Background: There has been an increased effort to understand the nature of obsessive-compulsive disorder (OCD) in non-Western cultures. In particular, growing research has examined OCD in China, but there are no comprehensive instruments that measure both OCD severity and heterogeneity for characterizing samples. Aims: A validated, comprehensive measure that could be used in China would provide researchers with a useful instrument for evaluating severity and heterogeneity of OCD in a non-Western culture, allowing researchers to better understand the universal and cultural components that play a role in the nature of OCD. Method: The current investigation presents data on the reliability and validity of a Mandarin translation of the Obsessive-Compulsive Inventory-Revised (CH-OCI) using both a student (n = 1950) and clinical sample (n = 50 patients with OCD; n = 50 patients with anxiety as a comparison group). Results: Results support the factor structure, convergent and discriminant validity, criterion-related validity, test-retest reliability, and internal consistency of the CH-OCI. Conclusions: Validation of the instrument permits researchers and clinicians to measure OCD presentation in Mandarin-speaking samples.