The Zr65Al7.5Ni10Cu17.5 bulk metallic glasses were prepared by injection casting (casting temperature of 1100 °C) and in situ suction casting (casting temperature as high as 3000 °C). The strain-rate-dependent mechanical behaviors of the specimens were investigated under axial compression at room temperature over a wide strain rate range (1.6 × 10−5–1.6 × 10−1 s−1). The specimens prepared by injection casting exhibited negative strain rate sensitivity, i.e., the yield stress decreased with increasing strain rate. In contrast, no strain rate sensitivity was observed for the specimens prepared by in situ suction casting. The different strain rate sensitivities in the specimens prepared at different temperatures were probably caused by the diversities of the local atomic structures.