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The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.
The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.
The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.
Availability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.
Outlet glaciers undergo rapid spatial and temporal changes in flow velocity during calving events. Observing such changes requires both high temporal and high spatial resolution methods, something now possible with terrestrial radar interferometry. While a single such radar provides line-of-sight velocity, two radars define both components of the horizontal flow field. To assess the feasibility of obtaining the two-dimensional (2-D) flow field, we deployed two terrestrial radar interferometers at Jakobshavn Isbrae, a major outlet glacier on Greenland's west coast, in the summer of 2012. Here, we develop and demonstrate a method to combine the line-of-sight velocity data from two synchronized radars to produce a 2-D velocity field from a single (3 min) interferogram. Results are compared with the more traditional feature-tracking data obtained from the same radar, averaged over a longer period. We demonstrate the potential and limitations of this new dual-radar approach for obtaining high spatial and temporal resolution 2-D velocity fields at outlet glaciers.
What does Japan's 2011 nuclear accident have in common with the 2005 flooding of New Orleans from Hurricane Katrina? This thought-provoking book presents a compelling account of recent and historical disasters, both natural and human-caused, drawing out common themes and providing a holistic understanding of hazards, disasters and mitigation, for anyone interested in this important and topical subject. Based on his on-the-ground experience with several major recent disasters, Timothy H. Dixon explores the science, politics and economics behind a variety of disasters and environmental issues, arguing that many of the worst effects are avoidable. He describes examples of planning and safety failures, provides forecasts of future disasters and proposes solutions for hazard mitigation. The book shows how billions of dollars and countless lives could be saved by adopting longer-term thinking for infrastructure planning and building, and argues that better communication is vital in reducing global risks and preventing future catastrophes.