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Dementia with Lewy bodies (DLB) is underrecognised in clinical
To investigate whether performing a 123I-ioflupane injection
(123I-FP-CIT also called DaTSCANTM) single
photon emission computed tomography (SPECT) scan in patients with
possible DLB would lead to a more certain diagnosis (probable DLB or
We randomised 187 patients with possible DLB 2:1 to have a scan or not
(control group). The outcome measure was a change in diagnosis to
probable DLB or non-DLB.
There were 56 controls and 114 scanned patients, of whom 43% had an
abnormal scan. More patients in the imaging group had a change in
diagnosis compared with controls at 8 and 24 weeks (61%
(n = 70) v. 4% (n =
2) and 71% (n = 77) v. 16%
(n = 9); both P<0.0001).
Clinicians were more likely to change the diagnosis if the scan was
abnormal (82%) than if it was normal (46%).
Imaging significantly contributed to a more certain diagnosis, proving to
be a useful adjunct in the work-up of patients with possible DLB.
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