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X-ray microscopy is a field that has developed rapidly in recent years. Two different approaches have been used. Zone plates have been employed to produce focussed beams with sizes as low as 0.07 pm for x-ray energies below 1 keV. Images of biological materials and elemental maps for major and minor low Z have been produced using above and below absorption edge differences. At higher energies collimators and focussing mirrors have been used to make small diameter beams for excitation of characteristic K— or L-x rays of all elements in the periodic
Giant electromagnetic pulses (EMP) generated during the interaction of high-power lasers with solid targets can seriously degrade electrical measurements and equipment. EMP emission is caused by the acceleration of hot electrons inside the target, which produce radiation across a wide band from DC to terahertz frequencies. Improved understanding and control of EMP is vital as we enter a new era of high repetition rate, high intensity lasers (e.g. the Extreme Light Infrastructure). We present recent data from the VULCAN laser facility that demonstrates how EMP can be readily and effectively reduced. Characterization of the EMP was achieved using B-dot and D-dot probes that took measurements for a range of different target and laser parameters. We demonstrate that target stalk geometry, material composition, geodesic path length and foil surface area can all play a significant role in the reduction of EMP. A combination of electromagnetic wave and 3D particle-in-cell simulations is used to inform our conclusions about the effects of stalk geometry on EMP, providing an opportunity for comparison with existing charge separation models.
Limitations of access have long restricted exploration and investigation of the cavities beneath ice shelves to a small number of drillholes. Studies of sea-ice underwater morphology are limited largely to scientific utilization of submarines. Remotely operated vehicles, tethered to a mother ship by umbilical cable, have been deployed to investigate tidewater-glacier and ice-shelf margins, but their range is often restricted. The development of free-flying autonomous underwater vehicles (AUVs) with ranges of tens to hundreds of kilometres enables extensive missions to take place beneath sea ice and floating ice shelves. Autosub2 is a 3600 kg, 6.7 m long AUV, with a 1600 m operating depth and range of 400 km, based on the earlier Autosub1 which had a 500 m depth limit. A single direct-drive d.c. motor and five-bladed propeller produce speeds of 1–2 m s−1. Rear-mounted rudder and stern-plane control yaw, pitch and depth. The vehicle has three sections. The front and rear sections are free-flooding, built around aluminium extrusion space-frames covered with glass-fibre reinforced plastic panels. The central section has a set of carbon-fibre reinforced plastic pressure vessels. Four tubes contain batteries powering the vehicle. The other three house vehicle-control systems and sensors. The rear section houses subsystems for navigation, control actuation and propulsion and scientific sensors (e.g. digital camera, upward-looking 300 kHz acoustic Doppler current profiler, 200 kHz multibeam receiver). The front section contains forward-looking collision sensor, emergency abort, the homing systems, Argos satellite data and location transmitters and flashing lights for relocation as well as science sensors (e.g. twin conductivity–temperature–depth instruments, multibeam transmitter, sub-bottom profiler, AquaLab water sampler). Payload restrictions mean that a subset of scientific instruments is actually in place on any given dive. The scientific instruments carried on Autosub are described and examples of observational data collected from each sensor in Arctic or Antarctic waters are given (e.g. of roughness at the underside of floating ice shelves and sea ice).
We examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypothesized that antipsychotic treatment resistance is: (a) present at illness onset; and (b) differentially associated with clinical and demographic factors.
The study sample comprised 323 FEP patients who were studied at first contact and at 10-year follow-up. We collated clinical information on severity of symptoms, antipsychotic medication and treatment adherence during the follow-up period to determine the presence, course and predictors of treatment resistance.
From the 23% of the patients, who were treatment resistant, 84% were treatment resistant from illness onset. Multivariable regression analysis revealed that diagnosis of schizophrenia, negative symptoms, younger age at onset, and longer duration of untreated psychosis predicted treatment resistance from illness onset.
The striking majority of treatment-resistant patients do not respond to first-line antipsychotic treatment even at time of FEP. Clinicians must be alert to this subgroup of patients and consider clozapine treatment as early as possible during the first presentation of psychosis.
Universal screening for postpartum depression is recommended in many countries. Knowledge of whether the disclosure of depressive symptoms in the postpartum period differs across cultures could improve detection and provide new insights into the pathogenesis. Moreover, it is a necessary step to evaluate the universal use of screening instruments in research and clinical practice. In the current study we sought to assess whether the Edinburgh Postnatal Depression Scale (EPDS), the most widely used screening tool for postpartum depression, measures the same underlying construct across cultural groups in a large international dataset.
Ordinal regression and measurement invariance were used to explore the association between culture, operationalized as education, ethnicity/race and continent, and endorsement of depressive symptoms using the EPDS on 8209 new mothers from Europe and the USA.
Education, but not ethnicity/race, influenced the reporting of postpartum depression [difference between robust comparative fit indexes (∆*CFI) < 0.01]. The structure of EPDS responses significantly differed between Europe and the USA (∆*CFI > 0.01), but not between European countries (∆*CFI < 0.01).
Investigators and clinicians should be aware of the potential differences in expression of phenotype of postpartum depression that women of different educational backgrounds may manifest. The increasing cultural heterogeneity of societies together with the tendency towards globalization requires a culturally sensitive approach to patients, research and policies, that takes into account, beyond rhetoric, the context of a person's experiences and the context in which the research is conducted.
In the 1998-99 flight, BOOMERanG has produced maps of ∼4% of the sky at high Galactic latitudes, at frequencies of 90, 150, 240 and 410 GHz, with resolution ≳ 10'. The faint structure of the Cosmic Microwave Background at horizon and sub-horizon scales is evident in these maps. These maps compare well to the maps recently obtained at lower frequencies by the WMAP experiment. Here we compare the amplitude and morphology of the structures observed in the two sets of maps. We also outline the polarization sensitive version of BOOMERanG, which was flown early this year to measure the linear polarization of the microwave sky at 150, 240 and 350 GHz.
The Southern Hemisphere VLBI Experiment (SHEVE) program is aimed at producing high-resolution images of southern radio sources. The radio telescopes of the present SHEVE array are described below and some recent results presented.
The ALFA mission is designed to map the entire sky at frequencies between approximately 0.3 and 30 MHz with angular resolution limited by interstellar and interplanetary scattering. Most of this region of the spectrum is inaccessible from the ground because of absorption and refraction by the Earth’s ionosphere. A wide range of astrophysical questions concerning solar system, galactic, and extragalactic objects could be answered with high resolution images at low frequencies, where absorption effects and coherent emission processes become important and the synchrotron lifetimes of electrons are comparable to the age of the universe.
Major depressive disorder (MDD) is a common and disabling condition with well-established heritability and environmental risk factors. Gene–environment interaction studies in MDD have typically investigated candidate genes, though the disorder is known to be highly polygenic. This study aims to test for interaction between polygenic risk and stressful life events (SLEs) or childhood trauma (CT) in the aetiology of MDD.
The RADIANT UK sample consists of 1605 MDD cases and 1064 controls with SLE data, and a subset of 240 cases and 272 controls with CT data. Polygenic risk scores (PRS) were constructed using results from a mega-analysis on MDD by the Psychiatric Genomics Consortium. PRS and environmental factors were tested for association with case/control status and for interaction between them.
PRS significantly predicted depression, explaining 1.1% of variance in phenotype (p = 1.9 × 10−6). SLEs and CT were also associated with MDD status (p = 2.19 × 10−4 and p = 5.12 × 10−20, respectively). No interactions were found between PRS and SLEs. Significant PRSxCT interactions were found (p = 0.002), but showed an inverse association with MDD status, as cases who experienced more severe CT tended to have a lower PRS than other cases or controls. This relationship between PRS and CT was not observed in independent replication samples.
CT is a strong risk factor for MDD but may have greater effect in individuals with lower genetic liability for the disorder. Including environmental risk along with genetics is important in studying the aetiology of MDD and PRS provide a useful approach to investigating gene–environment interactions in complex traits.
This brief article outlines the history of John Ward-Perkins' involvement with the archaeology of the complex of buildings erected under the Severan dynasty at Lepcis Magna. The detailed survey of those superb monuments by British and Italian scholars has until now not received the level of publication which it merits. As that work finally goes to press, some explanation is given of the problems faced in preparing for publication the archive of drawings.
Two seasons of work have now been conducted by British and French survey teams, in conjunction with members of the Libyan Antiquities Department, under the charge of Dr. Abdullah Shaiboub. The objectives of the survey are to locate, survey and analyse the extensive remains of the ancient agricultural settlements that can be found in the wadis of the hinterlands of Tripolitania and the Sirtica. Within the framework established by the Department in cooperation with Unesco lies the archaeological aim of recording the evidence for periods when extensive areas of the pre-desert were, for whatever reasons, cultivated in ways that are not similarly practised today. In the longer term the programme is designed to locate those areas where modern farming might be re-established. Archaeology is thus brought into line with the aims of the modern world.
For the purposes of this report we intend to concentrate on the period which we call the Romano/Libyan in which the great majority of those farming settlements flourished. The prehistoric evidence is in any case mainly of the palaeolithic period, on which there is a separate section.
The preferred zone of settlement in Tripolitania has traditionally been the well watered coastal plain and the adjacent limestone hills of the Tarhuna Gebel as far south as the town of Beni Ulid, for these regions have more than 200 mm of rain a year, regarded as the threshold for settled farming without irrigation. Prehistoric settlement concentrated here, and mixed farming has probably characterised this zone from the fourth millennium b.c. In the Roman period the coastal cities like Sabratha and Leptis Magna were supported by prosperous farms on the plain and in the Gebel. In the Islamic period, too, the same region was densely settled.
This note gives a preliminary notice of the discovery of a further clausura in western Tripolitnia (Southern Tunisia). These linear barriers are assumed to have performed some function in customs regulation and the supervision of transhumance movements in the frontier zone, rather than being defensive barriers as such. The new discovery suggests that there may well be still others undiscovered in southern Tunisia and western Libya.
Preliminary results of survey and limited excavations at Euhesperides (Benghazi) and Tocra are discussed. At Euhesperides part of one residential insula was excavated and a mosaic discovered. Evidence is presented that the insula and the city defences are contemporary, dating from the early fourth to the third centuries BC. The earliest stratified levels beneath the floors of the insula date to the early sixth century BC. The work at Tocra comprised a full survey of all visible archaeological remains. In particular, close study and limited excavation of the Byzantine Fortress suggest that the structure survived long beyond the Arab invasions of AD 642.
Three seasons of intensive survey in the central Tripolitanian pre-desert, primarily in the regions of the Wadis Sofeggin and Zem Zem, have provided a new basis for the study of pre-desert cultures. Not only have hundreds of new sites been discovered, but the combination of environmental and geomorphological studies with archaeological survey is now providing important information about the underlying mechanisms which supported them. An increasing settlement density and social complexity can be identified in the Romano–Libyan period together with the development of intensive farming and elaborate irrigation systems. There is little evidence for significant climatic change to account for this increased settlement intensity or for its subsequent decline. The explanation for this must probably be sought in a complex relationship between social organisation, population change, and the agricultural system, and its impact on the environment.
A summary account of the Byzantine bath-house at Tocra is given. Goodchild excavated this well-preserved structure in the 1960s, but died before producing a published account. Although the evidence of some late features had been removed then, a structural analysis of the building is still possible, showing three main periods of construction and use probably extending into the early Islamic period.
This report presents the preliminary results of the final season of the UNESCO Libyan Valleys Survey, that took place in October 1989. The fieldwork was divided in two parts. The first part of the work concentrated on the settlements in the Wadi Buzra, a northern tributary of the Wadi Sofeggin, especially at Souk el Awty. The major monument here consists of a substantial church (published elsewhere by D. A. Welsby in this volume), which was investigated by architectural survey and limited excavation, as were the surrounding late Romano-Libyan farms. The modern name of the settlement suggests that it may have been an important centre in Islamic as well as the Romano-Libyan periods, but the excavation did not obtain conclusive chronological evidence. The second part of the fieldwork was in the Wadi Umm el-Kharab, a southern tributary of the Sofeggin. Here, the team carried out a detailed study of a series of fortified farms of the later Romano-Libyan period, to compare with the open farm of the earlier Romano-Libyan period in Wadi el Amud previously studied by the project. An analysis of the constructional details of the major farms was integrated with excavations to recover stratified dating evidence from within the farms and faunal and botanical evidence from associated middens, and with a survey of the water-control systems of walls down the length of the wadi. The study indicates that the wadi was settled by people living in open farms and nucleated settlements in the first four centuries AD, but that by the fifth and sixth centuries AD these were replaced by fortified farms. There is evidence that the occupants of the fortified farms cultivated the wadi within an integrated economic system characterised by centralised food storage, rather than as independent units.