Excavations at La Sufricaya, a minor ritual group in the outskirts of the Lowland Maya city of Holmul, have documented two mural paintings inside an elite building of Early Classic date (A.D. 300–A.D. 600). One of the paintings is mythological in nature (Mural 9). The second bears an inscription with references to calendrical and historical events. It commemorates a notorious arrival date at Tikal on 11 Eb 15 Mak (January 16, A.D. 378) on its first anniversary. The architecture and artifacts associated with the murals combine Maya and Teotihuacan decorative motifs, and offer several parallels with Tikal assemblages. The iconography, epigraphy, and archaeological associations of these murals are discussed in relation to the function of the palace complex. This important new evidence contributes to an understanding of which role relations with Teotihuacan may have played in regional politics in the Maya Lowlands during the Early Classic period from the point of view of a smaller site. The interpretations presented here focus on the concept of political intervention of Tikal in the affairs of secondary and tertiary sites.