The increasingly intelligent, highly complex, technical systems of tomorrow - for instance autonomous vehicles - result in the necessity for a systematic security- and safety-oriented development process that starts in the early phases of system design. Automotive Systems Engineering (ASE) as one approach is increasingly gaining ground in the automotive industry. However, this approach is still in a prototype stage. The consideration of security and safety within the early stages of systems design leads to so- called ill-defined problems. Such are not covered by ASE, but can be addressed by means of Design Thinking. Therefore we introduce an approach to combine both approaches. Based on this combination, we derive potentials in the context of the consideration of security and safety. Essential advantages are the possibility to think ahead of threat scenarios at an early stage in system design. Due to an incomplete database, this is not supported or only partially supported by conventional approaches. The resulting potentials are derived based upon a practical example.