An Investigation of the piezoresistive response of a metal-polymer composite based on nickel conductive filler in a polydimethylsiloxane (PDMS) insulating matrix for tactile sensor application is presented in this paper. Lacking a mechanical deformation, the prepared composites show no electric conductivity, even though the metal particle content is well above the expected percolation threshold. In contrast, when subjected to uniaxial compression, the electric resistance is strongly reduced. A variation of up to nine orders of magnitude was registered. The thickness of the insulating layer between particles decreases when the sample composite is compressed. Therefore, the electric conduction which is related to a tunneling phenomena, increases exponentially. This behavior is further enhanced by the presence of very sharp nanometric spikes on the particles surface which act as field enhancement factors. In the presented work, the piezoresistive behavior of the composite, the stability in time of the resistance value and the response to several cycles of compression and decompression are evaluated on samples with different physical parameters like nickel content, PDMS copolymer/curing agent ratio and thickness.