Although the hippocampus has been found to be smaller in people with
depression, the clinical relevance of this is unclear. We investigated
hippocampal volume (using high-resolution magnetic resonance imaging) and
2-year outcome in 57 patients with major depression. The left and right
hippocampal volumes of patients with a depression relapse were significantly
smaller than those of healthy controls. Our results support the hypothesis
that the hippocampus is crucial in the outcome of depression.