To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Both cognitive and behavioral problems are common in people with epilepsy. State-dependent cognitive impairment is potentially reversible and treatable. People having frequent absence seizures may present as having withdrawn behavior, fragmented thought processes which may be mistaken for a psychosis, attention-deficit disorder with motor over activity, or, if the frequency of the seizures is variable, attention seeking behavior. It is important to be aware of the possibility of reversible, state-dependent cognitive impairment in an individual who is in a constant postictal state from frequent seizures. Reducing the seizure frequency can improve cognitive function markedly. It has become evident that a number of children who present with markedly autistic features have unsuspected epileptiform discharges either during the day or at night. If frequent epileptiform discharges are found in association with cognitive or behavioral problems then early, energetic treatment should be initiated.
Patients with refractory temporal lobe epilepsy (TLE) are at higher risk for mental and cognitive impairments than healthy controls (Hermann et al., 1987, 1997; Trimble, 1988). Typically patients with right-sided TLE are frequently impaired in visuo-spatial retention tasks; patients with left-sided TLE may exhibit deficits of verbal memory. Because of these frequent and prominent memory deficits it is sometimes neglected that many TLE patients perform below healthy control subjects on a variety of neuropsychological tests including intelligence measures (Hermann et al., 1997). The probable reason is that the temporal epileptogenic zone is not only malfunctioning but also adversely influences remote cerebral structures resulting in additional cognitive deficits (Engel et al., 1991; Lüders and Awad, 1991). One of our recent studies confirmed that assumption (Jokeit et al., 1997).
We investigated 96 TLE patients by FDG-PET and neuropsychological assessment who had a corresponding unilateral temporal hypometabolism, left hemisphere speech dominance, full scale IQ of >70 and no extra-temporal lesion on MRIs. The regional glucose metabolism was determined in each patient in homologous regions including prefrontal cortex. A multivariate analysis of variance revealed that the observed prefrontal metabolic disturbances, that are remote from the temporal epileptogenic zone, were associated with impaired intellectual abilities. Patients who demonstrated prefrontal metabolic disturbances performed worse on verbal as well as performance IQ measures than patients without prefrontal metabolic disturbances. Although patients who demonstrated prefrontal metabolic disturbances had an earlier epilepsy onset, the revealed association with cognitive impairment was unrelated to the age at onset.
Email your librarian or administrator to recommend adding this to your organisation's collection.