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Building on the recent advances in next-generation sequencing, the integration of genomics, proteomics, metabolomics, and other approaches hold tremendous promise for precision medicine. The approval and adoption of these rapidly advancing technologies and methods presents several regulatory science considerations that need to be addressed. To better understand and address these regulatory science issues, a Clinical and Translational Science Award Working Group convened the Regulatory Science to Advance Precision Medicine Forum. The Forum identified an initial set of regulatory science gaps. The final set of key findings and recommendations provided here address issues related to the lack of standardization of complex tests, preclinical issues, establishing clinical validity and utility, pharmacogenomics considerations, and knowledge gaps.
We have assembled a new sample of some of the most FIR-luminous galaxies in the Universe and have imaged them in 1.1 mm dust emission and measured their redshifts 1 < z < 4 via CO emission lines using the 32-m Large Millimeter Telescope / Gran Telescopio Milimétrico (LMT/GTM). Our sample of 31 submm galaxies (SMGs), culled from the Planck and Herschel all-sky surveys, includes 14 of the 21 most luminous galaxies known, with LFIR > 1014L⊙ and SFR > 104M⊙/yr. These extreme inferred luminosities – and multiple / extended 1.1 mm images – imply that most or all are strongly gravitationally lensed, with typical magnification μ ~ 10 × . The gravitational lensing provides two significant benefits: (1) it boosts the S/N, and (2) it allows investigation of star formation and gas processes on sub-kpc scales.
The author draws upon his experience and observations outside academia to provide ten suggestions for graduate students in political science who are exploring nonacademic career options. Their mentors may also find this advice useful.
It is very tempting to try to reconcile perception and cognition
perceptual symbol systems may be a good way to achieve this; but is
there actually a perception-cognition continuum? We offer several
arguments for and against the existence of such a continuum and in favor
of the choice of perceptual symbol systems. One of these arguments is
purely theoretical, some are based on PET-scan observations and others
are based on research with handicapped subjects who have communication
problems associated with cerebral lesions. These arguments suggest
that modal perceptual symbols do indeed exist and that perception
and cognition might have a common neuronal basis; but perceptual
and cognitive activities require the activation of different
The Countries of Latin America and the Caribbean, and consequently their relations with the United States, have changed considerably during the past 25 years. Latin American and Caribbean nations are more populous, urban, industrialized, organized, and assertive than they were a generation ago. Even in a period of extensive economic difficulty, Latin America's nations are today more prosperous than in 1960. Most are better integrated into the world economy and are much more involved in international politics.
NO country in Latin America, and few anywhere in the third world, was the subject of more social science writing during the late 1970s
and early 1980s than Peru. Books, monographs, articles, and dissertations poured forth from Peru itself, from elsewhere in Latin America, and from the United States, Western Europe, and even the Soviet Union and Japan.
In  Kleene gave a definition of recursive functionals of finite type. Later Sacks  and Harrington  gave definitions of recursion in normal functionals of finite type. These definitions, that Sacks and Harrington assumed equivalent as far as normal objects are concerned, are nevertheless very different: Kleene's definition is given in terms of an inductive definition; Sacks uses simultaneously a hierarchy (the SσF's) and induction on the ordinals and on the type; Harrington's universe does not use the induction on the type but uses a hierarchy as Shoenfield . In this paper we prove in detail that, as was expected, the three definitions are equivalent.
An extensive literature analyzes military participation in Latin American politics. Case studies and a few comparative works undermine the faith of a decade ago—that military involvement in Latin American politics would decline as a result of economic development, social modernization, military professionalization, and American influence. Attention has turned increasingly to die variety of military involvements: direct and indirect; personal, factional, and institutional; intermittent and long-term; reformist and regressive. Analyses stressing the confluence and interaction of macro-social factors with those internal to the military institution seem most persuasive in explaining the diverse political roles played by Latin American officers. One central proposition which deserves further research is that the relation between the levels of military institutionalization and the institutionalization of civilian political procedures importantly affects these varying roles.
Several years ago, in a general essay on Dominican politics, I wrote a few pages about the political role of the Dominican Armed Forces. I argued that “the history of the past few years in the Dominican Republic may best be viewed as a constant struggle among changing alliances, not in terms of confrontation between civilian authority and the military establishment” (Lowenthal, 1969: 40). I suggested that “far from being a professional institution dedicated to certain principles that impel its occasional entry into politics, the Dominican Armed Forces have never had any significant function beyond politics, except for plunder” (Lowenthal, 1969: 40). Painting a picture of constant struggle within the Dominican Armed Forces, for power and a chance at the spoils, I played down the importance, for understanding the political role of Dominican military officers, of institutional and ideological considerations.