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Background: Challenges in predicting risk of recurrence for individual patients with meningioma limits appropriate selection of patients who may benefit from adjuvant radiation therapy to delay recurrence. Here, we aimed to develop and validate a combined clinicomolecular predictor of early recurrence for individual patients with meningiomas. Methods: A methylation-based predictor of 5-year recurrence-free-survival (RFS) was developed using DNA-methylation profiles from a training cohort of 228 patients. Model performance was compared to a standard-of-care histological-based model using three independent cohorts (N=54 ;N=140; N=64 patients). Subsequently, a nomogram that integrated the methylome-based predictor with prognostic clinical factors was developed and validated. Results: The methylome-based predictor of 5-year RFS performed favorably compared to a grade-based predictor when tested using the three validation cohorts (ΔAUC=0.10, 95%CI 0.03 – 0.018) and was independently associated with RFS on multivariable Cox regression analysis (HR=3.6, 95%CI 1.8–7.2, P<0.001). A nomogram combining the methylome-predictor with clinical factors demonstrated greater discrimination for recurrence than a nomogram using clinical factors alone (ΔAUC=0.25, 95%CI 0.22–0.27) and resulted in two risk groups with distinct recurrence patterns (HR=7.7, 95%CI 5.3–11.1, P<0.001) and clinical implications. Conclusions: Our validated models provide important novel prognostic information that could be used to individualize decisions regarding post-operative therapeutic interventions in meningioma.
To report a case of successful bone-anchored hearing aid implantation in an adult patient with type III osteogenesis imperfecta, which is commonly regarded as a contraindication to this procedure.
A 45-year-old man with type III osteogenesis imperfecta presented with mixed hearing loss. There was a mild sensorineural component in both ears, with an air–bone gap between 45 and 50 dB HL. He was implanted with a bone-anchored hearing aid. The audiological outcome was good, with no complications and good implant stability (as measured by resonance frequency analysis).
To our knowledge, this is the first recorded case of bone-anchored hearing aid implantation in a patient with osteogenesis imperfecta.
We describe the preliminary design of a magnetograph and visible-light imager instrument to study the solar dynamo processes through observations of the solar surface magnetic field distribution. The instrument will provide measurements of the vector magnetic field and of the line-of-sight velocity in the solar photosphere. As the magnetic field anchored at the solar surface produces most of the structures and energetic events in the upper solar atmosphere and significantly influences the heliosphere, the development of this instrument plays an important role in reaching the scientific goals of The Atmospheric and Space Science Coordination (CEA) at the Brazilian National Institute for Space Research (INPE). In particular, the CEA's space weather program will benefit most from the development of this technology. We expect that this project will be the starting point to establish a strong research program on Solar Physics in Brazil. Our main aim is acquiring progressively the know-how to build state-of-the-art solar vector magnetograph and visible-light imagers for space-based platforms to contribute to the efforts of the solar-terrestrial physics community to address the main unanswered questions on how our nearby Star works.
The solar cells employed in low to medium (50 to 200 suns) concentration photovoltaic (CPV) are usually mono-crystalline silicon. Laser Groove Buried Contacts (LGBC) are preferred to screen printing in these cells due to the high currents generated in the system. In this paper, we report on the use of Coherence Correlation Interferometry (CCI) to accurately measure the width and depth of the laser-ablated grooves. In addition, the technique is also used to measure the surface roughness at the bottom of the trenches, since this can determine the success of the subsequent plating process, and at the top surface to optimize the debris control and obtain clean surfaces and well-shaped groove edges. The laser ablation process was also optimized to obtain the groove aspect ratio and surface quality required. Process parameters to be controlled include laser power, pulse energy, stage speed and focal length. The CCI technique is capable of providing all the groove and surface metrology required for this process optimization.
The studies developed at CST sinter plant in order to point out any factor that may have an effect on plume visibility are reported. Specific software and indexes have been developed. The approach included a retrospective analysis followed by further industrial tests at the sinter plant with different material input (fuels and raw materials). The results are discussed with reference to potential effects on the plume visibility. Further steps are considered to progress the stack plume project.
Thin film nanogranular composites of cobalt ferrite (CoFe2O4) dispersed in a barium titanate (BaTiO3) matrix were deposited by laser ablation with different cobalt ferrite concentrations (x). The films were polycrystalline and composed by a mixture of tetragonal-BaTiO3 and CoFe2O4 with the cubic spinnel structure. A slight (111) barium titanate phase orientation and (311) CoFe2O4 phase orientation was observed. As the concentration of the cobalt ferrite increased, the grain size of the BaTiO3 phase decreased, from 91nm to 30nm, up to 50% CoFe2O4 concentration, beyond which the BaTiO3 grain size take values in the range 30-35nm. On the other hand the cobalt ferrite grain size did not show a clear trend with increasing cobalt ferrite concentration, fluctuating in the range 25nm to 30nm. The lattice parameter of the CoFe2O4 phase increased with increasing x. However, it was always smaller than the bulk value indicating that, in the films, the cobalt ferrite was under compressive stress that was progressively relaxed with increasing CoFe2O4 concentration. The magnetic measurements showed a decrease of coercive field with increasing x, which was attributed to the relaxation of the stress in the films and to the increase of particle agglomeration in bigger polycrystalline clusters with increasing cobalt ferrite concentration.
Large area (4x4 cm2) optical signal and image processing (OSIP) devices were produced at low temperatures (110°C) by PE-CVD. The OSIP device consists of two stacked sensing/switching diodes (p(SiC:H)/i(Si:H)/n(SiC:H)) with or without an internal blocking layer between them and two semitransparent contacts. An optical scanner is used for charge readout. In this work the main emphasis will be put on the analysis of the optical characteristics. The use of a metal grid (290x290 μm2 Cr pixels with 40 m m spacing) between the two diodes, working as light screening layer or as floating anode via an a-SiN insulator layer, is analyzed. Its influence on the transfer functions, resolution, responsivity and response time of the sensor is presented. The various design parameters trade-offs are discussed. The optical-to-electrical transfer characteristics show high quantum efficiency, broad spectral response, and reciprocity between the optical and the electrical images. When the light screening floating anode is present an effective optical decoupling from both photodiodes is achieved while maintaining a good electrical conductivity and an increased light-to-dark sensitivity. A trade-off is established between sensor design and light pattern and scanner wavelengths in order to minimize the cross talk between the write and the read beams and to improve the light to dark sensitivity.
Strontium barium niobate (SBN) thin films were crystallized by conventional electric furnace annealing and by rapid-thermal annealing (RTA) at different temperatures. The average grain size of films was 70 nm and thickness around 500 nm. Using x-ray diffraction, we identified the presence of polycrystalline SBN phase for films annealed from 500 to 700 °C in both cases. Phases such as SrNb2O6 and BaNb2O6 were predominantly crystallized in films annealed at 500 °C, disappearing at higher temperatures. Dielectric and ferroelectric parameters obtained from films crystallized by conventional furnace and RTA presented essentially the same values.
Theoretical calculations are performed on the role of smooth interfaces in the Raman spectra of Si/3C-SiC superlattices. The dispersion relations were obtained using a linear chain model with the alloyed interface δ-(3C-SiC)0.5(Si)0.5 described in the virtual crystal approximation. A modified bond-polarizability model was used to calculate the Raman spectra. The main results are the enhancement of the Raman spectra and the appearance of new peaks in between those related to the Si quasi confined and the 3C-SiC-confined modes with increasing number δ?of interfacial monolayers (3C-SiC)0.5(Si)0.5. Some of the smooth interface related Raman peaks have intensity comparable with those of an abrupt Si/3C-SiC superlattice.
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