The integration of conservation agriculture with the benefits of precision farming represents an innovative feature aimed to achieve better economic and environmental sustainability. The synergy between these principles was assessed through a technical feasibility and energy efficiency to define the best approach depending on different agricultural systems, spatial and temporal field variability. The study compares three conservation tillage techniques supported by precision farming with conventional tillage in a specific crop rotation: wheat, rapeseed, corn and soybean. The preliminary results show a positive response of precision farming in all the conservation tillage systems, increasing yields until 22%. The energy efficiency achieves highest level in those techniques supported by precision farming, gaining peak of 9% compared to conventional tillage.