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Cognitive deficits in schizophrenia consist of deficits in attention, concentration, fluency, and executive function. Especially the working memory deficits influence everyday function and rehabilitation.
The ame of the study was to investigate a potential of a neurocognitive intervention in schizophrenia (CS) and multiple sclerosis (MS) by application of a computerised working memory training.
So far, 30 ms patients and 14 cs patients were investigated. Patients are allocated to a treatment group or to a control design. At baseline, all participants underwent a comprehensive neuropsychological examination including memory, working memory, attention, concentration, information processing speed, mental flexibility and intelligence. The treatment group performed a computer program (Brainstim®) four times a week over a period of four weeks. After 16 training sessions all participants were evaluated again neuropsychologically.
In both patient groups a significant increase in cognitive performance within the training procedure could be shown. This increase was expressed by an initial exponential function with a steep increase and an asymptotic slope. Pre-post-test-comparisons revealed significant improvement for shortterm and working memory on the neuropsychological outcomes. The program was well accepted by the patients.
This preliminary results show, that working memory might be trained in schizophrenia and thus it might interfere positively the cognitive und rehabilitative outcome.
Bipolar disorders have a high impact and are psychosocially very relevant. Their manifestation have a broad variety of forms and cognitive and neuropsychological functioning is impaired in acute illness. There is a lack of neuropsychological research during remission of bipolar illness. The aim of this study was to evaluate the cognitive status of remitted bipolar patients.
38 remitted bipolar patients underwent neuropsychological testing: MWT-B, TMT, VLMT, WMS-R, D2 and proactive interference. The results were compared with a sample of 32 schizoaffective patients.
The scores of bipolar patients were in average in most of the applied instruments. The patients had lower results in only some fields of cognitive functioning, e.g. proactive interference. Bipolar patients had significantly better results compared to the group of schizoaffective patients.
Remitted bipolar patients had fairly good results in neurocognitive functioning. Compared to schizoaffective patients cognitive flexibility, concentration and memory is better.
Schizoaffective disorders have a long history and are clinically relevant, but their concept is still uncertain. Cognitive and neuropsychological functioning is impaired in acute illness, but deficits are obvious even during remission. The aim of this study was to evaluate the cognitive status of remitted schizoaffective patients.
32 remitted patients diagnosed to have schizoaffective disorder underwent neuropsychological testing: MWT-B, TMT, VLMT, WMS-R, D2 and proactive interference. The results were compared with a sample of 38 bipolar patients.
The scores of schizoaffective patients were under the average in all of the applied instruments. The patients had lower results compared to the group of bipolar patients.
Even in remission patients with schizoaffective disorder have neurocognitive deficits. Compared to healthy probands or bipolar patients cognitive flexibility, concentration and memory is worse.
Transpersonal, meaning beyond the ego-boundaries, was first used by Assagioli. After that the term has been used to indicate an attention to the transcendent or spiritual dimension of humanity, both in philosophy and psychology. In psychotherapy the term transpersonal refers also to the exploration of altered state of consciousness with healing purposes. Starting from these premises P.L. Lattuada developed a model called Biotransenergetica. In such a method the attention is directed to the person in his/her wholeness not just to the symptoms. The core concept is the transe, which refers to a process of being in harmonic equilibrium within oneself and with the surrounding. Symptoms are view as allies showing where the process is blocked, so that the transe is disharmonic, causing physical as well as psychological suffering. The therapeutic process is a way to read the process that led to a disharmonious transe and help the client in a self-healing process, which also will lead toward a self-realization. Transpersonal psychology has been criticized by some authors challenging its definitions that link transpersonal psychology to healthy states only. Moreover recalling the spiritual dimension puts at risk the application of transpersonal psychotherapy in a clinical setting, where scientific evidence based approach is requested. However our clinical experience demonstrates that BTE can be applied in a therapeutic context. Aim of this presentation is to show the clinical application of this model describing how disease and symptoms could be revised in terms of harmonic transe and self-realization.
Immune system markers may predict affective disorder treatment response, but whether an overall immune system marker predicts bipolar disorder treatment effect is unclear.
Bipolar CHOICE (N = 482) and LiTMUS (N = 283) were similar comparative effectiveness trials treating patients with bipolar disorder for 24 weeks with four different treatment arms (standard-dose lithium, quetiapine, moderate-dose lithium plus optimised personalised treatment (OPT) and OPT without lithium). We performed secondary mixed effects linear regression analyses adjusted for age, gender, smoking and body mass index to investigate relationships between pre-treatment white blood cell (WBC) levels and clinical global impression scale (CGI) response.
Compared to participants with WBC counts of 4.5–10 × 109/l, participants with WBC < 4.5 or WBC ≥ 10 showed similar improvement within each specific treatment arm and in gender-stratified analyses.
An overall immune system marker did not predict differential treatment response to four different treatment approaches for bipolar disorder all lasting 24 weeks.
To characterize the multiple dimensions and benefits of the Mediterranean diet as a sustainable diet, in order to revitalize this intangible food heritage at the country level; and to develop a multidimensional framework – the Med Diet 4.0 – in which four sustainability benefits of the Mediterranean diet are presented in parallel: major health and nutrition benefits, low environmental impacts and richness in biodiversity, high sociocultural food values, and positive local economic returns.
A narrative review was applied at the country level to highlight the multiple sustainable benefits of the Mediterranean diet into a single multidimensional framework: the Med Diet 4.0.
We included studies published in English in peer-reviewed journals that contained data on the characterization of sustainable diets and of the Mediterranean diet. The methodological framework approach was finalized through a series of meetings, workshops and conferences where the framework was presented, discussed and ultimately refined.
The Med Diet 4.0 provides a conceptual multidimensional framework to characterize the Mediterranean diet as a sustainable diet model, by applying principles of sustainability to the Mediterranean diet.
By providing a broader understanding of the many sustainable benefits of the Mediterranean diet, the Med Diet 4.0 can contribute to the revitalization of the Mediterranean diet by improving its current perception not only as a healthy diet but also a sustainable lifestyle model, with country-specific and culturally appropriate variations. It also takes into account the identity and diversity of food cultures and systems, expressed within the notion of the Mediterranean diet, across the Mediterranean region and in other parts of the world. Further multidisciplinary studies are needed for the assessment of the sustainability of the Mediterranean diet to include these new dimensions.
This paper presents the design of a multi-channel reconfigurable front-end architecture for a waveform-agile radar. At first the purpose of the design is explained following the status of research on software-defined radar at MTSR. A description of the proposed system architecture is given with details on sub-systems implementation. Then some preliminary results obtained on a prototype of the platform are shown. Finally, further developments on this system architecture are described, highlighting how this platform can support research on software-defined multi-channel radar systems.
Few controlled studies examine the treatment of depressive features in mania.
To evaluate the efficacy of olanzapine, in combination with lithium or valproate, for treating depressive symptoms associated with mania.
Secondary analysis of a 6-week, double-blind, randomised study of olanzapine (5–20 mg/day) or placebo combined with ongoing valproate or lithium open treatment for 344 patients in mixed or manic episodes. This analysis focused on a dysphoric subgroup with baseline Hamilton Rating Scale for Depression (HRSD) total scores of 20 or over contrasted with non-dysphoric patients.
In the dysphoric subgroup (n=85) mean HRSD total score improvement was significantly greater in olanzapine co-therapy patients than in those receiving placebo plus lithium or valproate (P<0.001). Substantial contributors to this superiority included the HRSD Maier sub-scale (P=0.013) and the suicide item (P=0.001). Total Young Mania Rating Scale improvement was also superior with olanzapine co-therapy.
In patients with acute dysphoric mania, addition of olanzapine to ongoing lithium or valproate monotherapy significantly improved depressive symptom, mania and suicidality ratings.
A process for creating patterns of metal-binding ligands on a variety of substrates is described. Deep UV patterning of chemisorbed ligand-bearing organosilane films creates modified surfaces that can selectively bind species such as Pd(II) via a covalent metal ion-ligand interaction. Patterned surface-bound Pd(II) is used to initiate additive electroless metallization at the catalytic sites. Metal adhesion to the substrate is controlled by the nature of the catalyst-ligand interaction.
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