Dysarthria is characterized by dysfunction of the structures implicated in the control, initiation, and coordination of speech output: lips, tongue, jaw, palate, and larynx, which are innervated by the facial, glossopharyngeal, vagal, and hypoglossal nerves. Lesions that cause dysarthria occur in one of several locations along the neuraxis. This chapter presents the clinical features of dysarthria resulting from stroke and its associated neurological signs. Ischemic lesions of the upper motor neuron system may be unilateral or bilateral, cortical or subcortical. Ischemic lesions in the vertebrobasilar territory can result in both upper and lower motor neuron involvement. Ataxic dysarthria is the result of lesions occurring in the territory of the superior cerebellar and posterior inferior cerebellar arteries. Dysarthria can follow ischemic lesions of the extrapyramidal system occurring in the vascular territories of the deep penetrating branches of the anterior and middle cerebral arteries.