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In low-and middle-income countries people with schizophrenia are reported
to experience better outcomes than those in high-income countries
To examine structural brain differences in people with first-episode
psychosis and controls in Brazil
Magnetic resonance imaging using voxel-based morphometry was performed on
122 people with first-episode psychosis and 94 controls
There were significant decreases in grey matter in the left superior
temporal and inferior prefrontal cortices, insula bilaterally and the
right hippocampal region in first-episode psychosis
(P<0.05, corrected for multiple comparisons). The
subgroup of people with schizophrenia (n=62) exhibited a
similar pattern of decrease in grey matter relative to controls
Structural abnormalities reported in psychosis in high-income countries
are also present in first-episode psychosis in Brazil
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