Herbicide-resistant Palmer amaranth is creating additional challenges for producers choosing to adopt a furrow-irrigated rice production system due to the absence of a sustained flood, enabling extended weed emergence. Fluridone has been shown to control Palmer amaranth effectively in cotton production systems and was recently registered for use in rice. Experiments were initiated in 2022 and 2023 to evaluate 1) Palmer amaranth control and rice tolerance to preemergence- and postemergence-applied fluridone at a 0.5x (84 g ai ha-1) and 1x rate (168 g ai ha-1) on a silt loam soil and 2) the effect of various herbicide programs containing fluridone on Palmer amaranth biomass, seed production, and rough rice grain yield. Preemergence applications of fluridone at a 1x rate in combination with clomazone resulted in 84% control of Palmer amaranth 21 d after treatment (DAT). Fluridone, in combination with clomazone preemergence, caused up to 36% rice injury 21 DAT; however, early season injury did not negatively affect rice yields. Palmer amaranth biomass and fecundity were reduced with herbicide programs that included fluridone plus florpyrauxifen-benzyl, and, in some instances, there was no Palmer amaranth biomass or seed production following multiple applications of both herbicides. Fluridone- and florpyrauxifen-benzyl-based herbicide programs achieved effective control of Palmer amaranth when applied timely, but injury to hybrid rice is enhanced with preemergence applications of fluridone that are not permitted with the current label.