Most tall fescue in the United States is infected with a fungal endophyte which imparts certain advantages to the plant, such as drought tolerance, insect feeding deterrence, and enhanced mineral uptake. However, the endophyte also produces ergot alkaloids that are harmful to livestock and contribute to fescue toxicosis. Because the alkaloids are concentrated in seed and stems, a potential way to reduce the likelihood of fescue toxicosis is by suppressing seedhead formation with herbicides. Research was conducted from 2012 to 2014 using metsulfuron applied alone and in combination with other herbicides in spring to determine the growth response of tall fescue, effects on forage quality, and ergot alkaloid concentration. Clipping or metsulfuron applied alone or in combination with aminocyclopyrachlor or aminopyralid reduced seedhead density by 36 to 55% compared to the nontreated control. Treatments containing metsulfuron reduced spring harvest yield 35 to 61%, but no differences were observed in the summer or year-after harvests. The same treatments increased crude protein levels by 1.03 to 2.14% and reduced acid detergent fiber levels by 1.60 to 2.76% compared to the nontreated control at spring harvest. Treatments containing metsulfuron reduced ergot alkaloid concentration 26 to 34% at the spring harvest, but no differences were observed in summer-harvested forage. Results from this study indicate metsulfuron applied alone or in combination with aminocyclopyrachlor or aminopyralid can potentially reduce the severity of fescue toxicosis and improve forage quality.