Field studies were conducted at Carbondale and Belleville, IL to evaluate weed control in corn with a total POST herbicide program. Nicosulfuron was applied at 24 and 35 g/ha alone and in combination with 2,4-D, dicamba, bromoxynil, bentazon, atrazine, and bentazon, bromoxynil, and dicamba plus atrazine. Nicosulfuron controlled 98 to 100% of giant foxtail both years at both locations. Control of giant foxtail was reduced when nicosulfuron at 24 g/ha was applied as a tank-mix with atrazine, and with bentazon, bromoxynil, or dicamba plus atrazine at Belleville in 1991. Also, bentazon plus atrazine with nicosulfuron at 35 g/ha reduced control of giant foxtail. Control of common lambsquarters, jimsonweed, and velvetleaf was dependent on nicosulfuron rate, companion herbicide, and growing conditions. Nicosulfuron alone or as a tank-mix with the companion herbicides controlled redroot pigweed 100% at both sites both years but control of yellow nutsedge was less than 50%. Corn yield was related to level of weed control obtained in most instances.