Field and laboratory studies were conducted in 1985 and 1986 to determine the effect of herbicide application timing and level of corn residue on metribuzin plus metolachlor for weed control in soybean. Herbicides were applied early preplant (35 days before planting), sequentially (early preplant and preemergence), or preemergence. Giant foxtail control was better with sequential application than early preplant herbicide application in both years. Control of velvetleaf, smooth pigweed, and jimsonweed was independent of application timing, except in 1986, when jimsonweed control was less from herbicides applied early preplant compared to sequentially. Metribuzin reaching the soil was less when applied to high levels of corn residue compared to low residue levels. However, corn residue level had no effect on weed control.