Intensive agriculture has the objective to increase nutrients use efficiency. Nitrogen (N) is a key nutrient for crops and the estimations of crop N status allow adjusting the fertilization levels to crop requirements, while reducing the environmental costs and optimizing the benefits for farmers. In this work the N status of wheat in a commercial plot has been monitored, varying the N supply taking into account the variability of the soil. The N content in the cover has been monitored simultaneously by sampling at field level and by using vegetation indices based on reflectance in the red-edge band. The results of the field campaign along a crop growth cycle show that the REP, MTCI, AIVI and CCCI calculated from narrow spectral bands show good linear correlations (R2>0.93) with respect to N content (g·m−2). These indices are stable when passing to broad bands as the case of Sentinel 2 with R2>0.9.