Rattail fescue infestations are increasing in dryland conservation-tillage winter wheat cropping systems in the inland Pacific Northwest (PNW) region of Idaho, Oregon, and Washington. Rattail fescue typically is controlled with cultivation in conventional tillage farming systems. However, reduced soil disturbance has allowed infestations to increase significantly. The objectives of this research were to determine the effectiveness of glyphosate rates and application timings on control of rattail fescue during a chemical-fallow period in winter wheat cropping systems. Chemical-fallow field studies were conducted during two growing seasons at nine sites throughout the PNW. Glyphosate was applied early POST, late POST, or sequentially in early plus late POST timings. Additionally, paraquat + diuron was applied early and late POST alone or sequentially with glyphosate. Sequential application treatments (glyphosate followed by [fb] glyphosate, paraquat + diuron fb glyphosate, and glyphosate fb paraquat + diuron) controlled rattail fescue (∼ 94% in Idaho and Washington, ∼ 74% in Oregon) and reduced panicle number (∼ 85% in Idaho, ∼ 30% in Oregon and Washington) equivalent to or greater than one-time treatments. Rattail fescue control and panicle reduction generally increased with increasing rates of glyphosate within application timings. Paraquat + diuron usually provided similar control and reduced rattail fescue panicle number compared to glyphosate treatments applied at the same application timing. Although not completely effective, sequential applications of either glyphosate or paraquat + diuron, fb glyphosate will provide effective control during chemical fallow.