This paper provides an overview of the U.S. Department of Energy’s (DOE) hydrogen and fuel cell activities within the Office of Energy Efficiency and Renewable Energy (EERE), focusing on key targets, progress towards meeting those targets, and materials-related issues that need to be addressed. The most recent, state-of-the-art data on metrics such as cost, durability, and performance of fuel cell and hydrogen technologies are presented. Key technical accomplishments to date include a 50% reduction in the modeled high volume cost of fuel cells since 2006, and an 80% cost reduction for electrolyzers since 2002. The statuses of various hydrogen production, delivery, and storage technologies are also presented along with a summary of materials-related challenges for hydrogen infrastructure technologies such as compression, dispensing, seals, pipeline materials/embrittlement, and storage materials. Specific examples and areas requiring more research are discussed. Finally, future plans including EERE’s lab consortium approach such as HyMARC (Hydrogen Storage Materials Advanced Research Consortium) and FC-PAD (Fuel Cell Performance and Durability) Consortia, are summarized.