We report radial velocity studies of photospheric absorption lines from spectral time series of the late O-type runaway supergiant HD 188209. Radial velocity variations with a quasi-period ∼ 2 days have been detected in high-resolution echelle spectra and most probably indicate that the supergiant is pulsating. Night-to-night variations in the position and strength of the central emission reversal of the Hα profile have been observed. The fundamental parameters of the star have been derived using state-of-the-art plane-parallel and unified non-LTE model atmospheres, these last including the mass-loss rate. The binary nature of this star is not suggested either from Hipparcos photometry or from radial-velocity curves.