Fused silica is an optical material with excellent performance, and it is widely used in the fabrication of optics in various high-power laser systems. With the gradual improvement of laser systems, the quality of optics becomes crucial. Taking magnetorheological finishing (MRF), ion beam sputtering etching (IBSE), and advanced mitigation processing (AMP) as the means, this work focuses on exploring the damage characteristics evolution of fused silica under different techniques. In this work, IBSE technique was used to determinedly polish the optical surface after removing damage layer by MRF technique, and AMP technique was applied to etch the surface with a certain depth. Then, 10 J/cm2 (355 nm, 5 ns) laser was used to irradiate the optical surface, and the damage density of optics maintained at a low level, about 0.001/mm2, which proves that MRF, IBSE, and AMP techniques can effectively improve the laser damage resistance of optics.

Maternal syphilis not only seriously affects the quality of life of pregnant women themselves but also may cause various adverse pregnancy outcomes (APOs). This study aimed to analyse the association between the related factors and APOs in maternal syphilis. 7,030 pregnant women infected with syphilis in Henan Province between January 2016 and December 2022 were selected as participants. Information on their demographic and clinical characteristics, treatment status, and pregnancy outcomes was collected. Multivariate logistic regression models and chi-squared automatic interaction detector (CHAID) decision tree models were used to analyse the factors associated with APOs. The multivariate logistic regression results showed that the syphilis infection history (OR = 1.207, 95% CI, 1.035–1.409), the occurrence of abnormality during pregnancy (OR = 5.001, 95% CI, 4.203–5.951), not receiving standard treatment (OR = 1.370, 95% CI, 1.095–1.716), not receiving any treatment (OR = 1.313, 95% CI, 1.105–1.559), and a titre ≥1:8 at diagnosis (OR = 1.350, 95%CI, 1.079–1.690) and before delivery (OR = 1.985, 95%CI, 1.463–2.694) were risk factors. A total of six influencing factors of APOs in syphilis-infected women were screened using the CHAID decision tree model. Integrated prevention measures such as early screening, scientific eugenics assessment, and standard syphilis treatment are of great significance in reducing the incidence of APOs for pregnant women infected with syphilis.

We present the third data release from the Parkes Pulsar Timing Array (PPTA) project. The release contains observations of 32 pulsars obtained using the 64-m Parkes ‘Murriyang’ radio telescope. The data span is up to 18 yr with a typical cadence of 3 weeks. This data release is formed by combining an updated version of our second data release with $\sim$3 yr of more recent data primarily obtained using an ultra-wide-bandwidth receiver system that operates between 704 and 4032 MHz. We provide calibrated pulse profiles, flux density dynamic spectra, pulse times of arrival, and initial pulsar timing models. We describe methods for processing such wide-bandwidth observations and compare this data release with our previous release.

A new compact wideband filtering balun based on substrate-integrated suspended line technology is presented in this brief. The proposed device is composed of a λg/4 suspended stripline open-circuited stub, a λg/2 suspended stripline resonator, and a λg/2 suspended slotline resonator. These striplines and slotline are encapsulated in an electromagnetic (EM) shielding box consisting of air cavity, surrounding substrate layers, and metal layers to achieve EM shielding performance. By properly exciting the suspended stripline and slotline resonators, three transmission poles are generated to achieve high frequency selectively. The intrinsic 180∘ phase difference between the two output ports can be obtained by using the electric field distribution caused by the perpendicular coupling between the suspension stripline and the slotline resonator. The wideband passband is achieved with magnitude balance and out-of-phase properties. To validate our proposal, a wideband filtering balun operating at 2.56 GHz with fractional bandwidth of 65.6% is designed and fabricated.

Two wideband bandstop filters (BSFs) for single and dual-band are proposed and then extended to reflectionless BSFs based on the analysis from input impedance/admittance perspective. Also, topologies of higher-number-stopband input-reflectionless BSF are provided to broaden the design scope. Open/shorted coupled lines are adopted to obtain multi transmission zeros and desired stopband bandwidth by adjusting the even-/odd-mode impedance of coupled lines. Resistor-loaded coupled lines are connected with Port 1 to absorb unwanted signals and obtain input-reflectionless behavior. For validation of the proposed theory analysis, BSFs with corresponding absorptive prototypes are constructed and measured.

Objectives: Medical devices and the hospital environment can be contaminated easily by multidrug-resistant bacteria. The effectiveness of cleaning practices is often suboptimal because environmental cleaning in hospitals is complex and depends on human factors, the physical and chemical characteristics of environment, and the viability of the microorganisms. Ultraviolet-C (UV-C) lamps can be used to reduce the spread of microorganisms. We evaluated the effectiveness of an ultraviolet-C (UV-C) device on terminal room cleaning and disinfection. Methods: The study was conducted at an ICU of a medical center in Taiwan. We performed a 3-stage evaluation for the effectiveness of UV-C radiation, including pre–UV-C radiation, UV-C radiation, and a bleaching procedure. The 3 stages of evaluation were implemented in the ICU rooms from which a patient had been discharged or transferred. We collected the data from adenosine triphosphate (ATP) bioluminescence testing, colonized strains, and their corresponding colony counts by sampling from the environmental surfaces and air. We tested 8 high-touch surfaces, including 2 sides of bed rails, headboards, footboards, bedside tables, monitors, pumping devices, IV stands, and oxygen flow meters. Results: In total, 1,696 environmental surfaces and 72 air samples were analyzed. The levels of ATP bioluminescence and colony counts of isolated bacteria decreased significantly after UV-C radiation and bleaching disinfection for both the environmental and air samples (P < .001). Resistant bacteria (vancomycin-resistant Enterococcus, VRE) were commonly isolated on the hard-to-clean surfaces of monitors, oxygen flow meters, and IV pumps. However, they were also eradicated (P < .001). Conclusions: UV-C can significantly reduce environmental contamination by multidrug-resistant microorganisms. UV-C is an effective device to assist staff in cleaning the hospital environment.

To explore the effect of yield stress on the secondary breakup of gel drops, experimental and theoretical investigations are carried out by employing a high-speed camera. A unique hemline-type breakup, as a modified behaviour of sheet-thinning breakup, occurs when the air velocity increases to a high region. The edges of the drops constantly deform into thin membranes when the high-velocity air skims over the gel drops. These membranes vibrate vertically, and breaking points occur at high amplitudes, causing the formation of reticular fragments. The results of linear stability analysis indicated that the yield stress of the gel drops has an influence on the formation and breakup of the gel membranes. The breakup regime map and breakup times are also studied.

Recently, the collisionless pitch-angle scattering for relativistic runaway electrons (REs) in toroidal geometries such as tokamaks was discovered through a full orbit simulation approach (Liu et al., Nucl. Fusion, vol. 56, 2016, p. 064002), and it was then theoretically investigated that a new expression for the magnetic moment, including the second-order corrections, could essentially reproduce the so-called collisionless pitch-angle scattering process (Liu et al., Nucl. Fusion, vol. 58, 2018, p. 106018). In this paper, with synchrotron radiation, extensive numerical verification of the validity of the high-order guiding-centre theory is given for simulations involving REs by incorporating such an expression for the magnetic moment into our particle tracing code. A high-order guiding-centre simulation approach with synchrotron radiation (HGSA) is applied. Synchrotron radiation plays an essential role in the life cycle of REs. The energy of REs first increases and then becomes saturated until the electric field acceleration is balanced by the radiation dissipation. Unfortunately, the process cannot be simulated accurately with the standard guiding-centre model, i.e. the first-order guiding-centre model. Remarkably, it is found that the HGSA can effectively produce the fundamental process of REs. Since the time scale of the energy saturation of REs is close to seconds, the computational cost becomes significant. In order to save costs, it is necessary to estimate the time of energy saturation. An analytical estimate is derived for the time it takes for synchrotron drag to balance an accelerating electric field and the provided formula has been numerically verified. Test calculations reveal that HGSA is favourable for exploiting the dynamics of REs in tokamak plasmas.

In this study, a toroidal quartz ( $20\overline{2}3$ ) crystal is designed for monochromatic X-ray imaging at 72.3°. The designed crystal produces excellent images of a laser-produced plasma emitting He-like Ti X-rays at 4.75 keV. Based on the simulations, the imaging resolutions of the spherical and toroidal crystals in the sagittal direction are found to be 15 and 5 μm, respectively. Moreover, the simulation results show that a higher resolution image of the source can be obtained by using a toroidal crystal. An X-ray backlight imaging experiment is conducted using 4.75 keV He-like Ti X-rays, a 3 × 3 metal grid, an imaging plate and a toroidal quartz crystal with a lattice constant of 2d = 0.2749 nm. The meridional and sagittal radii of the toroidal α-quartz crystal are 295.6 and 268.5 mm, respectively. A highly resolved image of the microgrid, with a spatial resolution of 10 μm, is obtained in the experiment. By using similar toroidal crystal designs, the application of a spatially resolved spectrometer with high-resolution X-ray imaging ability is capable of providing imaging data with the same magnification ratio in the sagittal and meridional planes.

Since embryonic stem cells (ESCs) were first identified, significant progress has been achieved. However, the establishment of buffalo ESCs (bESCs) is still unclear. This study was undertaken to explore the effect of the blastocyst stage on the isolation of bESCs. Firstly, our results indicated that the pluripotent genes were mainly expressed at the early stages of blastocyst, and the attachment and colony formation rates of bESCs derived from expanded blastocyst and hatched blastocyst were significantly higher than early blastocyst and blastocyst. In the meantime, bESCs showed positive alkaline phosphatase activity and expressed genes like OCT4, NANOG, SOX2, c-MYC, CDH1, KLF4, and TBX3. Immunofluorescence also confirmed the expression of OCT4, SOX2. Embryoid bodies expressing three marker genes were generated from the differentiation experiment, and fibroblast, epithelial, and neuron-like cells were induced. Moreover, naive-related genes KLF4, TBX3, primed-related genes FGF5, ACTA2 were expressed in the cells, but not REX-1. Immunofluorescence and western blot confirmed the FGF5 expression. Furthermore, bESCs could maintain pluripotency with the signal of LIF and bFGF. In summary, our results indicated that expanded blastocyst and hatched blastocyst are more suitable for bESCs isolation.

There have been growing uses of semantic networks in the past decade, such as leveraging large-scale pre-trained graph knowledge databases for various natural language processing (NLP) tasks in engineering design research. Therefore, the paper provides a survey of the research that has employed semantic networks in the engineering design research community. The survey reveals that engineering design researchers have primarily relied on WordNet, ConceptNet, and other common-sense semantic network databases trained on non-engineering data sources to develop methods or tools for engineering design. Meanwhile, there are emerging efforts to mine large scale technical publication and patent databases to construct engineering-contextualized semantic network databases, e.g., B-Link and TechNet, to support NLP in engineering design. On this basis, we recommend future research directions for the construction and applications of engineering-related semantic networks in engineering design research and practice.

In this paper, the inverse kinematics (IK) of redundant manipulators is presented and studied, where the performance of end-effector path planning is guaranteed. A new Jacobian pseudoinverse (JP)-based IK method is proposed and studied using a typical numerical difference rule to discretize the existing IK method based on JP. The proposed method is depicted in a discrete-time form and is theoretically proven to exhibit great performance in the IK of redundant manipulators. A discrete-time repetitive path planning (DTRPP) scheme and a discrete-time obstacle avoidance (DTOA) scheme are developed for redundant manipulators using the proposed method. Comparative simulations are conducted on a universal robot manipulator and a PA10 robot manipulator to validate the effectiveness and superior performance of the DTRPP scheme, the DTOA scheme, and the proposed JP-based IK method.

The Qinghai–Tibetan Plateau and Arctic both have an important influence on global climate, but the correlation between climate variations in these two regions remains unclear. Here we reconstructed and compared the summer temperature anomalies over the past 1,120 yr (900–2019 CE) in the Qinghai–Tibetan Plateau and Arctic. The temperature correlation during the past millennium in these two regions has a distinct centennial variation caused by volcanic eruptions. Furthermore, the abrupt weak-to-strong transition in the temperature correlation during the sixteenth century could be analogous to this type of transition during the Modern Warm Period. The former was forced by volcanic eruptions, while the latter was controlled by changes in greenhouse gases. This implies that anthropogenic, as opposed to natural, forcing has acted to amplify the teleconnection between the Qinghai–Tibetan Plateau and Arctic during the Modern Warm Period.

Somatic cell nuclear transfer (SCNT) holds vast potential in agriculture. However, its applications are still limited by its low efficiency. Histone 3 lysine 9 trimethylation (H3K9me3) was identified as an epigenetic barrier for this. Histone demethylase KDM4D could regulate the level of H3K9me3. However, its effects on buffalo SCNT embryos are still unclear. Thus, we performed this study to explore the effects and underlying mechanism of KDM4D on buffalo SCNT embryos. The results revealed that compared with the IVF embryos, the expression level of KDM4D in SCNT embryos was significantly lower at 8- and 16-cell stage, while the level of H3K9me3 in SCNT embryos was significantly higher at 2-cell, 8-cell, and blastocyst stage. Microinjection of KDM4D mRNA could promote the developmental ability of buffalo SCNT embryos. Furthermore, the expression level of ZGA-related genes such as ZSCAN5B, SNAI1, eIF-3a, and TRC at the 8-cell stage was significantly increased. Meanwhile, the pluripotency-related genes like POU5F1, SOX2, and NANOG were also significantly promoted at the blastocyst stage. The results were reversed after KDM4D was inhibited. Altogether, these results revealed that KDM4D could correct the H3K9me3 level, increase the expression level of ZGA and pluripotency-related genes, and finally, promote the developmental competence of buffalo SCNT embryos.