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Lack of trust toward medical research is a major barrier to research participation, particularly among some population groups. Valid measures of trust are needed to develop appropriate interventions. The study purpose was to compare two previously validated scales that measure trust in biomedical research – one developed by Hall et al. (H-TBR; 2006) and the other by Mainous et al. (M-TBR; 2006) – in relation to socio-demographic variables and attitudes toward research. Differences between Black and White respondents were explored.
Two nearly identical surveys – one with H-TBR and the other with M-TBR – were systematically administered to a convenience sample. Internal consistency reliability of each scale was assessed. Associations were computed between scores on each scale with attitudes toward biomedical research and demographic variables (i.e., gender, age, race, and socioeconomic status). The difference between White and Black respondents on each TBR score while controlling for age, education, and race was also investigated.
A total of 2020 participants completed the H-TBR survey; 1957 completed the M-TBR survey. Mean item scores for M-TBR were higher (F = 56.05, p < 0.001) among Whites than Blacks. Whites also had higher mean item scores than Blacks on H-TBR (F = 7.09, p < 0.001). Both scales showed a strong association with participants’ perceived barriers to research (ps < 0.001) and significant, positive correlations with interest in research participation (ps < 0.001). Age and household income were positive predictors of TBR scores, but the effects of education differed.
Both scales are internally consistent and show associations with attitudes toward research. Whites score higher than Blacks on both TBR scales, even while controlling for age and socioeconomic status.
Community engagement is considered essential to effectively translate research into practice and is increasingly recognized as a key to successful clinical trial recruitment. Challenges to engaging community stakeholders in research persist and new methods are needed to facilitate meaningful stakeholder involvement. The Community Engagement Studio (CE Studio), a consultative model, has been used at every stage of the research process. Best practices drawn from the model could inform other methods of engagement. Using a mixed-methods approach that included evaluation surveys, impact surveys and interviews, we assessed the CE Studio program. We analyzed data from 75 CE Studios; 65 researchers and 591 community members completed surveys and 10 researchers completed interviews. Surveys indicate that 100% of researchers would request a CE Studio in the future, and 99.3% of community members would participate in a CE Studio again. We identified 6 practices to enhance community engagement in clinical and translational research: early input, researcher coaching, researcher humility, balancing power, neutral facilitator, and preparation of community stakeholders. These best practices may enhance the quality of existing community engagement approaches and improve the effectiveness of translational researchers’ efforts to engage community stakeholders in their work.
Direct polycondensation of L-lactic acid with a comonomer allows tailoring the properties of the product from the very first step. The viscous L-lactic acid co-oligomers with star-shaped architectures obtained were modified with three different acrylate monomers. Regardless the functionalization agent, UV curing was fast and all materials were cell compatible and promoted cell adhesion. The physical properties of the three star-shaped films exhibited a consistent trend as swelling capacity, hydrolytic instability, and gel content decreased simultaneously. A higher network density increased crosslinking degree and gel content among the films with an isocyanate group. The methacrylic end group functionalized material, lowest molecular weight, consistently exhibited the higher hydrolytic instability. Comparison of physical properties of these films with the corresponding linear materials reported previously confirmed the influence of precursor molecular architecture on the final material. The methodology developed herein is prone to scale-up and lead to the industrial production of new bioadhesives.
Objectives: The aim of this study was to identify whether the three main primary progressive aphasia (PPA) variants would show differential profiles on measures of visuospatial cognition. We hypothesized that the logopenic variant would have the most difficulty across tasks requiring visuospatial and visual memory abilities. Methods: PPA patients (n=156), diagnosed using current criteria, and controls were tested on a battery of tests tapping different aspects of visuospatial cognition. We compared the groups on an overall visuospatial factor; construction, immediate recall, delayed recall, and executive functioning composites; and on individual tests. Cross-sectional and longitudinal comparisons were made, adjusted for disease severity, age, and education. Results: The logopenic variant had significantly lower scores on the visuospatial factor and the most impaired scores on all composites. The nonfluent variant had significant difficulty on all visuospatial composites except the delayed recall, which differentiated them from the logopenic variant. In contrast, the semantic variants performed poorly only on delayed recall of visual information. The logopenic and nonfluent variants showed decline in figure copying performance over time, whereas in the semantic variant, this skill was remarkably preserved. Conclusions: This extensive examination of performance on visuospatial tasks in the PPA variants solidifies some previous findings, for example, delayed recall of visual stimuli adds value in differential diagnosis between logopenic variant PPA and nonfluent variant PPA variants, and illuminates the possibility of common mechanisms that underlie both linguistic and non-linguistic deficits in the variants. Furthermore, this is the first study that has investigated visuospatial functioning over time in the PPA variants. (JINS, 2018, 24, 259–268)
We present an analysis of high signal-to-noise ratio, 430-MHz total intensity single pulse observations from PSR 2303+30 recorded at the Arecibo Observatory in August 1986. We believe that the regular subpulse modulation observed in this pulsar can be explained only in terras of subpulse-associated emission beams rotating around the axis of the pulsar beam. This idea was first introduced by Ruderman and Sutherland (1975) in their spark model. We use the quantitative prediction of this model to calculate the pulsar magnetic field. For this reason we need to estimate the rotation period of a spark around the magnetic pole. We estimate this period by reproducing the observed pulse sequences within an angular beaming model of subpulse emission and fitting this model to the data.
The improvement in porcine embryo preservation and non-surgical embryo transfer (ET) procedures achieved in recent years represents essential progress for the practical use of ET in the pig industry. This study aimed to evaluate the effects of parity, weaning-to-estrus interval (WEI) and season on reproductive and embryonic parameters at day 6 after insemination of donor sows superovulated after weaning. The selection of donor sows was based on their reproductive history, body condition and parity. The effects of parity at weaning (2 to 3, 4 to 5 or 6 to 7 litters), season (fall, winter and spring), and WEI (estrus within 3 to 4 days), and their interactions on the number of corpus luteum, cysts in sows with cysts, number and quality of viable and transferable embryos, embryo developmental stage and recovery and fertilization rates were evaluated using linear mixed effects models. The analyses showed a lack of significant effects of parity, season, WEI or their interactions on any of the reproductive and embryonic parameters examined. In conclusion, these results demonstrate that fertilization rates and numbers of viable and transferable embryos collected at day 6 of the cycle from superovulated donor sows are not affected by their parity, regardless of the time of the year (from fall to spring) and WEI (3 or 4 days).
The intensity of annual Spanish influenza activity is currently estimated from historical data of the Spanish Influenza Sentinel Surveillance System (SISSS) using qualitative indicators from the European Influenza Surveillance Network. However, these indicators are subjective, based on qualitative comparison with historical data of influenza-like illness rates. This pilot study assesses the implementation of Moving Epidemic Method (MEM) intensity levels during the 2014–2015 influenza season within the 17 sentinel networks covered by SISSS, comparing them to historically reported indicators. Intensity levels reported and those obtained with MEM at the epidemic peak of the influenza wave, and at national and regional levels did not show statistical difference (P = 0·74, Wilcoxon signed-rank test), suggesting that the implementation of MEM would have limited disrupting effects on the dynamic of notification within the surveillance system. MEM allows objective influenza surveillance monitoring and standardization of criteria for comparing the intensity of influenza epidemics in regions in Spain. Following this pilot study, MEM has been adopted to harmonize the reporting of intensity levels of influenza activity in Spain, starting in the 2015–2016 season.
“Salvaging an astrometric treasure” is an european effort to retrieve the astrometric and photometric information contained in the early Carte du Ciel plates. Five institutes from three european countries are involved. The project was supported by the European Community.
Due to their low masses dwarf galaxies experience low star-formation rates resulting in stellar cluster masses insufficient to fill the initial mass function (IMF) to the uppermost mass. Numerical simulations usually do not account for the completeness of the IMF, but treat a filed IMF by numbers, masses, and stellar feedback by fractions. To ensure that only entire stars are formed, we consider an IMF filled from the lower-mass regime and truncated where at least one entire massive star is formed.
By 3D simulations we investigate the effects of two possible IMFs on the evolution of dwarf galaxies: filled vs. truncated IMF. For the truncated IMF the star-formation self-regulation is suppressed, while the energy release by typeII supernovae is larger, both compared to the filled IMF. Moreover, the abundance ratios of particular elements yielded from massive and intermediate-mass stars differ significantly between the two IMF distributions.
Current data broadly support trends of galaxy surface brightness profile amplitude and shape with total stellar mass predicted by state-of-the-art ΛCDM cosmological simulations, although recent results show signs of interesting discrepancies, particularly for galaxies less massive than the Milky Way. Here I discuss how perhaps the largest contribution to such discrepancies can be inferred almost directly from how well a given model agrees with the observed present-day galaxy stellar mass function.
Molecular gas has still only been detected beyond the R25 radius in a few galaxies. Is this due to the low H2 content or to the difficulty of using Carbon Monoxide (CO) to trace H2? Similarly, star formation (SF) decreases sharply in the outer disks of spirals although HI is often plentiful; is the decrease in SF because there is little H2 or because the SF is very inefficient in the outer disk environment?
Existing observations suggest that while outer disk clouds tend to be smaller (steeper mass function), their CO brightness temperature is only slightly lower than in the inner disk, at least when observed with sufficiently high angular resolution. In near-solar metallicity galaxies (Z ⩾ 0.5Zsol), the CO does not become intrinsically difficult to detect when H2 is present, even in the outer disk. While more observations of CO or other means of tracing H2 in the outer disks are necessary, current data tend to show that the SF rate per unit H2 remains approximately constant with galactocentric distance, indicating that the star formation proceeds normally but the transformation of HI into H2 is very slow in the outer disk.
Understanding stellar birth requires observations of the clouds in which they form. These clouds are dense and self-gravitating, and in all existing observations, they are molecular with H2 the dominant species and CO the best available. When the abundances of carbon and oxygen are low compared to hydrogen, and the opacity from dust is also low, as in primeval galaxies and local dwarf irregular galaxies CO forms slowly and is easily destroyed, so it cannot accumulate inside dense clouds. Then we lose our ability to trace the gas in regions of star formation and we lose critical information on the temperatures, densities, and velocities of the material that collapses. I will report on high resolution observations with ALMA of CO clouds in the local group dwarf irregular galaxy WLM, which has a metallicity that is 13% of the solar value and 50% lower than the previous CO detection threshold and the properties derived of very small dense CO clouds mapped..
Disk galaxies in cosmological numerical simulations grow by accreting gas from the cosmic web. This gas reaches the external disk, and then spirals in dragged along by tidal forces and/or disk instabilities. The importance of gas infall is as clear from numerical simulations as it is obscure to observations. Extremely metal poor (XMP) galaxies seem to be the best example we have of the gas accretion process at work. They have large off-center starbursts which show significant metallicity drop compared with the host galaxy. This observation is naturally explained as a gas accretion event caught in the act. We present preliminary results of the kinematical properties of the metal poor starbursts in XMPs, which suggest that the starbursts are kinematically decoupled entities within the host galaxy.
The HI in galaxies often extends past their conventionally defined optical extent. I report results from our team which has been probing low intensity star formation in outer disks using imaging in Hα and ultraviolet. Using a sample of hundreds of HI selected galaxies, we confirm that outer disk HII regions and extended UV disks are common. Hence outer disks are not dormant but are dimly forming stars. Although the ultraviolet light in galaxies is more centrally concentrated than the HI, the UV/HI ratio (the Star Formation Efficiency) is nearly constant, with a slight dependency on surface brightness. This result is well accounted for in a model where disks maintain a constant stability parameter Q. This model also accounts for how the ISM and star formation are distributed in the bright parts of galaxies, and how HI appears to trace the distribution of dark matter in galaxy outskirts.
The stellar kinematics of the discs of S0 galaxies (as obtained using planetary nebulae, PNe, and integrated stellar light data) is comparable to that of spiral galaxies, with similar flat rotation curves and falling velocity dispersion profiles, but they present a larger amount of random motions. The only other tracer available to probe the kinematics of individual early-type galaxies are globular clusters (GCs). GCs’ formation is intimately connected to a galaxy major star forming event(s) and GCs are, therefore, good proofs of galaxy formation histories. We directly compare a sample of PNe, GCs, and stellar velocities out to 4 effective radii, in the S0 galaxies NGC 2768 and NGC 1023. In particular, we test a new method for studying GC properties and we find that these two lenticular galaxies are consistent with being formed through different formation mechanisms.
We revisit the well known H i size-mass relation of galaxies with an unprecedented large sample of over 500 galaxies (Wang et al. 2016). We find that the relation and the scatter about the relation do not depend on the galaxy type, optical luminosity or H i richness. It indicates a fundamental unrecognised mechanism that drives the distribution of H i in different galaxies.
We focused on the stellar age-velocity dispersion relation (AVR). We performed the N-body/SPH simulations to investigate the origin of AVR. As a results, we found that AVR is not consistent with simple stellar heating.
In this short write-up, I will concentrate on a few topics of interest. In the 1970s I found very extended HI disks in galaxies such as NGC 5055 and NGC 2841, out to 2 - 2.5 times the Holmberg radius. Since these galaxies are warped, a “tilted ring model” allows rotation curves to be derived, and evidence for dark matter to be found. The evaluation of the amount of dark matter is hampered by a disk-halo degeneracy, which can possibly be broken by observations of velocity dispersions in both the MgI region and the CaII region.
Of the three kinds of neutral gas found outside the stellar disks of Local Group galaxies, only the products of interaction, like the Magellanic Stream, have a clearly understandable origin. Both the high-velocity clouds and the faint H I between M31 and M33 remain a mystery. New observations of the region between M31 and M33 with the Green Bank Telescope show that the H I there resides in clouds with a size and mass similar to that of dwarf galaxies, but without stars. These clouds might be products of an interaction, or condensations in the hot circumgalactic medium of M31, but both these models have difficulties. The prevalence of clouds like this in the Local Group remains to be determined.
The current IAU Symposium is closely connected to the EU-funded network DAGAL (Detailed Anatomy of Galaxies), with the final annual network meeting of DAGAL being at the core of this international symposium. In this short paper, we give an overview of DAGAL, its training activities, and some of the scientific advances that have been made under its umbrella.