To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
One of the most remarkable processes in nature is the process of replacing or regenerating damaged tissue. Some salamander species possess the capacity to regenerate a variety of tissues and organs as adult organisms. Other higher vertebrate species also possess regenerative abilities, but these are limited to early embryonic stages and⁄or tissues that can undergo renewal (Tsonis, 2000, 2001). Lens regeneration in the adult urodele amphibian represents one of these unique processes in which major cellular events such as dedifferentiation and transdifferentiation regulate tissue replacement. Dedifferentiation involves terminally differentiated cells reentering the cell cycle and losing the typical characteristics of their origin, whereas transdifferentiation allows a cell to change its identity and become a completely different cell type. During lens regeneration, the cells that undergo this transformation are the pigment epithelial cells (PECs) of the dorsal iris. This cell-type conversion is not usually observed in terminally differentiated cells that have followed a developmental path and had been determined in phenotype and function. Cancer cells share similarities with the PECs that undergo the regenerative process. In the former, during oncogenesis, the original phenotype is destabilized and the cells divide, resulting in uncontrolled growth, eventual invasion to other organs/tissues, and the production of tumors. During lens regeneration, there must be a mechanism or program that destabilizes the cell phenotype but at the same time carefully directs these cells to divide, reorganize, and redifferentiate to new cell types that will be responsible for replacing the lost parts.
Email your librarian or administrator to recommend adding this to your organisation's collection.