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This is an essential guide to the data, basic science, outcome studies and decision-making processes involved in blood and marrow stem cell transplantation. Organized according to disease types and procedures, it contains more than 100 tables, figures and algorithms that reflect up-to-date research and give guidance on the choices between different types of chemotherapy, autologous vs. allogeneic transplantation, peripheral blood vs. bone marrow stem cells, and standard vs. experimental treatments. This new edition summarizes the research of the last four years and gives mature data for all established indications, such as acute myeloid leukemia, myelodysplastic syndrome and Hodgkin and non-Hodgkin lymphomas. New chapters discuss global trends in stem cell transplantation, cellular therapies including donor lymphocytes, and pediatric neurologic and metabolic disorders. With an expanded complications section, links to electronic databases and discussion of new drugs and alternative stem cell sources, this text belongs in every transplant unit.
The last 15 years have seen a major change, expansion, and improvement in the discipline of clinical bone marrow and blood stem cell transplantation. Unifying bone marrow and peripheral blood stem cell transplants, the term hematopoietic cell transplantation has been proposed. New data have become available to support the decision for or against transplantation. The future has started already. Basic science has made progress: new genes and microRNAs have been characterized as risk factors in the outcomes of hematologic malignancies. The involvement of natural killer cells in the graft-versus-tumor reactions has been recognized. New cell populations like dendritic cells and mesenchymal stem cells have been characterized. Clinical science has made progress. New indications for transplants have been developed and evaluated. Examples are renal cell cancer, autoimmune disorders, and amyloidosis. New stem cell sources (e.g., from cord blood) were implemented. Owing to sophisticated typing methods, unrelated transplants have become safer. Because of increased donor numbers, matched unrelated transplants can now be offered to more than 70% of patients who do not have a family match. Old indications (breast cancer) have become obsolete or are being reevaluated (chronic myelogenous leukemia) because of advances in the nontransplant arena. In the first edition of this book, transplant for multiple myeloma was put into context against “conventional” treatments. Now, autologous transplant has become the standard of care for multiple myeloma, which has to compete and will join forces with antiangiogenic agents or proteasome inhibitors. New treatment protocols for older patients or those who have significant comorbidities were introduced (reduced-intensity conditioning).
Center for International Blood and Marrow Transplantation Research (formerly known as International Bone Marrow Transplant Registry)
International database on autologous and allogeneic BMT/SCT performs outcomes research and publishes a newsletter with outcomes data and posttransplant guidelines.
Partnership of National Marrow Donor Program and International Bone Marrow and Autologous Blood and Marrow Transplant Registry of Medical College of Wisconsin. Promotes studies to increase safety and success of transplant and improve access to healthcare services.
National Marrow Donor Program
Information about the activities of the National Marrow Donor Program (NMDP) facilitating matched unrelated transplantation. This information is directed to potential donors, patients, and physicians. The NMDP maintains the world’s largest volunteer donor database and performs accreditation of transplant centers and outcomes research.