks of disease. The authors make use of an extraordinary new data infrastructure and apply new techniques in text analysis. Focusing on the impact of US federal food safety research, this book develops vital data-intensive methodologies that have a real world application to many other scientific fields.
Previous studies have highlighted the role of the brain reward and cognitive control systems in the etiology of anorexia nervosa (AN). In an attempt to disentangle the relative contribution of these systems to the disorder, we used functional magnetic resonance imaging (fMRI) to investigate hemodynamic responses to reward-related stimuli presented both subliminally and supraliminally in acutely underweight AN patients and age-matched healthy controls (HC).
fMRI data were collected from a total of 35 AN patients and 35 HC, while they passively viewed subliminally and supraliminally presented streams of food, positive social, and neutral stimuli. Activation patterns of the group×stimulation condition×stimulus type interaction were interrogated to investigate potential group differences in processing different stimulus types under the two stimulation conditions. Moreover, changes in functional connectivity were investigated using generalized psychophysiological interaction analysis.
AN patients showed a generally increased response to supraliminally presented stimuli in the inferior frontal junction (IFJ), but no alterations within the reward system. Increased activation during supraliminal stimulation with food stimuli was observed in the AN group in visual regions including superior occipital gyrus and the fusiform gyrus/parahippocampal gyrus. No group difference was found with respect to the subliminal stimulation condition and functional connectivity.
Increased IFJ activation in AN during supraliminal stimulation may indicate hyperactive cognitive control, which resonates with clinical presentation of excessive self-control in AN patients. Increased activation to food stimuli in visual regions may be interpreted in light of an attentional food bias in AN.
We performed a spatial-temporal analysis to assess household risk factors for Ebola virus disease (Ebola) in a remote, severely-affected village. We defined a household as a family's shared living space and a case-household as a household with at least one resident who became a suspect, probable, or confirmed Ebola case from 1 August 2014 to 10 October 2014. We used Geographic Information System (GIS) software to calculate inter-household distances, performed space-time cluster analyses, and developed Generalized Estimating Equations (GEE). Village X consisted of 64 households; 42% of households became case-households over the observation period. Two significant space-time clusters occurred among households in the village; temporal effects outweighed spatial effects. GEE demonstrated that the odds of becoming a case-household increased by 4·0% for each additional person per household (P < 0·02) and 2·6% per day (P < 0·07). An increasing number of persons per household, and to a lesser extent, the passage of time after onset of the outbreak were risk factors for household Ebola acquisition, emphasizing the importance of prompt public health interventions that prioritize the most populated households. Using GIS with GEE can reveal complex spatial-temporal risk factors, which can inform prioritization of response activities in future outbreaks.
We report the preliminary results of a CCD surface photometry survey of a large fraction of all known Galactic globular clusters. About 1/5 of all surveyed clusters show a characteristic post-core-collapse (PCC) morphology. The PCC clusters are on average closer to the Galactic center than the King-model-like clusters.
Radio-interferometric tracking of the Global Positioning System (GPS) satellites offers a new technique for regular monitoring of variations in the earth's rotation. The observations are sensitive to pole position and length-of-day, at a level of precision which may make this technique competitive with satellite and lunar laser ranging and very long baseline interferometry (VLBI). The present limitations are the number of satellites and tracking stations available and inadequate modeling of non-gravitational forces on the satellites. The potential advantages are rapid turn-around and minimal incremental cost. We have performed a preliminary analysis using six days of observations from a four-station network. Comparison of earth rotation values from our GPS analysis with values obtained by VLBI and laser ranging reveals differences after five days of 0.9 ms in UT1, 0.04″ in x and 0.07″ in y. These differences reflect errors in the GPS determinations due primarily to inadequate modeling of non-gravitational forces.
The accumulation of drifting snow around buildings in regions of severe climate has important implications on their design and location. This paper studies one such building, at a station run by the British Antarctic Survey and located on the Brunt Ice Shelf at the edge of the Antarctic continent. Four previous stations have been built in the area, the buildings of which were designed to become covered in snow and all have been crushed within a few years. The current station, Halley V, consists of three buildings which are all raised from the ice shelf by means of legs. They were designed in such a way that the action of the wind blowing underneath the buildings would keep them-clear of snow.
This paper describes a model which predicts the shape and position of drift formation, and then compares the results with those observed at Halley. This model is a first attempt to address the problem and as such the paper can be considered to be a progress report; improvements arc currently being made as part of continuing research. It is found that there is some qualitative agreement and possible reasons for a few quantitative discrepancies are discussed. Both the model and the true data show clearly that the new design is very effective in prolonging the useful life of the buildings.
We report the discovery of a new double image gravitational lens system B1030+074 which was found during the Jodrell Bank - VLA Astrometric Survey (JVAS). We have collected extensive radio data on the system using the VLA, MERLIN, the EVN and the VLBA as well as HST WFPC2 and NICMOS observations. The lensed images are separated by 1.56 arcseconds and their flux density ratio at centimetric wavelengths is approximately 14:1 although the ratio is slightly frequency dependent and the images appear to be time variable. The HST pictures show both the lensed images and the lensing galaxy close to the weaker image. The lensing galaxy has substructure which could be either part of the galaxy or a companion object. We have modeled B1030+074 using a Singular Isothermal Ellipsoid that yielded a time delay of 156/h50 days. This lens is likely to be suitable for the measurement of the Hubble constant.