Objective: To study the implications of hormone replacement therapy (HRT) treatment in the pathogenesis of Reinke's oedema (via a possible pseudo-hypothyroidism effect), and also to study why the disease affects a predominantly post-menopausal female population.
Design: Prospective case series study.
Setting: Two teaching hospitals and two district general hospitals in Scotland, UK.
Subjects: Thirty-three patients diagnosed with Reinke's oedema who presented in the out-patient department before or after treatment.
Results: Thyroid function tests were normal in all but two cases. Only three patients were receiving HRT treatment.
Conclusions: The study produced no evidence to support a relationship between HRT treatment and the pathogenesis of Reinke's oedema; this supports previous studies which concluded that thyroid function was not related to the development of Reinke's oedema. Some new ideas regarding hormonal factors in Reinke's oedema are discussed.